The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy

Okamoto, Susumu; Shiga, Tohru; Yasuda, Kôichi; Watanabe, Shirô; Hirata, Kenji; Nishijima, Ken‐ichi; Magota, Keiichi; Kasai, Kazuhiko; Onimaru, Rikiya; Tuchiya, Kazuhiko; Kuge, Yuji; Shirato, Hiroki; Tamaki, Nagara

doi:10.1007/s00259-016-3431-4

Cited by 27 publications

(15 citation statements)

References 34 publications

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“…Our tumour SUVmax values appeared higher than those obtained by Havelund et al [ 44 ] who imaged rectal tumours with [ 18 F]FAZA PET at 2 h. Tumour hypoxic volumes obtained in this study were difficult to compare with those shown by Roels et al [ 42 ], who based rectal tumour ROI on [ 18 F]FDG PET. Our T:M ratio values are however similar to those obtained in other solid tumour types such as head and neck squamous cell carcinoma [ 45 – 48 ] and non-small cell lung cancer [ 49 ]. Where quoted, hypoxic tumour fraction appeared higher in these tumours than in rectal cancer [ 48 , 50 ].…”

Section: Discussionsupporting

confidence: 87%

[18F]Fluoromisonidazole PET in rectal cancer

et al. 2017

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Section: Discussionsupporting

confidence: 87%

[18F]Fluoromisonidazole PET in rectal cancer

et al. 2017

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“…Hypoxic regions in tumours are known to be more radiation-resistant than normoxic tissues and hypoxia is an independent prognostic marker for patient outcome [1–5]. Most head-and-neck cancers have hypoxic regions, which vanish in the course of radiation therapy [6]. The current gold standard to estimate hypoxic tissue is measuring the pO2 using the Eppendorf pO2 electrode [7], which not only is an invasive method but also can alter the local oxygen concentration.…”

Section: Introductionmentioning

confidence: 99%

Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

et al. 2019

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Background Hypoxia can induce radiation resistance and is an independent prognostic marker for outcome in head and neck cancer. As 18 F-FMISO (FMISO), a hypoxia tracer for PET, is far less common than 18 F-FDG (FDG) and two separate PET scans result in doubled cost and radiation exposure to the patient, we aimed to predict hypoxia from FDG PET with new techniques of voxel based analysis and texture analysis. Methods Thirty-eight patients with head-and-neck cancer underwent consecutive FDG and FMISO PET scans before any treatment. ROIs enclosing the primary cancer were compared in a voxel-by-voxel manner between FDG and FMISO PET. Tumour hypoxia was defined as the volume with a tumour-to-muscle ratio (TMR) > 1.25 in the FMISO PET and hypermetabolic volume was defined as >50% SUVmax in the FDG PET. The concordance rate was defined as percentage of voxels within the tumour which were both hypermetabolic and hypoxic. 38 different texture analysis (TA) parameters were computed based on the ROIs and correlated with presence of hypoxia. Results Within the hypoxic tumour regions, the FDG uptake was twice as high as in the non-hypoxic tumour regions (SUVmean 10.9 vs. 5.4; p<0.001). A moderate correlation between FDG and FMISO uptake was found by a voxel-by-voxel comparison (r = 0.664 p<0.001). The average concordance rate was 25% (± 22%). Entropy was the TA parameter showing the highest correlation with hypoxia (r = 0.524 p<0.001). Conclusion FDG uptake was higher in hypoxic tumour regions than in non-hypoxic regions as expected by tumour biology. A moderate correlation between FDG and FMISO PET was found by voxel-based analysis. TA yielded similar results in FDG and FMISO PET. However, it may not be possible to predict tumour hypoxia even with the help of texture analysis.

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“…It has been well documented that HDR induces reoxygenation in the hypoxic area in the poor-circulated solid tumor (Hong et al, 2016;Moon et al, 2010;Okamoto et al, 2016). The respiratory system in humans is co-developed with the cardiovascular system via crosstalk and integration of multiple cellular populations (Morrisey and Hogan, 2010).…”

Section: Improving Alveolar Gas Exchange By Hdr-induced Vasculature Mmentioning

confidence: 99%

Mitigating Coronavirus-Induced Acute Respiratory Distress Syndrome by Radiotherapy

Li¹

2020

iScience

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The acute respiratory distress syndrome (ARDS) induced by SARS-CoV-2-mediated cytokine storm (CS) in lungs leads to the high mortality in COVID-19 patients. To reduce ARDS, an ideal approach is to diminish virus loading by activating immune cells for CS prevention or to suppress the overactive cytokine-releasing immune cells for CS inhibition. Here, a potential radiation-mediated CS regulation is raised by reevaluating the radiation-mediated pneumonia control in the 1920s, with the following latent advantages of lung radiotherapy (LR) in treatment of COVID-19: (1) radiation accesses poorly circulated tissue more efficiently than blood-delivered medications; (2) low-dose radiation (LDR)mediated metabolic rewiring and immune cell activation inhibit virus loading; (3) pre-consumption of immune reserves by LDR decreases CS severity; (4) higherdose radiation (HDR) within lung-tolerable doses relieves CS by eliminating in situ overactive cytokine-releasing cells. Thus, LDR and HDR or combined with antiviral and life-supporting modalities may mitigate SARS-CoV-2 and other virus-mediated ARDS.

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The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy

Cited by 27 publications

References 34 publications

[18F]Fluoromisonidazole PET in rectal cancer

[18F]Fluoromisonidazole PET in rectal cancer

Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

Mitigating Coronavirus-Induced Acute Respiratory Distress Syndrome by Radiotherapy

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