The relevance of minor histocompatibility antigens in solid organ transplantation

Dierselhuis, Miranda P.; Goulmy, Els

doi:10.1097/mot.0b013e32832d399c

Cited by 72 publications

(47 citation statements)

References 70 publications

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“…8 Moreover, the role of H-Y Ags in graft rejection of solid organ transplantations has also been reported extensively, particularly in kidney transplantations. 33,34 In our study, female recipients with Sex incompatibility in CBT T Konuma et al male donors were significantly associated with a lower incidence of platelet engraftment, but not neutrophil engraftment. Our data showed that the most important factor in neutrophil and platelet engraftment was the cord blood CD34 þ cell count, indicating that this is more important than sex incompatibility in engraftment after CBT.…”

Section: Discussionmentioning

confidence: 74%

Impact of sex incompatibility on the outcome of single-unit cord blood transplantation for adult patients with hematological malignancies

Konuma

Kato

Ooi

et al. 2014

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 74%

Impact of sex incompatibility on the outcome of single-unit cord blood transplantation for adult patients with hematological malignancies

Konuma

Kato

Ooi

et al. 2014

Bone Marrow Transplant

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“…These could include non-classical histocompatibility Ags that can be detected by NK cell receptors such as Qa-1, RAE-1, or Clr-b (32,33). Other possibilities include SIRPa (a polymorphic membrane protein expressed by monocytes, DCs, macrophages and neurons) (47) or a wide range of minor histocompatibility Ags that have been identified throughout the genome (48,49). Protease inhibition by serpins can influence coagulation and inflammation, so it could be surmised that polymorphisms among serpins may affect early responses.…”

Section: Discussionmentioning

confidence: 99%

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

Chow

Delconte

Huntington

et al. 2016

The Journal of Immunology

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Although the mechanisms governing the innate recognition of pathogen-associated molecular patterns have been well defined, how allogeneic cellular stimuli evoke innate responses remains less so. In this article, we report that upon i.v. transfer (to avoid major iatrogenic interference), allogeneic but not syngeneic leukocytes could induce a rapid (after 1 d) accumulation of host monocyte–derived dendritic cells (moDCs) without any increase in conventional DCs. This occurred in various donor–host strain combinations, did not require MHC mismatch, and could be induced by various donor cell types including B cells, T cells, or NK cells. Using RAG−/−γc−/− and scid γc−/−mice with different MHC, we found that the presence of either donor or host lymphoid cells was required. Alloinduced moDC accumulation was significantly reduced when splenocytes from mice deficient in NK cells by genetic ablation were used as donors. A major component of this moDC accumulation appears to be recruitment. Our findings provide new insights into how the innate and adaptive immune system may interact during allogeneic encounters and thus transplant rejection.

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“…Presented in the context of HLA molecules, MiHAs are peptides derived from polymorphic proteins that differ between individuals due to genomic single nucleotide polymorphisms (SNP; refs. [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Characterization of 10 New Minor Histocompatibility Antigens by Whole Genome Association Scanning

et al. 2010

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Patients with malignant diseases can be effectively treated with allogeneic hematopoietic stem cell transplantation (allo-SCT). Polymorphic peptides presented in HLA molecules, the so-called minor histocompatibility antigens (MiHA), play a crucial role in antitumor immunity as targets for alloreactive donor T cells. Identification of multiple MiHAs is essential to understand and manipulate the development of clinical responses after allo-SCT. In this study, CD8+ T-cell clones were isolated from leukemia patients who entered complete remission after allo-SCT, and MiHA-specific T-cell clones were efficiently selected for analysis of recognition of a panel of EBV-transformed B cells positive for the HLA restriction elements of the selected T-cell clones. One million single nucleotide polymorphisms (SNP) were determined in the panel cell lines and investigated for matching with the T-cell recognition data by whole genome association scanning (WGAs). Significant association with 12 genomic regions was found, and detailed analysis of genes located within these genomic regions revealed SNP disparities encoding polymorphic peptides in 10 cases. Differential recognition of patient-type, but not donor-type, peptides validated the identification of these MiHAs. Using tetramers, distinct populations of MiHA-specific CD8 + T cells were detected, demonstrating that our WGAs strategy allows high-throughput discovery of relevant targets in antitumor immunity after allo-SCT.

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The relevance of minor histocompatibility antigens in solid organ transplantation

Cited by 72 publications

References 70 publications

Impact of sex incompatibility on the outcome of single-unit cord blood transplantation for adult patients with hematological malignancies

Impact of sex incompatibility on the outcome of single-unit cord blood transplantation for adult patients with hematological malignancies

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells

High-Throughput Characterization of 10 New Minor Histocompatibility Antigens by Whole Genome Association Scanning

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