The Renal Clearance of Endogenous Estrogens in Late Pregnancy*

Brown, Corrine; Saffan, Benjamin D.; Howard, Carolyn M.; Preedy, J. R. K.

doi:10.1172/jci104914

Cited by 43 publications

(4 citation statements)

References 17 publications

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“…It is thus not surprising that determinations of the maternal urinary excretion of oestriol or total oestrogens have long been used in attempts to assess the fetoplacental function in abnormal pregnancies. Changes in the renal clearance of oestrogens may, however, occur during these pregnancies (6,7) and in addition the sampling and handling of urine involves a number of practical problems. Many of these would be alleviated if the determination in urine could be replaced by rapid and reliable methods for the assay of oestrogens in plasma.…”

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Nonconjugated Oestrone, Oestradiol‐17β and Oestriol During Uncomplicated Pregnancy

Lindberg

Johansson

Nilsson

1974

Acta Obstet Gynecol Scand

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Plasma levels of unconjugated oestrone,' oestradiol-17p and oestriol from the 22nd week of uncomplicated human pregnancy until delivery have been estimated by means of radioimmunoassays. In some cases, the oestrogens were separated by Sephadex LH-20 chromatography before the radioimmunoassays. Plasma levels of unconjugated oestrone increased from a mean of 3 ng/ml in the 22nd week to 9.9 ng/ml in week 41. Oestradiol-17p concentrations in plasma were estimated by two different radioimmunoassays. With the most specific method, plasma mean concentrations were found to rise from 7.5 ng/ml in the 22nd week to 23.6 ng/ml in the 38th week. A somewhat less specific assay with a crossreaction of 50 per cent for oestrone gave a mean level of 8.3 ng/ml in week 22 increasing to 26.2 ng/ml in week 41. When unconjugated oestradiol-17p in plasma was estimated after Sephadex LH-20 chromatography somewhat lower concentrations were found. ' The following abbreviations and trivial names are used: oestrone = 3-hydroxy-1,3,5( 10)-oestratrien-1 7-one; oestradiol-17P = 1,3,5( IO)-oestratriene-3,17P-diol; oestriol = 1,3,5( lO)-oestratriene-3,16a, 17P-triol; dehydroepiandrosterone = DHA = 3P-hydroxy-5-androsten-17-one; dehydroepiandrosterone sulphate = DHAS = 3P-sulphoxy-Sandrosten-1 7-one; 16a-hydroxydehydroepiandrosterone = 16a-OH-DHS = 30, 16a-dihydroxy-5-androsten-17-one.The results for the estimation of unconjugated oestriol in plasma were similar whether or not the sample was separated by Sephadex LH-20 chromatography. The mean level of 2.9 ng/ml in week 22 increased to 14.3 ng/ml in week 41. The range of all the studied oestrogens increased towards term. The quotients (oestrone + oestradiol-17p)/oestriol, and oestradiol-17p/oestriol decreased towards the end of pregnancy.Individual patients tested regularly during the latter part of pregnancy showed a characteristic pattern for all three oestrogens with rather small deviations from the original relative level within the normal range, but with large fluctuations towards the end of pregnancy.Significant variations in the plasma levels of unconjugated oestradiol-17p and oestriol were noted during a 24-hour period and during shorter periods. However, no systematic circadian rhythm was found.

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Section: Introductionmentioning

confidence: 99%

Plasma Levels of Nonconjugated Oestrone, Oestradiol‐17β and Oestriol During Uncomplicated Pregnancy

Lindberg

Johansson

Nilsson

1974

Acta Obstet Gynecol Scand

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“…Σημειωτέον, ότι κυρίως ύπόλογον τής αυξήσεως τής TBG καί τοΰ ΡΒΙ εϊναι το κλάσμα τής οιστραδιόλης ή τα παράγωγα ταύτης 148 . Το γεγονός αυτό πιθανώς οφείλε ται εις τήν μεγαλυτέραν νεφρικήν κάθαρσιν τής οίστριόλης, ώς προς τήν τοιαύτην τής οίστραδιόλης 31 .…”

Section: "öSijunclassified

“…Αί στάθμαι τοϋ PB Ι τής TBG καί τής ελευθέρας θυροξίνης παρα μένουν κατ' άλλους μεν σταθερώς αμετάβλητοι, μετά τήν κατά το ποώτον τρίμηνον άρχικήν αϋξησιν 254 , 204 , 284 , κατ' άλλους δε τόσον ή ολική, όσον καί ή ελευθέρα θυροξίνη εμφανίζουν πτώσιν 31 . Oi η μέτεροι Κούτρας καί συν.…”

Section: κινητική τοΰ μεταβολισμού τής θυροξίνης έπί κυήσεως ιunclassified

“…Ή ύπο τών Man καί Bondy 173 , προταθείσα το 1957 μέθοδος με τρήσεως τοΰ BEI δίδει πλέον αξιόλογα αποτελέσματα, δεδομένου δτι μόνον ai θυρεοειδικαί όρμόναι έκχυλίζονται δια βουτανάλης, ουχί δμως καί το ελεύθερον ίώδιον. Ούχ ήττον δμως καί ή μέθοδος αυτή δύναται να έπηρεασθη παρουσία μεγάλης ποσότητος εξωγενούς ιωδίου εις το πλάσμα, άλλ' ,είς μικρότερον ασφαλώς βαθμον τοΰ ΡΒΙ 31 .…”

Section: συζητησις α' μεθοδολογιαunclassified

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