The Renaissance of Male Infertility Management in the Golden Age of Andrology

Calogero, Aldo E.; Cannarella, Rossella; Agarwal, Ashok; Hamoda, Taha Abo-Almagd Abdel-Meguid; Rambhatla, Amarnath; Saleh, Ramadan; Boitrelle, Florence; Ziouziou, Imad; Toprak, Tuncay; Gül, Murat; Avidor‐Reiss, Tomer; Kavoussi, Parviz K.; Chung, Eric; Birowo, Ponco; Ghayda, Ramy Abou; Ko, Edmund; Colpi, Giovanni M.; Dimitriadis, Fotios; Russo, Giorgio Ivan; Martínez, Marlon; Çalık, Gökhan; Kandil, Hussein; Salvio, Gianmaria; Mostafa, Taymour; Lin, Haocheng; Park, Hyun Jun; Gherabi, Nazim; Phuoc, Nguyen Ho Vinh; Nguyen, Quang; Adriansjah, Ricky; Vignera, Sandro La; Micić, S.; Durairajanayagam, Damayanthi; Şerefoğlu, Ege Can; Karthikeyan, Vilvapathy Senguttuvan; Kothari, Priyank; Atmoko, Widi; Shah, Rupin

doi:10.5534/wjmh.220213

Cited by 20 publications

(25 citation statements)

References 163 publications

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“…Table 2 [ 3 22 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 ] illustrates that 23 articles were published in prestigious peer-reviewed journals by author contributions representing 46 countries. Broadly classified, these articles tackled contemporary challenges in andrology spanning across topics of sperm DNA damage, semen analysis, laboratory issues in relation to assisted reproductive technique (ART), sperm recovery, etc.…”

Section: Resultsmentioning

confidence: 99%

“…Andrology is a melting pot of multiple medical specialties and disciplines that share the common focus of male reproductive and sexual health from adolescence to adulthood [ 1 ]. In many regions of the world, andrology has developed substantially and come to its golden age [ 2 3 ]. Compared to other medical disciplines, the growth of the andrological specialty came later, allowing it to capitalize on modern technological advancements spanning basic, clinical, and translational sciences [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

Ansari

Savira

Atmoko

et al. 2024

World J Mens Health

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Purpose There are no published examples of a global online research collaborative in andrology. We describe the development, profile and member characteristics of the first consortium of this type, the Global Andrology Forum (GAF). Materials and Methods An online survey sent to all GAF members collected demographic information (sex, age, experience, academic title, degrees, country, specialty, profession). It also tapped data on members’ characteristics e.g., skills in research, software and statistics; preferred activities; time commitments; expected roles; and interest in participating in research, in GAF’s scientific activities and collaborative online research. The findings were analyzed and tabulated. We outline members’ demographic and professional characteristics and scientific achievements to date. A narrative approach outlined GAF’s structure and functioning. Results A total of 418 out of 540 members completed the survey and were included in the analysis (77.4% response rate). The sample comprised mainly urologists (34.2%) and a third of the respondents had practiced for >15 years (33.3%). Up to 86.1% of the members expressed interest in being actively engaged in writing scientific articles. A third of the sample (37.1%) could dedicate 4 to 6 hours/week. Few respondents reported skills in statistics and artwork (2.6% and 1.9% respectively). Members were assigned to specific roles based on their expertise and experiences. Collaborative working ensured the timely completion of projects while maintaining quality. For outcomes, GAF published 29 original articles within one year of its creation, with authors from 48 countries spanning topics that included varicocele, sperm DNA damage, oxidative stress, semen analysis and male infertility, oocyte/embryo, and laboratory issues of assisted reproductive technique (ART) and male infertility evaluation. Conclusions GAF is a successful global online andrology research model. A healthy number of scientific articles have been published. Given such effectiveness, adopting the GAF model could be useful for other disciplines that wish to create and coordinate successful international online research groups.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

