The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters

Kasprzyk-Hordern, Barbara; Dinsdale, Richard M.; Guwy, Alan J.

doi:10.1016/j.watres.2008.10.047

Cited by 1,428 publications

(575 citation statements)

References 41 publications

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“…Most commonly used parabens, MeP, PrP, EtP, and BuP, were efficiently removed (97.6-99.8%) during this progress, while PHBA showed moderate removal efficiency of 78.6%. Similar results were also found in other WWTPs from the United Kingdom [41], Spain [11], and Denmark [42], with a very high removal efficiency exceeding 90%. It is reported that the persistence of parabens seems to slightly increase with the length of the alkyl chain [11].…”

Section: Analytessupporting

confidence: 87%

Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant

Shi

Gao

et al. 2015

Journal of Hazardous Materials

144

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Section: Analytessupporting

confidence: 87%

Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant

Shi

Gao

et al. 2015

Journal of Hazardous Materials

144

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“…As expected, concentrations in EWW were usually higher than in SW. In agreement with other studies [10] and [31], preservatives were found at very low levels. This was also observed for benzophenone-1, benzophene-2 and benzophenone-3, whilst benzophenone-4 was one of the compounds found at higher concentrations.…”

Section: Sw (N = 11) Eww (N = 11)supporting

confidence: 93%

“…Regarding PCPs, in other works highest concentrations were found for methylparaben and benzophenone-4 [10,31], which is in accordance with the present study. The presence of pharmaceuticals in "Albufera de Valencia" lake has been previously reported in literature [32], …”

supporting

confidence: 93%

“…For instance, in a study carried out by Kasprzyk-Hordern et al [31], the pharmaceuticals ibuprofen, diclofenac, gabapentin, furosemide and valsartan were also frequently found in SW samples from United Kingdom and their concentration levels were similar to those found in our study. Regarding PCPs, in other works highest concentrations were found for methylparaben and benzophenone-4 [10,31], which is in accordance with the present study.…”

supporting

confidence: 91%

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Multi-class determination of personal care products and pharmaceuticals in environmental and wastewater samples by ultra-high performance liquid-chromatography-tandem mass spectrometry

Gracia-Lor

Martínez

Sancho

et al. 2012

Talanta

110

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In this work, a multi-class method for the simultaneous determination of 17 emerging contaminants, including pharmaceuticals and personal care products, has been developed.Target analytes were two anti-inflammatories, a lipid regulator agent, two angiotensin II antagonists, two antiepileptic drugs and a diuretic. Among personal care products, four preservatives and five UV filters were included. The method is based on solid-phase extraction (SPE) using Oasis HLB cartridges followed by ultra-high performance liquid chromatographytandem mass spectrometry (UHPLC-MS/MS). Up to three simultaneous transitions per compound were acquired to assure a reliable identification. A detailed study of the extraction process efficiency and matrix effects was carried out in surface water and effluent wastewater.The use of isotope-labeled internal standards (ILIS) was tested to compensate both potential SPE losses during sample extraction and signal suppression/enhancement observed, especially in EWW. Satisfactory correction in all water samples was only ensured when the own analyte ILIS was used. The use of analogues ILIS was a rather useful approach for correction in the majority of the samples tested when analyte ILIS was unavailable. The method was successfully validated in five different surface water (SW) samples and five effluent wastewater (EWW) samples spiked at two concentration levels (0.05 and 0.5 μg/L in SW; 0.1 and 0.5 μg/L in EWW). The developed method was applied to the analysis of 22 samples (SW and EWW) from the Spanish Mediterranean area and 51 reservoir water samples from Colombia. Personal care products were frequently detected, with the highest concentrations corresponding to benzophenone and benzophenone-4 (samples from Spain), and methylparaben (samples from Colombia). Several pharmaceuticals were detected in the Spanish samples, where irbesartan 3 and valsartan -two Angiotensin II antagonists that are not commonly monitored in the aquatic environment -were the compounds most frequently detected.

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“…In addition to conventional pollutants, however, thousands of pharmaceuticals are excreted by humans in intact and metabolized forms, reaching WWTPs before being released into the environment (Kolpin et al ., 2002). The ability of the microbes in WWTPs to biotransform these chemicals is an area of great interest (Carballa et al ., 2004; Castiglioni et al ., 2005; Nakada et al ., 2006; Kasprzyk‐Hordern et al ., 2009). Substantial research has advanced our knowledge of pharmaceutical biotransformation pathways (Ellis et al ., 2006) and the transformation products formed during treatment (Kern et al ., 2010).…”

Section: Introductionmentioning

confidence: 99%

Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment

Stadler

Vela

Jain

et al. 2017

Microbial Biotechnology

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SummaryIn addition to removing organics and other nutrients, the microorganisms in wastewater treatment plants (WWTPs) biotransform many pharmaceuticals present in wastewater. The objective of this study was to examine the relationship between pharmaceutical biotransformation and biodiversity in WWTP bioreactor microbial communities and identify taxa and functional genes that were strongly associated with biotransformation. Dilution‐to‐extinction of an activated sludge microbial community was performed to establish cultures with a gradient of microbial biodiversity. Batch experiments were performed using the dilution cultures to determine biotransformation extents of several environmentally relevant pharmaceuticals. With this approach, because the communities were all established from the same original community, and using sequencing of the 16S rRNA and metatranscriptome, we identified candidate taxa and genes whose activity and transcript abundances associated with the extent of individual pharmaceutical biotransformation and were lost across the biodiversity gradient. Metabolic genes such as dehydrogenases, amidases and monooxygenases were significantly associated with pharmaceutical biotransformation, and five genera were identified whose activity significantly associated with pharmaceutical biotransformation. Understanding how biotransformation relates to biodiversity will inform the design of biological WWTPs for enhanced removal of chemicals that negatively impact environmental health.

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The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters

Cited by 1,428 publications

References 41 publications

Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant

Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant

Multi-class determination of personal care products and pharmaceuticals in environmental and wastewater samples by ultra-high performance liquid-chromatography-tandem mass spectrometry

Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment

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