The Reliability of Puff Topography and Subjective Responses During Ad lib Smoking of a Single Cigarette

Perkins, Kenneth A.; Karelitz, Joshua L.; Giedgowd, Grace E.; Conklin, Cynthia A.

doi:10.1093/ntr/ntr150

Cited by 64 publications

(76 citation statements)

References 17 publications

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“…The University of Wisconsin Center for Tobacco Research and Intervention smoking cessation trials include only subjects who actively sought treatment for smoking cessation (22)(23)(24). Treatment seeking is associated with high levels of tobacco dependence (50), higher number of cigarettes smoked, and perhaps higher smoking intensity as well (51). The unique features of this sample may have influenced the genetic associations observed.…”

Section: Original Researchmentioning

confidence: 99%

Beyond Cigarettes Per Day. A Genome-Wide Association Study of the Biomarker Carbon Monoxide

Bloom¹,

Hartz²,

Baker

et al. 2014

Annals ATS

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Rationale: The CHRNA5-CHRNA3-CHRNB4 locus is associated with self-reported smoking behavior and also harbors the strongest genetic associations with chronic obstructive pulmonary disease (COPD) and lung cancer. Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking.Objectives: To compare the genetic associations of exhaled carbon monoxide (CO), a biomarker of current cigarette exposure, with self-reported smoking behaviors.Methods: A total of 1,521 European American and 247 African American current smokers recruited into smoking cessation studies were assessed for CO at intake before smoking cessation. DNA samples were genotyped using the Illumina Omni2.5 microarray. Genetic associations with CO and smoking behaviors (cigarettes smoked per day, Fagerstrom test for nicotine dependence) were studied. Measurements and Main Results:Variants in the CHRNA5-CHRNA3-CHRNB4 locus, including rs16969968, a nonsynonymous variant in CHRNA5, are genomewide association study-significantly associated with CO (b = 2.66; 95% confidence interval [CI], 1.74-3.58; P = 1.65 3 10 28 ), and this association remains strong after adjusting for smoking behavior (b = 2.18; 95% CI, 1.32-3.04; P = 7.47 3 10 27 ). The correlation between CO and cigarettes per day is statistically significantly lower (z = 3.43; P = 6.07 3 10 24 ) in African Americans (r = 0.14; 95% CI, 0.02-0.26; P = 0.003) than in European-Americans (r = 0.36; 95% CI, 0.31-0.40; P = 0.0001).Conclusions: Exhaled CO, a biomarker that is simple to measure, captures aspects of cigarette smoke exposure in current smokers beyond the number of cigarettes smoked per day. Behavioral measures of smoking are therefore insufficient indices of cigarette smoke exposure, suggesting that genetic associations with COPD or lung cancer that persist after adjusting for self-reported smoking behavior may still reflect genetic effects on smoking exposure.

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Section: Original Researchmentioning

confidence: 99%

Beyond Cigarettes Per Day. A Genome-Wide Association Study of the Biomarker Carbon Monoxide

Bloom¹,

Hartz²,

Baker

et al. 2014

Annals ATS

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“…Immediately after participants extinguished the cigarette, they completed post-cigarette assessments identical to the pre-cigarette assessments except for the inclusion of an additional Cigarette Evaluation Questionnaire (CEQ; see Experimental Session Measures section). As previously reported, subjective measures during the ad lib smoking of a single cigarette following normal smoking have high reliability (Perkins et al, 2012).…”

Section: Cigarette Administration Proceduresmentioning

confidence: 69%

“…This paradigm is useful for identifying stable individual differences in smoking reinforcement and reward that may serve to maintain smoking behavior under typical conditions (Perkins, Karelitz, Giedgowd, & Conklin, 2012). Given prior empirical reports and theory indicating that AS is associated with greater interoceptive abilities (Evatt & Kassel, 2010;Leyro, Zvolensky, Vujanovic, & Bernstein, 2008;Perkins et al, 2010), we hypothesized that AS would predict greater negative affect reduction, positive affect enhancement, and psychological reward from smoking after statistically controlling for covariance with anxiety symptoms.…”

Section: Introductionmentioning

confidence: 99%

Anxiety Sensitivity as a Predictor of Acute Subjective Effects of Smoking

Wong

Krajisnik

Truong

et al. 2012

Nicotine & Tobacco Research

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introduction: Anxiety sensitivity (i.e., AS; the degree to which one believes that anxiety and its related sensations are harmful) is a stable trait that is associated with habitual smoking. Yet, the mechanisms linking AS and smoking are unclear. A promising hypothesis is that high-AS individuals are more sensitive to the acute subjective reinforcing effects of smoking and are, therefore, more prone to tobacco dependence. This study examined trait AS as a predictor of several subjective effects of cigarette smoking.

