The Relevance of Contralateral Recordings and Patient Disability to Assessment of Brain-Stem Auditory Evoked Potential Abnormalities in Multiple Sclerosis

Hammond, S. R.; Yiannikas, Con

doi:10.1001/archneur.1987.00520160024009

Cited by 15 publications

(4 citation statements)

References 48 publications

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“…24 BAEP have been found more frequently to be abnormal in patients with clinical signs of brainstem dysfunction. 18,24,25 Median nerve SEP correlate well with clinical disability. 24 In previous studies a statistical correlation was found between detrusor hyperactivity or detrusor hypoactivity with disease duration, disability and neurophysiological ®ndings.…”

Section: Discussionmentioning

confidence: 98%

The usefulness of the somatosensory evoked potentials of the pudendal nerve in diagnosis of probable multiple sclerosis

Siracusano

Aiello

et al. 1999

Spinal Cord

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Study design: The aim of the study was to evaluate the sensitivity of pSEP in patients a ected by probable MS. Objectives: Bladder dysfunction is the presenting symptom in 2% of patients a ected by multiple sclerosis (MS) and may be present in up to 78% of them. Abnormalities of somatosensory evoked potentials of the pudendal nerve (pSEP) have been found by many authors in patients a ected by clinically de®ned MS, but little is known of diagnostic reliability of pSEP in early stage of MS. Methods: Sixteen patients, eleven females and ®ve males, aged between 18 and 45 years old (mean age 28.9), a ected by clinically probable MS, were studied. Six of them reported retention or urge incontinence. pSEP with P1 (P40) scalp wave was analyzed. All patients also underwent visual evoked potentials (VEP), SEP of median and tibial nerves (mSEP, tSEP), brainstem acoustic evoked potentials (BAEPs), MRI of the brain and cerebrospinal¯uid (CSF) evaluation. Urodynamic study with simultaneous measurement of intravesical, intraurethral and abdominal pressures with external sphincter electromyography was performed. Results: Abnormalities of the evoked potentials were found in all patients. Abnormalities of the pSEP were observed in all the symptomatic cases and in eight of the remaining ten patients; ten showed no responses from the scalp and four showed P1 increased latency. Urodynamic abnormalities were found in 12 patients and MRI showed demyelinating lesions in 13 patients and oligoclonal bands were found in eight of them. Conclusion: pSEP can be worthwhile as part of the initial diagnostic evaluation in patients a ected by MS. It provides information of diagnostic relevance and plays a role in screening patients for urodynamic testing, which, however, is more speci®c for detecting urethrovesical dysfunctions and preventing urological complications.

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Section: Discussionmentioning

confidence: 98%

The usefulness of the somatosensory evoked potentials of the pudendal nerve in diagnosis of probable multiple sclerosis

Siracusano

Aiello

et al. 1999

Spinal Cord

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“…Contralateral recording is not thought to contribute significantly to lesion detection; the main value is to aid in the recognition of certain waves when they are not clearly visible in the ipsilateral recording [18]. Hatanaka and associates [19] suggested that contralateral recordings can be a useful measure of developmental changes in the infant auditory pathway.…”

Section: Discussionmentioning

confidence: 99%

Ipsilateral and Contralateral Auditory Brainstem Response Reorganization in Hemispherectomized Patients

Yao

Qiao

et al. 2013

Neural Plasticity

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Background. Cortical hemispherectomy leads to degeneration of ipsilateral subcortical structures, which can be observed long term after the operation. Therefore, reorganization of the brainstem auditory pathway might occur. The aim of this study was to assess reorganization of brainstem auditory pathways by measuring the auditory brainstem response (ABR) in long-term hemispherectomized patients. Methods. We performed bilateral monaural stimulation and measured bilateral ABR in 8 patients ~20 years after hemispherectomy and 10 control subjects. Magnetic resonance imaging (MRI) was performed in patients to assess structural degeneration. Results. All patients showed degenerated ipsilateral brainstem structures by MRI but no significant differences in bilateral recording ABR wave latencies. However, nonsurgical-side stimulation elicited significantly longer wave V latencies compared to surgical-side stimulation. Differences in bilateral ABR were observed between hemispherectomized patients and control subjects. Waves III and V latencies elicited by nonsurgical-side stimulation were significantly longer than those in control subjects; surgical-side stimulation showed no significant differences. Conclusions. (1) Differences in ABR latency elicited by unilateral stimulation are predominantly due to bilateral brainstem auditory pathway activity rather than to changes in brainstem volume; (2) ABR Waves III and V originate predominantly in the contralateral brainstem; and (3) subcortical auditory pathways appear to reorganize after long term hemispherectomy.

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“…Several investigators have since documented the need for using monaural stimulation to identify patients with lateralized lesions (Barajas, 1982;Prasher and Gibson, 1980;Rowe, 1981). In addition, Hammond and Yiannikas (1987) have recently reported aberrant contralaterally recorded ABR responses in MS. Abnormalities consisted of a delayed or absent contralateral wave peak components in 7 of 83 patients. In addition, two publications ( Barajas, 1982;Prasher and Gibson, 1980) suggest that occasionally only contralateral stimulation results in an abnormally late response in MS subjects.…”

Section: Polaritymentioning

confidence: 99%

“…Early studies by Rudge (1975, 1977), Starr and Achor (1975), and Shanon, Gold, Himmelfarb, and Carasso SEMINARS IN HEARING-VOLUME 11, NUMBER 3 August 1990Yagi and Kaga, 1979), abnormal intensity-latency functions (Parving, Elberling, and Smith, 1981) and abnormal contralateral recordings (Hammond and Yiannikas, 1987).…”

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confidence: 99%

The Auditory Brainstem Response in Multiple Sclerosis

Jacobson¹,

Jacobson²

1990

Semin Hear

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The Relevance of Contralateral Recordings and Patient Disability to Assessment of Brain-Stem Auditory Evoked Potential Abnormalities in Multiple Sclerosis

Cited by 15 publications

References 48 publications

The usefulness of the somatosensory evoked potentials of the pudendal nerve in diagnosis of probable multiple sclerosis

The usefulness of the somatosensory evoked potentials of the pudendal nerve in diagnosis of probable multiple sclerosis

Ipsilateral and Contralateral Auditory Brainstem Response Reorganization in Hemispherectomized Patients

The Auditory Brainstem Response in Multiple Sclerosis

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