The Renal Effects of Prenatal Testosterone in Rats

Bábíčková, Janka; Borbélyová, Veronika; Tóthová, Ľubomíra; Kubišová, Katarína; Janega, Pavol; Hodosy, Július; Celec, Peter

doi:10.1016/j.juro.2014.12.093

Cited by 2 publications

(1 citation statement)

References 28 publications

(26 reference statements)

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“…Thus, sexual dimorphism in renal organogenesis as early as the third trimester in the human species could be related to testosterone secretion by male fetuses in utero [ 98 ]. Studies of prenatal exposure to testosterone have shown that the developing kidney is sensitive to testosterone [ 99 ], but its implication on renal development under physiological conditions in the fetus, as well as the molecular interaction between androgen signaling pathway and other signaling pathways implicated in nephrogenesis, remain to be further demonstrated.…”

Section: Gender Differences In Kidney Development and Organogenesismentioning

confidence: 99%

Sexual Dimorphism of Corticosteroid Signaling during Kidney Development

Laulhé

Dumeige

et al. 2021

IJMS

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Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males.

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Section: Gender Differences In Kidney Development and Organogenesismentioning

confidence: 99%

Sexual Dimorphism of Corticosteroid Signaling during Kidney Development

Laulhé

Dumeige

et al. 2021

IJMS

View full text Add to dashboard Cite

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The role of androgen and its related signals in PCOS

Xie

Song

et al. 2020

J Cellular Molecular Medi

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS‐related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.

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The Renal Effects of Prenatal Testosterone in Rats

Abstract: Prenatal testosterone induces proteinuria in adulthood. This effect is mediated via androgen receptor. Additional effects seem to be sex specific. Further studies should focus on the timing and dosing of testosterone as well as the applicability to human development.

Cited by 2 publications

References 28 publications

Sexual Dimorphism of Corticosteroid Signaling during Kidney Development

Sexual Dimorphism of Corticosteroid Signaling during Kidney Development

The role of androgen and its related signals in PCOS

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