The renin—angiotensin—aldosterone system and carotid artery disease in mild-to-moderate primary hypertension

Rossi, Alberto; Baldo-Enzi, Goretta; Calabrò, A.; Sacchetto, Alfredo; Pessina, Achille C.; Rossi, Gian Paolo

doi:10.1097/00004872-200018100-00007

Cited by 16 publications

(20 citation statements)

References 47 publications

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“…Aldosterone has been demonstrated to influence vascular tone and structure directly (33), even at physiological concentrations (34). This adverse role of the renin-angiotensin-aldosterone system in the vascular remodeling and in the progression of atherosclerosis has been highlighted by correlation with IMT values (35).…”

Section: Discussionmentioning

confidence: 99%

Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome

Cascella¹,

Palomba

Tauchmanovà³

et al. 2006

The Journal of Clinical Endocrinology &Amp; Metabolism

102

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Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes.Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting:A prospective baseline-controlled clinical study was conducted at the University "Federico II" of Naples School of Medicine (Naples, Italy).Patients: Fifty PCOS women age-and body mass index-matched with 50 healthy women were enrolled.Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control.Results: Aldosterone levels were significantly increased (P Ͻ 0.001) in PCOS compared with healthy women (10.5 Ϯ 3.2 vs. 5.7 Ϯ 2.5 ng/dl). In PCOS, a significant (P Ͻ 0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P Ͻ 0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion

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Section: Discussionmentioning

confidence: 99%

Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome

Cascella¹,

Palomba

Tauchmanovà³

et al. 2006

The Journal of Clinical Endocrinology &Amp; Metabolism

102

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“…Although carotid arterial morphology evaluated with the present method has been shown to be associated with the status of several pathophysiological factors (21,(32)(33)(34)(35)(36)(37)(38), measurements of carotid IMT at more points could reflect carotid atherosclerosis more accurately. This finding leaves open the possibility that MCP-1 gene polymorphism could affect more subtle atherosclerotic changes.…”

Section: Fig 2 Plasma Mcp-1 Level In Subjects Divided Into Four Gromentioning

confidence: 92%

Polymorphism of the Monocyte Chemoattractant Protein (MCP-1) Gene Is Associated with the Plasma Level of MCP-1 But Not with Carotid Intima-Media Thickness

et al. 2003

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“…13 There was an inverse relationship between plasma renin activity and carotid intima-media thickness (IMT) and severity of carotid artery lesions in patients with mild-to-moderate hypertension. 14 However, high plasma aldosterone or aldosterone-to-renin ratio (ARR) were found to be associated with impaired flow-mediated dilation and progression of subclinical atherosclerosis in young to middle-aged individuals. 15 Hence, the association between RAAS and carotid atherosclerosis and the evidence linking the RAAS with central and cerebral vascular atherosclerosis remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Plasma renin level and aldosterone to renin ratio are associated with presence of carotid plaques in patients with stable coronary artery disease

Lee

Lai

2014

J Renin Angiotensin Aldosterone Syst

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Introduction: We aimed to determine the association between plasma aldosterone and renin levels as well as their ratios with carotid plaques in patients with coronary artery disease (CAD). Materials and methods: Carotid intima-media thickness (IMT) and plaque score were evaluated in 111 patients with stable CAD. Plasma renin and aldosterone levels were measured in all patients. Aldosterone to renin ratio (ARR) was calculated. All patients were categorized into: Group 1 (normal coronary angiography), Group 2 (patients had CAD but without carotid plaque) and Group 3 (patients had CAD and at least one carotid plaque). Results: Renin levels are significantly higher in Group 3 than in Group 1 and 2. ARR was significantly lower in Group 3 than in Group 1 and 2. Renin levels were found to be positively correlated with carotid IMT and plaque score but ARR was inversely associated with carotid IMT and plaque score. Renin levels and ARR are independently associated with presence of carotid plaque in CAD patients (OR 1.124, CI 1.021–1.237, p = 0.017 and OR 0.906, CI 0.839–0.978, p = 0.011, adjusted for age, respectively). Conclusions: Plasma renin and ARR but not aldosterone are independently associated with presence of carotid plaques in CAD patients. Hence, the linkage between aldosterone and renin plays a more important role than aldosterone alone in carotid atherosclerosis.

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The renin—angiotensin—aldosterone system and carotid artery disease in mild-to-moderate primary hypertension

Cited by 16 publications

References 47 publications

Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome

Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome

Polymorphism of the Monocyte Chemoattractant Protein (MCP-1) Gene Is Associated with the Plasma Level of MCP-1 But Not with Carotid Intima-Media Thickness

Plasma renin level and aldosterone to renin ratio are associated with presence of carotid plaques in patients with stable coronary artery disease

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