The Relative Potency of Oral Transmucosal Fentanyl Citrate Compared with Intravenous Morphine in the Treatment of Moderate to Severe Postoperative Pain

Lichtor, J. Lance; Sevarino, Ferne B.; Joshi, Girish P.; Busch, Michael; Nordbrock, Earl; Ginsberg, Brian

doi:10.1213/00000539-199909000-00038

Cited by 76 publications

(30 citation statements)

References 11 publications

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“…It has been calculated that the oral transmucosal fentanyl citrate (OTFC): intravenous morphine (IVMO) ratio is 1:10e20. 30,31 In a previous study, a ratio of OTFC:IVMO 1:20 was used, after preliminary testing. 22 For example, the initial dose of OTFC for patients who receive 60 mg of equivalent doses of OM is commonly 200 mg. With an availability of about 25%e30%, it corresponds to 50e60 mg.…”

Section: Discussionmentioning

confidence: 99%

Fentanyl Pectin Nasal Spray Versus Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Comparative Study

Mercadante

Aielli

Adile

et al. 2016

Journal of Pain and Symptom Management

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Section: Discussionmentioning

confidence: 99%

Fentanyl Pectin Nasal Spray Versus Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Comparative Study

Mercadante

Aielli

Adile

et al. 2016

Journal of Pain and Symptom Management

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“…This does not mean that the dose of the two drugs is equianalgesic, despite some information drawn from previous local experience and studies performed in other settings (Lichtor et al, 1999).…”

Section: Methodsmentioning

confidence: 95%

“…In postoperative studies, it has been calculated that OTFC:IV-MO ratio is 1 : 10 -20 (Lichtor et al, 1999;Lu and Bailey, 2003). However, this group of patients were opioid-naive, and no comparison can be carried out with the present results.…”

Section: Intravenous Morphine and Otfc Doses S Mercadante Et Almentioning

confidence: 99%

Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain

et al. 2007

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The use of supplemental doses of opioids is commonly suggested to manage breakthrough pain. A comparative study of intravenous morphine (IV-MO) and oral transmucosal fentanyl citrate (OTFC) given in doses proportional to the basal opioid regimen was performed in 25 cancer patients receiving stable opioid doses. For each episode, when it occurred and 15 and 30 min after the treatment, pain intensity and opioid-related symptoms were recorded. Fifty-three couples of breakthrough events, each treated with IV-MO and OTFC, were recorded. In episodes treated with IV-MO, pain intensity decreased from a mean of 6.9 to 3.3 and to 1.7 at T1 and T2, respectively. In episodes treated with OTFC, pain intensity decreased from a mean of 6.9 to 4.1 and to 2.4 at T1 and T2, respectively. Statistical differences between the two treatments were found at T1 (P ¼ 0.013), but not at T2 (P ¼ 0.059). Adverse effects were comparable and were not significantly related with the IV-MO and OTFC doses. Intravenous morphine and OTFC in doses proportional to the scheduled daily dose of opioids were both safe and effective, IV-MO having a shorter onset than OTFC. Future comparative studies with appropriate design should compare titration methods and proportional methods of OTFC dosing.

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“…In one randomized study, 133 postoperative patients were given one dose of either OTFC (200 or 800 mcg) and a placebo IV injection or IV morphine (2 or 10 mg) and an OTM placebo unit [65,66]. The OTFC was compared with IV morphine in terms of pain relief, pain intensity, time to pain relief, and time to remedication and it was found that OTFC produced rapid pain relief comparable to IV morphine.…”

Section: Non-cancer Painmentioning

confidence: 99%

Tablets and Other Solid Dosage Forms for Systemic Oral Mucosal Drug Delivery

Rane¹,

Moe²

2015

Advances in Delivery Science and Technology

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The Relative Potency of Oral Transmucosal Fentanyl Citrate Compared with Intravenous Morphine in the Treatment of Moderate to Severe Postoperative Pain

Cited by 76 publications

References 11 publications

Fentanyl Pectin Nasal Spray Versus Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Comparative Study

Fentanyl Pectin Nasal Spray Versus Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Comparative Study

Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain

Tablets and Other Solid Dosage Forms for Systemic Oral Mucosal Drug Delivery

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