The relevance of biomaterials to the prevention and treatment of osteoporosis

Arcos, Daniel; Boccaccını, Aldo R.; Bohner, Marc; Díez-Pérez, Adolfo; Epple, Matthias; Gómez‐Barrena, Enrique; Herrera, Antonio; Planell, Josep A.; Rodríguez‐Mañas, Leocadio; Vallet‐Regí, María

doi:10.1016/j.actbio.2014.01.004

Cited by 124 publications

(73 citation statements)

References 163 publications

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“…More recently, the use of monoclonal antibody for sclerostin or receptor activator of the nuclear factor kappa B ligand (RANKL), and the delivery of small interfering RNA (siRNA) have also been use for the treatment of OP [4,[9][10][11][12]. Furthermore, implantable biomaterials that incorporate drugs for targeting osteoclasts have been developed to treat OP [13,14].…”

Section: Introductionmentioning

confidence: 98%

Inhibition of osteoclastogenesis through siRNA delivery with tunable mesoporous bioactive nanocarriers

et al. 2016

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Section: Introductionmentioning

confidence: 98%

Inhibition of osteoclastogenesis through siRNA delivery with tunable mesoporous bioactive nanocarriers

et al. 2016

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“…The risk of fracture, non-union and aseptic implant loosening is significantly increased for osteoporotic fracture patients due to the impaired response of the bone microenvironment to the endosseous implant material. However, there are no materials specifically tailored for application in osteoporotic bone [3], although several reports have advocated combining fracture treatment with pharmaceutical therapies and claimed promising effects in preventing secondary fractures in postmenopausal women [4,5].…”

Section: Introductionmentioning

confidence: 99%

Alkaline biodegradable implants for osteoporotic bone defects—importance of microenvironment pH

et al. 2015

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Change of microenvironment pH by biodegradable implants may ameliorate unbalanced osteoporotic bone remodeling. The present work demonstrated that a weak alkaline condition stimulated osteoblasts differentiation while suppressed osteoclast generation. In vivo, implants with an alkaline microenvironment pH (monitored by a pH microelectrode) exhibited a promising healing effect for the repair of osteoporotic bone defects. Introduction Under osteoporotic conditions, the response of the bone microenvironment to an endosseous implant is significantly impaired, and this substantially increases the risk of fracture, non-union and aseptic implant loosening. Acid-base equilibrium is an important factor influencing bone cell behaviour. The present purpose was to study the effect of a series of alkaline biodegradable implant materials on regeneration of osteoporotic bone defect, monitoring the microenvironment pH (μe-pH) over time.Methods The proliferation and differentiation potential of osteoporotic rat bone marrow stromal cells and RAW 264.7 cells were examined under various pH conditions. Ovariectomized rat bone defects were filled with specific biodegradable materials, and μe-pH was measured by pH microelectrode. New osteoid and tartrate-resistant acid phosphatase-positive osteoclast-like cells were examined by Goldner's trichrome and TRAP staining, respectively. The intermediate layer between implants and new bone were studied using energy-dispersive X-ray spectroscopy (EDX) linear scanning. Results In vitro, weak alkaline conditions stimulated osteoporotic rat bone marrow stromal cells (oBMSC) differentiation, while inhibiting the formation of osteoclasts. In vivo, μe-pH differs from that of the homogeneous peripheral blood and exhibits variations over time particular to each material. Higher initial μe-pH was associated with more new bone formation, late response of TRAP-positive osteoclast-like cells and the development of an intermediate 'apatitic' layer in vivo. EDX suggested that residual material may influence μe-pH even 9 weeks post-surgery. Conclusion The pH microelectrode is suitable for in vivo μe-pH detection. Alkaline biodegradable materials generate an in vivo microenvironmental pH which is higher than the normal physiological value and show promising healing effects in the context of osteoporotic bone defects.

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“…The main aim of tissue engineering -a branch of the sciences that unites Materials Engineering and Biomedicine -is the production of materials that can substitute and/or induce advanced regenerative processes in damaged tissue 1 . Mechanical, industrial, biological and clinical aspects are taken into consideration such as biocompatibility, bioactivity, recruiting capacity and induction of cellular differentiation.…”

Section: Introductionmentioning

confidence: 99%

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Almeida¹,

Silva²,

Nakamura³

et al. 2015

Mat. Res.

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Aragonite is a metastable polymorph of calcium carbonate found in mollusk's shells, appearing in tiles and prismatic columns, cemented in a protein matrix -mainly proteins -that acts as a framework on which the aragonite is nucleated forming nacre, besides selecting the morphology of the nucleated cristaline phase. The presence of the mineralyzing organic matrix may affect osteoinductive properties of biogenic aragonite, hypothesis tested by combinated tests, comparing viability and bioactivity of biomineralizated aragonite and nacre. Bioactivity was observed by deposition of Ca-P (presumably calcium phosphate) on the surface of samples immersed in Simulated Body Fluid; biocompatibility was verified by adhesion with VERO cells; cytotoxicity and alkaline phosphatase activity assays were performed with human adipose stem cells (hASC). Samples were characterized by scanning electron microscopy and X-ray diffraction. Both materials showed similar behaviour on bioactivity assay; in contrast, exhibited different behaviours in the presence of hASC.

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The relevance of biomaterials to the prevention and treatment of osteoporosis

Cited by 124 publications

References 163 publications

Inhibition of osteoclastogenesis through siRNA delivery with tunable mesoporous bioactive nanocarriers

Inhibition of osteoclastogenesis through siRNA delivery with tunable mesoporous bioactive nanocarriers

Alkaline biodegradable implants for osteoporotic bone defects—importance of microenvironment pH

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

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