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“…A cigarette is inserted into one side of the device and the user puffs from the opposite side of the device. With widespread reported use in the literature, it is surprising that there have only been four published studies designed to assess reliability and validity of cigarette puff data collected with the CReSSmicro™ and bench-top devices (29)(30)(31)(32). LEE et al (29) conducted two small clinical trials with the first comparing puff volume, puff duration, inter-puff interval and maximum puff velocity as measured by a CReSS device (portable or bench-top device not specified) on four different days in seven smokers.…”

Section: Introductionmentioning

confidence: 99%

“…Using a three-factor within-subject analysis of variance (measurement method × cigarette type × cigarette number) and Tukey's honestly significant difference (p < 0.05) methods both the CReSS bench-top and portable devices were found to be reliable with two caveats: 1) compared to video recording both the bench-top and CReSSmicro™ devices measured statistically significantly shorter puff durations and; 2) the benchtop CReSS device measured statistically significantly larger average and total puff volumes than the CReSSmicro™ device. More recently, PERKINS et al (32) compared puff number, total puff volume and maximum puff volume measured using a CReSS device (portable or bench-top device not specified) in 94 smokers over four sessions. Using ICC, excellent reliability (ICC > 0.86) was reported for each measured parameter.…”

Section: Introductionmentioning

confidence: 99%

Laboratory Evaluation of the CReSSmicro™ Portable Topography Device: Implications for Clinical Research

Oldham¹,

Plunkett²,

Fisher³

et al. 2014

Contributions to Tobacco Research

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SUMMARYPerformance of the CReSSmicro™ v.2.0.0 portable smoking topography device was evaluated in a controlled laboratory environment using a calibrated smoking machine to generate known, reproducible smoking topographies. Device performance was evaluated using unlit and lit cigarettes over a range of puff volumes (25 to 100 mL) at 2 s puff duration using a sine wave profile. The device missed 93% and 100% of the 25 mL/2 s puffs for unlit and lit cigarettes, respectively. The device underreported puff durations for the entire volume range, i.e., from 40 mL (0.9 ± 0.17 s) to 100 mL (1.6 ± 0.11 s) for both unlit and lit cigarettes. Puff volumes were under reported for lower volumes from 40 mL (25.6 ± 5.5 mL) to 70 mL (68.8 ± 3.7 mL) for both unlit and lit cigarettes and slightly over reported for higher volumes from 85 mL (89.4 ± 7.6 mL) to 100 mL (103.4 ± 9.8 mL) for lit cigarettes. Experimental results indicated that a 12.5-20mL/s (750-1,200 mL/min) flow threshold for puff recognition was responsible for the observed results. This study reinforces the importance of fully understanding device performance prior to performing clinical studies of human smoking topography. [Beitr. Tabakforsch. Int. 26 (2014) Zigaretten wurden jeweils 93 % bzw. 100 % der 25 mL/2 sZüge vom Gerät nicht gezählt. Das Gerät wies in allen gewählten Volumina, d.h. von 40 mL (0,9 ± 0,17 s) bis 100 mL (1,6 ± 0,11 s), für sowohl nicht angezündete als auch angezündete Zigaretten eine zu geringe Zugdauer aus. Die Zugvolumina wurden bei den niedrigeren Volumina von 40 mL (25,6 ± 5,5 mL) bis 70 mL (68,8 ± 3,7 mL) für sowohl nicht angezündete als auch angezündete Zigaretten geringer als tatsächlich angegeben und bei den höheren Volumina von 85 mL (89,4 ± 7,6 mL) bis 100 mL (103,4 ± 9,8 mL) für angezündete Zigaretten etwas zu hoch angegeben. Die Versuchsergebnisse zeigten, dass ein Durchflussschwellenwert von 12,5-20 mL/s (750-1.200 mL/min) bei der Bestimmung der Züge für die beobachteten Ergebnisse verantwortlich war. Diese Studie unterstreicht, wie wichtig es ist, die Leistungsfähigkeit der Maschinen genau zu kennen, bevor klinische Studien zur Rauchtopographie beim Menschen durchgeführt werden können. [Beitr. Tabakforsch. Int. 26 (2014)

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The Reliability of Puff Topography and Subjective Responses During Ad lib Smoking of a Single Cigarette

Abstract: Puff topography and subjective measures during the ad lib smoking of a single cigarette are highly reliable. Smoking responses during a single ad lib smoking session may be useful in identifying stable individual differences in smoking reinforcement and reward.

Cited by 64 publications

References 17 publications

Beyond Cigarettes Per Day. A Genome-Wide Association Study of the Biomarker Carbon Monoxide

Beyond Cigarettes Per Day. A Genome-Wide Association Study of the Biomarker Carbon Monoxide

Anxiety Sensitivity as a Predictor of Acute Subjective Effects of Smoking

Laboratory Evaluation of the CReSSmicro™ Portable Topography Device: Implications for Clinical Research

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