Breast cancer is known as one of the most common cancers among women, Breast cancer accounts for 22.9% of all cancers in women, and in 2016, approximately 3.5 million women were living with a history of breast cancer in the United States (Bertucci et al., 2012; Marriotto et al., 2017). According to the latest statistics of the Iranian Cancer Research Center, about 8,500 new cases of breast cancer are reported every year, of which 1,400 deaths are caused by breast cancer. Also, currently about 40,000 people in the country are suffering from this disease (Tahergorabi et al., 2014).Over the years, many genes and proteins have been discovered that play different roles in carcinogenesis of breast cancer (Khan et al., 2019). One of the most commonly mutated human carcinogens are RAS proteins which remain a critical target for novel treatments (Marin-Ramos et al., 2019). Members of the RAS family are low molecular weight monomeric GTP-binding