The relevance of Fas/Fas ligand axis in the tumor microenvironment of salivary gland adenoid cystic carcinoma

Kuchař, Martin; Střížová, Zuzana; Votava, Michal; Plzák, Jan

doi:10.1016/j.oraloncology.2019.08.015

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 b, FasR + CD4 and CD8 + T cells were more abundant in the tissue compartments of RCC patients than in the peripheral blood of healthy controls. This finding aligns with prior studies that underscore the crucial role of the Fas-Fas ligand axis in the tumor microenvironment (TME) [ 32 , 33 ].…”

Section: Resultssupporting

confidence: 91%

Distinct leukocyte populations and cytokine secretion profiles define tumoral and peritumoral areas in renal cell carcinoma

Borcinova,

Bartolini,

Foley

et al. 2024

Translational Oncology

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 91%

Distinct leukocyte populations and cytokine secretion profiles define tumoral and peritumoral areas in renal cell carcinoma

Borcinova,

Bartolini,

Foley

et al. 2024

Translational Oncology

View full text Add to dashboard Cite

“…However, being deeply immersed in immune system regulation and participating in the antitumor response, mainly by affecting many distinct immune cell populations, the harvesting of the regulatory powers of miR-155 for cancer therapy needs to be reconsidered based on the implementation of novel therapeutic algorithms. These algorithms should stem not only from the disease severity, including the tumor staging and grading, but also from the tumoral/paratumoral immune signatures inflicted by the disease or its treatment [ 152 , 153 , 154 , 155 , 156 ]. Guided by these signatures, the design of the therapeutic algorithm could then even include both miR-155 downregulation and upregulation, each corresponding to the time of treatment and the type of therapeutic modality.…”

Section: Future Perspectivesmentioning

confidence: 99%

The Role of miR-155 in Antitumor Immunity

Kalkusova

Taborska

Stakheev

et al. 2022

Cancers

View full text Add to dashboard Cite

MicroRNAs belong to a group of short non-coding RNA molecules that are involved in the regulation of gene expression at multiple levels. Their function was described two decades ago, and, since then, microRNAs have become a rapidly developing field of research. Their participation in the regulation of cellular processes, such as proliferation, apoptosis, cell growth, and migration, made microRNAs attractive for cancer research. Moreover, as a single microRNA can simultaneously target multiple molecules, microRNAs offer a unique advantage in regulating multiple cellular processes in different cell types. Many of these cell types are tumor cells and the cells of the immune system. One of the most studied microRNAs in the context of cancer and the immune system is miR-155. MiR-155 plays a role in modulating innate and adaptive immune mechanisms in distinct immune cell types. As such, miR-155 can be part of the communication between the tumor and immune cells and thus impact the process of tumor immunoediting. Several studies have already revealed its effect on antitumor immune responses, and the targeting of this molecule is increasingly implemented in cancer immunotherapy. In this review, we discuss the current knowledge of miR-155 in the regulation of antitumor immunity and the shaping of the tumor microenvironment, and the plausible implementation of miR-155 targeting in cancer therapy.

show abstract