The Renal Excretion of Endogenous Creatinine in Man. Comparison With Exogenous Creatinine and Inulin

Creatinine clearance in renal disease. A reappraisal

“…In four patients with renal disease, however, the creatinine clearance was greater than inulin clearance (Miller and Winkler, 1938). Brod and Sirota (1948) In direct contrast with the above studies, endogenous creatinine clearance was found to differ so significantly from inulin clearance in a series of nine patients with renal disease or congestive heart failure that it could not be considered a satisfactory measure of glomerular filtration rate (Miller et al, 1952).…”

“…Creatinine clearance in man has therefore usually been found to be higher than inulin clearance, both in health (Miller and Winkler, 1938;Brod and Sirota, 1948;Hare et al, 1949;Smith, 1951 ;Mattar et al, 1952) and in disease (Miller and Winkler, 1938;Brod and Sirota, 1948;Hare et al, 1949;Smith, 1951 ; Mattar et al, Miller et al, 1952 ;Berlyne et al, 1964;Vere and Walduck, 1964 (1938) found that endogenous creatinine clearance was equal to inulin clearance in several normal subjects. In four patients with renal disease, however, the creatinine clearance was greater than inulin clearance (Miller and Winkler, 1938).…”

Prediction of creatinine clearance from serum creatinine in spinal cord injury patients

“…Careful dose adjustment, therefore, based on measurement or estimation of glomerular filtration rate (GFR) and periodic measurement of serum levels of the antibiotic are essential in reducing the risk of toxicity. In view of the need for frequent monitoring of renal function a quick and con venient means of assessing renal function is, therefore, desirable especially since the established methods of estimating GFR i. e. inulin and creatinine clearances are costly, time consuming and associated with certain other problems (Miller and Winkler, 1938;Dodge et ai., 1967).…”

Proteinuria Following Momentary Vascular Constriction

“…with distilled water, and the protein precipitated by the addition of 2 ml. each of 10 per cent sodium tungstate and 3% N sulfuric acid (15 In some cases, an approximate measurement of the glomerular filtration was attempted by determining the plasma clearance of endogenous creatinine (16). The creatinine of both plasma and urine was determined by the methods of Folin (17).…”

“…Schlombka (9) produced proteinuria in 9 of 37 subjects by immersing the lower parts of their legs in cold water for periods up to 25 minutes (average 16 minutes). He considered two possible causes; first, vascular spasm, and second, the local production in the chilled skin of some substance which affected glomerular permeability.…”