The Renin-Angiotensin System in the Fetal Lamb

Smith, F.; Lupu, Andrei N.; Barajas, Luciano; Bauer, Robert O.; Bashore, Richard A.

doi:10.1203/00006450-197406000-00001

Cited by 58 publications

(24 citation statements)

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“…hr-1, n = 8), comparable with that reported by Smith, Lupu, Barajas, Bauer & Bashore (1974) in three acutely prepared lambs of this age. Scarisbrick (1955) in acute experiments reported low umbilical arterio-venous acetate differences.…”

Section: Psupporting

confidence: 77%

Proceedings of the Physiological Society, 8–9 November 1974, Bristol Meeting: Communications

1975

The Journal of Physiology

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Section: Psupporting

confidence: 77%

Proceedings of the Physiological Society, 8–9 November 1974, Bristol Meeting: Communications

1975

The Journal of Physiology

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“…In the adult animal, renin release from the kidney occurs through renal vascular baroreceptors, macula densa receptors and renal sympathetic nerves (1). In fetal and newborn animals, renin release can also be promoted by stimulation of renal vascular baroreceptors, and maculda densa receptors (26)(27)(28). Stimulation of neural norepinephrine release by veratridine also results in renin release in vitro from renal cortical slices of fetal and newborn sheep (4,29).…”

Section: Discussionmentioning

confidence: 99%

Role of renal sympathetic nerves in lambs during the transition from fetal to newborn life.

Smith

Smith²,

Guillery³

et al. 1991

J. Clin. Invest.

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To determine the role of renal sympathetic nerves in influencing renal function during the transition from fetal to newborn life, studies were carried out in conscious, chronically instrumented fetal sheep with either bilateral renal denervation (n = 11) or intact renal nerves (n = 12), 3-6 d after surgery. Endocrine, renal, and cardiovascular parameters were measured before and after delivery of lambs by cesarean section. Blood pressure and heart rate were similar in intact and denervated fetuses, and increased after delivery in both groups. There was also a transient diuresis and natriuresis, in the immediate postnatal period, the response being significantly greater in denervated than intact lambs (P < 0.05). By 24 h postnatally, fluid and electrolyte excretions were similar in both groups, and significantly less than fetal levels. In the absence of renal nerves, the normal rise in plasma renin activity at birth was attenuated. These data provide evidence that renal sympathetic nerves play an important role during the transition from fetal to newborn life, and support the premise that birth is associated with sympathetic activation. (J.

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“…The data on PRC in the developing rabbit differ from those observed in other species, including the rat, dog, piglet, lamb and human (2,8,14,18,21,24,25,27,28,30,33). Plasma renin concentration in the newborn rabbit was not high and was comparable to adult values.…”

Section: Discussionmentioning

confidence: 52%