The Renal Changes in Rabbits Inoculated with Streptococci

LeCOUNT, E. R.; Jackson, Leila

doi:10.1093/infdis/15.2.389

Cited by 14 publications

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“…In 2 kidneys no fat can be demonstrated microscopically. Seven kidneys show chronic interstitial nephritis, and 4 show loci of lymphoid and plasma cells in the interstitial tissues, these changes being combined in two cases (15). Sixteen animals were examined for albuminuria before being used as controls and also after they had been in the open cage or in the chamber with practically normal oxygen content at the Nutrition Laboratory, and 5 of these on later examination showed albuminuria.…”

Section: Kidneysmentioning

confidence: 99%

The Pathological Effects of Atmospheres Rich in Oxygen

Karsner

1916

Journal of Experimental Medicine

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In spite of numerous abnormalities or non-experimental lesions in the rabbit certain facts can be considered as established. It has been known for many years that pneumonia is produced by the more or less prolonged inhalation of high partial pressures of oxygen. The studies herein reported show that atmospheres containing 80 to 96 per cent oxygen under normal barometric pressure produce in 24 hours, or more commonly 48 hours, congestion, edema, epithelial degeneration and desquamation, fibrin formation, and finally a pneumonia, probably of irritative origin and to be described as a fibrinous bronchopneumonia. The important new points are the time relations of these changes and definition of the type of the pneumonia. Other studies have noted slight passive congestion, but it is now established that this is to be accounted for in most cases by dilatation of the right side or of both sides of the heart. This congestion affects all the abdominal viscera and is accompanied by certain secondary changes such as cloudy swelling of the parenchymatous organs and phagocytosis of erythrocytes by endothelial cells of the mesenteric lymph nodes. Although deficiency of oxygen may affect the hematopoietic system, the animals subjected to high oxygen percentages failed to show any demonstrable pathologic changes in blood, spleen, lymph nodes, or bone marrow, except for the presence of congestion. This study is the first of a comprehensive series projected in and under the direction of the Carnegie Nutrition Laboratory. Different animals and various methods of attack will be employed in the investigation.

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Section: Kidneysmentioning

confidence: 99%

The Pathological Effects of Atmospheres Rich in Oxygen

Karsner

1916

Journal of Experimental Medicine

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“…Ophiils (6) described occasional glomerular lesions after the intravenous injection of rabbits with 512 ACUTE GLO~fERULITIS streptococci; while Bell, Clawson and Hartzell (7) have noted scattered glomerular lesions in monkeys after the repeated injection of both hemolytic and non-hemolytic streptococci. Indefinite or entirely negative results have been obtained by LeCotmt and Jackson (8), by Faber and Murray (9), by Major (10) and by Leiter, all of whom injected streptococci intravenously. Leiter also employed intracardiac injections, to avoid the pulmonary filter, with negative results.…”

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confidence: 94%

Experimental Acute Glomerulitis

Lukens

Longcope

1931

Journal of Experimental Medicine

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1. Both focal and diffuse glomerulitis has been produced in rabbits by the injection directly into the left renal artery of suspensions of heat killed hemolytic streptococci. 2. Similar lesions in the glomeruli could not be obtained by the injection of suspensions of bismuth oxychloride into the left renal artery of normal rabbits. 3. The acute glomerulitis occurred in only about one-half of the rabbits employed for the experiments. 4. Glomerulitis was observed much more frequently in rabbits in which an acute localized streptococcus infection had been produced by the intracutaneous injection of living hemolytic streptococci, than in normal rabbits. The occurrence of acute glomerulitis was usually associated with a well marked skin reaction to the filtrates of hemolytic streptococci.

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“…35,36 One of LeCount's research papers, ''Fat replacement of the glycogen in the liver as a cause of death,'' 37 which first described an association of hepatic steatosis and sudden death in alcoholics, appeared in the very first issue of Archives of Pathology in 1926, and it was considered relevant enough in 2001 for Gregorio Chejfec, MD, to write a paper elaborating on the advances in this subject during the past 75 years. 38 Other significant papers that he published reflecting his diverse interests were on the pathology of Rocky Mountain spotted fever 39 as well as basic research in infectious disease 40 and in biochemistry 41 (on rabbits 40 and on rats, 41 respectively) and on the amino acid content of the keratin in goose feathers. 42 LeCount was a respected forensic pathologist as well, and was physician to the coroner's office of Cook County from 1911 to 1924.…”

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confidence: 99%

Report of a Case With Clinical and Pathologic Features of Castleman Disease That Predates Castleman's Report by More Than 50 Years

Pai

Naresh

Borges

2022

Archives of Pathology &Amp; Laboratory Medicine

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Context.— In 1954, Benjamin Castleman, MD, described what was then believed to be a new entity in lymph node pathology. Initially labeled “Hyperplasia of the mediastinal node” and then “Localized mediastinal lymph node hyperplasia resembling thymoma,” we now recognize the condition with the eponym “Castleman disease.” We document a paper that describes the same condition, a half century before Castleman did. Objective.— To report the striking resemblance between Castleman disease and the lymph node reported in the paper published by Edwin R. LeCount, MD, titled “Lymphoma, a benign tumor representing a lymph gland in structure,” published in Journal of Experimental Medicine in 1899. We also provide an overview of the remarkable achievements of LeCount. Design.— We compared the elucidation in the original paper by LeCount with the morphologic details in the papers published by Castleman et al. Material on the life of LeCount was compiled from the scientific literature, the Internet, and the files of the University of Chicago. Results.— LeCount's description and illustrations of the lymph node are uncannily similar to the onion-skinning and vascularity that Castleman documented. Conclusions.— LeCount deserves credit for his depiction of a hitherto-unreported entity.

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The Renal Changes in Rabbits Inoculated with Streptococci

Abstract: A number of writers have commented on the difficulties in producing chronic nephritis in animals.

Cited by 14 publications

References 0 publications

The Pathological Effects of Atmospheres Rich in Oxygen

The Pathological Effects of Atmospheres Rich in Oxygen

Experimental Acute Glomerulitis

Report of a Case With Clinical and Pathologic Features of Castleman Disease That Predates Castleman's Report by More Than 50 Years

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