The relevance and treatment of cue-induced cravings in tobacco dependence

Ferguson, Stuart G.; Shiffman, Saul

doi:10.1016/j.jsat.2008.06.005

Cited by 311 publications

(271 citation statements)

References 75 publications

(108 reference statements)

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“…Clofibrate's ability to counteract nicotinerelated cues is consistent with the findings that PPARa agonists downregulate nicotinic receptors and that cue-induced nicotine-seeking depends upon the action of acetylcholine at nicotinic receptors (Liu et al, 2007). If clofibrate can indeed counteract the effects of smoking-related cues, this could make it a valuable adjunct or alternative to bupropion, varenicline, and nicotine patch therapies, which do not appear to protect against cueinduced nicotine craving in humans (Ferguson and Shiffman, 2009) or cue-induced nicotine-seeking in rats (Wouda et al, 2011;Liu et al, 2008). …”

Section: Discussionsupporting

confidence: 69%

Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

Panlilio

Justinová

Mascia

et al. 2012

Neuropsychopharmacol

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Experimental drugs that activate a-type peroxisome proliferator-activated receptors (PPARa) have recently been shown to reduce the rewarding effects of nicotine in animals, but these drugs have not been approved for human use. The fibrates are a class of PPARa-activating medications that are widely prescribed to improve lipid profiles and prevent cardiovascular disease, but these drugs have not been tested in animal models of nicotine reward. Here, we examine the effects of clofibrate, a representative of the fibrate class, on reward-related behavioral, electrophysiological, and neurochemical effects of nicotine in rats and squirrel monkeys. Clofibrate prevented the acquisition of nicotine-taking behavior in naive animals, substantially decreased nicotine taking in experienced animals, and counteracted the relapse-inducing effects of re-exposure to nicotine or nicotine-associated cues after a period of abstinence. In the central nervous system, clofibrate blocked nicotine's effects on neuronal firing in the ventral tegmental area and on dopamine release in the nucleus accumbens shell. All of these results suggest that fibrate medications might promote smoking cessation. The fact that fibrates are already approved for human use could expedite clinical trials and subsequent implementation of fibrates as a treatment for tobacco dependence, especially in smokers with abnormal lipid profiles.

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Section: Discussionsupporting

confidence: 69%

Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

Panlilio

Justinová

Mascia

et al. 2012

Neuropsychopharmacol

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“…Highly addicted smokers motivated to quit are often only able to quit smoking for a few hours (Shiffman et al, 2006), suggesting greater vulnerability to craving and/or withdrawal symptoms. Effective modulation of cue-elicited craving is crucial to successful smoking cessation, as most first-line pharmacotherapies are minimally effective at attenuating the cue-elicited craving that frequently leads to smoking lapses (Ferguson & Shiffman, 2009;Tiffany, Cox, & Elash, 2000). It is possible that an alternative feedback paradigm could aid highly dependent individuals in controlling craving.…”

Section: Discussionmentioning

confidence: 99%

“…Cigarette craving is a key factor contributing to relapse among smokers attempting abstinence (Allen, Bade, Hatsukami, & Center, 2008;Ferguson & Shiffman, 2009;Killen & Fortmann, 1997), and therapies that help smokers control their craving may facilitate smoking cessation. Neurofeedback, delivered via real-time functional magnetic resonance imaging (rtfMRI), can facilitate self-regulation of internal states by providing feedback from localized regions of interest (ROIs) to individuals while performing a task Weiskopf, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sustained Reduction of Nicotine Craving With Real-Time Neurofeedback: Exploring the Role of Severity of Dependence

Canterberry

Hanlon

Hartwell

et al. 2013

Nicotine &Amp; Tobacco Research

116

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Background: Neurofeedback delivered via real-time functional magnetic resonance imaging (rtfMRI) is a promising therapeutic technique being explored to facilitate self-regulation of craving in nicotine-dependent cigarette smokers. The current study examined the role of nicotine-dependence severity and the efficacy of multiple visits of neurofeedback from a single region of interest (ROI) in the anterior cingulate cortex (ACC) on craving reduction.

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“…3,4 Pharmacological interventions do not appear to be effective in protecting smokers from urges related to cueinduced craving. 5 Therefore, there is a need for treatments that deal with the effect of cue-induced craving. Cue Exposure Therapy (CET) consists of controlled and repeated exposure to drug-related cues, in order to reduce craving associated with these situations by extinction.…”

mentioning

confidence: 99%

Identifying Specific Cues and Contexts Related to Smoking Craving for the Development of Effective Virtual Environments

García–Rodríguez

Ferrer-García

Pericot‐Valverde

et al. 2011

Cyberpsychology, Behavior, and Social Networking

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Craving is considered the main variable associated with relapse after smoking cessation. Cue Exposure Therapy (CET) consists of controlled and repeated exposure to drug-related cues with the aim of extinguishing craving responses. Some virtual reality (VR) environments, such as virtual bars or parties, have previously shown their efficacy as tools for eliciting smoking craving. However, in order to adapt this technology to smoking cessation interventions, there is a need for more diverse environments that enhance the probability of generalization of extinction in real life. The main objective of this study was to identify frequent situations that produce smoking craving, as well as detecting specific craving cues in those contexts. Participants were 154 smokers who responded to an ad hoc self-administered inventory for assessing craving level in 12 different situations. Results showed that having a drink in a bar/pub at night, after having lunch/dinner in a restaurant and having a coffee in a cafe or after lunch/dinner at home were reported as the most craving-inducing scenarios. Some differences were found with regard to participants' gender, age, and number of cigarettes smoked per day. Females, younger people, and heavier smokers reported higher levels of craving in most situations. In general, the most widely cited specific cues across the contexts were people smoking, having a coffee, being with friends, and having finished eating. These results are discussed with a view to their consideration in the design of valid and reliable VR environments that could be used in the treatment of nicotine addicts who wish to give up smoking.

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The relevance and treatment of cue-induced cravings in tobacco dependence

Cited by 311 publications

References 75 publications

Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

Sustained Reduction of Nicotine Craving With Real-Time Neurofeedback: Exploring the Role of Severity of Dependence

Identifying Specific Cues and Contexts Related to Smoking Craving for the Development of Effective Virtual Environments

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