The Renal Response to Acute Hypervolemia Is Caused by Atrial Natriuretic Peptides

Hirth, C.; Stasch, Johannes‐Peter; John, A.; Morich, F.; Neuser, D; Wohlfeil, Stefan

doi:10.1097/00132586-198702000-00007

Cited by 16 publications

(25 citation statements)

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“…There are several reports that suggest the role ofANP in diuresis and natriuresis after acute hypervolemia in rats (46). Recently, Hirth et al demonstrated blunted diuresis and natriuresis after volume expansion by ANP MAb (47). Our results of the attenuation of exaggerated diuresis and natriuresis in DOCA-salt rats by ANP MAb further support the role of increased plasma levels of ANP in accelerating diuresis and natriuresis in volume-overloaded state.…”

Section: Discussionsupporting

confidence: 84%

Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

Itoh¹,

Nakao²,

Mukoyama³

et al. 1989

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 84%

Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

Itoh¹,

Nakao²,

Mukoyama³

et al. 1989

J. Clin. Invest.

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“…Inasmuch as the renal response to acute blood volume expansion in the adult rat can be largely inhibited by prior injection of MAb against ANP (lo), it is likely that ANP release and the renal response to blood volume expansion are similar in the postweaning rats. It should be noted that both the present study and that of Hirth et al (10) were performed in anesthetized rats, because others have shown that rats made autoimmune to ANP have blunted diuresis and natriuresis after acute saline volume expansion when anesthetized, but not when conscious (1 1). These authors postulated that ANP may have a role in volume homeostasis only in pathophysiologic states, and that the renal response to acute volume expansion in conscious animals may be mediated by other factors (1 1).…”

Section: Discussionmentioning

confidence: 76%

Role of Atrial Natriuretic Peptide in the Response to Blood Volume Expansion in the Weanling Rat

et al. 1990

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ABSTRACT. After acute blood volume expansion (BVE) in the rat, diuresis and natriuresis are reported to be minimal in rats 20 to 30 d of age, but increase to mature levels by 40 d of age. To evaluate the role of atrial natriuretic peptide (ANP) and its renal action in BVE, anesthetized Sprague-Dawley rats were studied at 25 to 30 (group I) and 45 to 50 d of age (group 11). Hematocrit, mean arterial pressure, glomerular filtration rate, urine flow rate, urine sodium excretion, urine cyclic GMP excretion, and plasma ANP concentration ([ANP]) were measured before and after infusion of donor littermate whole blood, 2.5% body wt (BVE), and in time controls (no BVE) in each group. Baseline hematocrit, mean arterial pressure, and glomerular filtration rate were greater in group I1 than group I, but urine flow rate, urine sodium excretion, urine cyclic GMP excretion, and [ANP] did not differ. BVE caused a prompt increase in urine flow rate, urine sodium excretion, and [ANP], but not urine cyclic GMP excretion, in both groups, but there was no difference in the response between groups. Additional groups of rats of the same ages as groups I and I1 studied using a protocol similar to that of a previous report also showed the "mature" diuretic and natriuretic response even in the younger animals. We conclude that there is no further maturation of the renal response to acute BVE in the euvolemic rat after 25 d of age. The increase in [ANP] after acute BVE in the immature weanling rat is consistent with a role for ANP in mediation of the renal response. (Pediatr Res 27: 396-400, 1990) Abbreviations ANP, atrial natriuretic peptide cGMP, guanosine 3'. 5'-cyclic monophosphate FEN,, fractional excretion of sodium MAP, mean arterial pressure Compared to the adult, the immature kidney responds to acute volume expansion with attenuated diuresis and natriuresis (1-4). Since the discovery of ANP, there has been considerable interest in defining the role of ANP in volume regulation during

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“…Intravenous injection of specific antiserum (passive immunization) against AP significantly decreased urine flow and sodium excretion in response to intravenous volume expansion (18,19). These data demonstrate the role of AP as an important modulator of acute intravascular volume changes.…”

Section: Introductionmentioning

confidence: 65%

Is atriopeptin a physiological or pathophysiological substance? Studies in the autoimmune rat.

Greenwald

Sakata²,

Michener³

et al. 1988

J. Clin. Invest.

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Atriopeptin (AP), a natriuretic-diuretic and vasodilatory peptide, is synthesized and secreted from mammalian atria. The definitive role of this peptide on cardiovascular physiology and pathophysiology has yet to be determined. We developed a population of autoimmune rats sensitized against their own AP to evaluate the consequences of prolonged AP deficiency on physiological and pathophysiological processes. Natriuresis in response to acute intravenous volume expansion was inhibited in the autoimmune rat, however, natriuresis produced by chronic oral salt loading was not suppressed in these animals. Plasma AP increased threefold in the spontaneously hypertensive rat when evaluated as a function of blood pressure. Immunization of these rats had no effect on the rate of development, magnitude of their developing hypertension, or their daily sodium excretion when compared with nonimmunized controls. Mineralocorticoid escape occurred during desoxycorticosterone acetate administration to rats. The ability of rats to escape from the sodium-retaining effects of this steroid was not affected by prior immunization against AP. These results suggest that AP is an important natriuretic substance in response to acute intravascular volume loading. However, atriopeptin does not appear to be involved in the natriuretic response to chronic intravascular volume loading, blood pressure regulation, or mineralocorticoid escape.

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The Renal Response to Acute Hypervolemia Is Caused by Atrial Natriuretic Peptides

Cited by 16 publications

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Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

Role of Atrial Natriuretic Peptide in the Response to Blood Volume Expansion in the Weanling Rat

Is atriopeptin a physiological or pathophysiological substance? Studies in the autoimmune rat.

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