Ansari

Savira

Atmoko

et al. 2024

World J Mens Health

Self Cite

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“…Furthermore, the rapid growth of research in the last twenty years is probably attributable to the improvement of diagnostic imaging techniques and, in particular, of multiparametric magnetic resonance (mpRMI), which has allowed an adequate study of the disease, improving its staging, allowing targeted biopsies and the adequate active surveillance of the less aggressive forms [11]. Furthermore, in the last few years, a new thrust of research can probably be attributed to the extensive use of artificial intelligence applied to the study of mpRMI images [7].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, andrology is experiencing a "renaissance", with a growing interest in the genetic and epigenetic aspects of infertility and other andrological diseases. Furthermore, the use of artificial intelligence methods to study neoplastic diseases, such as prostate and testicular tumors, is another example of how andrological research has evolved in recent years [7]. Born as a branch of endocrinology or urology, today, andrology represents a fully developed discipline, which is destined to grow further.…”

Section: Introductionmentioning

confidence: 99%

Productivity Index in Clinical Andrology: Research Directions on High-Impact Topics and in Particular on Male Infertility

Crafa

Calogero

Cannarella

et al. 2023

JCM

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Purpose: Andrological diseases have an important social and economic impact as they cause a serious impairment of the quality of life of the affected patient. Epidemiologically, the impact of these disorders is progressively increasing, as demonstrated by the ever-growing prevalence of male infertility. This evidence justifies the rapid development of research in andrology that the scientific community has undertaken in recent decades. This study aims to evaluate the productivity index of the main andrological topics studied and reported in the literature. Methods: The total number of published articles was extracted from the Scopus database by entering the following keywords and mesh terms: “Male Infertility”, “Erectile Dysfunction”, “Premature Ejaculation”, “Male Hypogonadism”, “Testicular Tumors”, “Prostate Cancer”, “Prostatic hyperplasia”, “Prostate hyperplasia”, “Prostatitis”, “Prostate inflammation”, and “Male Accessory Gland Infections”. Furthermore, a list of the top 50 researchers sorted by productivity was created for each topic. For male infertility, a further search was performed by combining the search term “male infertility” with the above-mentioned terms. Thus, a list of the top 30 authors in order of productivity was also extracted. The graphs were created using Excel. Results and Conclusions: As could be expected, we observed that prostate cancer and male infertility were the two most investigated topics, followed by benign prostatic hyperplasia and erectile dysfunction, whose prevalence is set to increase given the progressive aging of the population. Less investigated is the inflammation of the accessory sexual glands. In conclusion, this study provides a ranking of the main andrological topics investigated in the literature, also presenting the top list of the most productive authors for each one.

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“…Although conventional semen analysis is the cornerstone of male fertility evaluation, it is limited in its ability to capture the functional and molecular aspects of spermatozoa, such as fertilization potential and DNA or chromosomal integrity [ 1 , 2 ]. Over the past few decades, sperm DNA fragmentation (SDF) and its diagnostic utility for male infertility have captured the interest of many reproductive scientists and clinicians worldwide [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Sperm DNA fragmentation in male infertility: From bench to bedside

Farkouh,

Saleh,

Shah

et al. 2023

Arab Journal of Urology

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Objectives Sperm DNA fragmentation (SDF) is a molecular marker of sperm chromatin health. Elevated SDF is associated with male infertility, recurrent pregnancy loss, and failure of assisted reproductive technologies (ART). In 2021, the sixth edition of the World Health Organization (WHO) Manual for the Laboratory Examination and Processing of Human Semen has listed SDF as an extended test of semen that can be ordered under certain circumstances. However, the manual neither explained the indications for testing nor provided clear guidance on diagnostic thresholds. Methods This article summarizes the current body of knowledge regarding clinical applications of SDF, including the appropriate population to test, methods of testing, and management strategies. Results Several etiologic factors and pathophysiologic mechanisms for SDF have been described including poor lifestyle habits, noxious exposures, and varicocele. Four SDF assays are included in the WHO manual and may be utilized based on resources and expertise. Strategies to lower SDF levels in infertile men include addressing underlying causes, supplementation with antioxidants, shorter abstinence periods, and use of testicular sperm for intracytoplasmic sperm injection. Conclusion SDF testing can be implemented in the evaluation of infertile men and couples experiencing ART failure and appropriate management strategies can be offered to improve reproductive outcomes. There is vast potential for future research regarding the clinical utility of SDF in the evaluation and treatment of infertile couples.

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The Renaissance of Male Infertility Management in the Golden Age of Andrology

Cited by 20 publications

References 163 publications

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

Productivity Index in Clinical Andrology: Research Directions on High-Impact Topics and in Particular on Male Infertility

Sperm DNA fragmentation in male infertility: From bench to bedside

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