The Relative Merits of Acute Phase Proteins in the Recognition of Inflammatory Conditions

Calvin, J.; Neale, G.; Fotherby, K.; Price, Christopher P.

doi:10.1177/000456328802500108

Cited by 51 publications

(33 citation statements)

References 21 publications

(12 reference statements)

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“…The fact that plasma PLP is inversely correlated with a 1 -antichymotrypsin, an index of acute phase status 22 in both age groups, suggests that acute phase status may be a major confounding factor, affecting plasma PLP at all ages. Since this is true even for plasma antichymotrypsin levels below 0.65 g l −1 , the effect seems not to be confined to severely abnormal acute phase status.…”

Section: Discussionmentioning

confidence: 99%

An appraisal of vitamin B₆status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

Bates

Pentieva

Prentice

1999

Public Health Nutr.

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Objective: To compare vitamin B 6 status indices with each other and with potential confounding factors, in the datasets from two national British surveys and associated studies. Design: Vitamin B 6 status was measured by plasma pyridoxal phosphate (PLP) and plasma pyridoxic acid (PA) in both surveys, and also by erythrocyte aspartate aminotransferase activation coefficient (EAATAC) in one of the surveys. Plasma a 1 -antichymotrypsin was measured as an index of acute phase status; plasma creatinine was measured as an index of renal function; and plasma total alkaline phosphatase activity was measured as a proxy for PLP hydrolase activity. Setting: The survey of people aged 65 years and over was carried out in 80 postcode sectors across mainland Britain during 1994-95 and the survey of young people was carried out in 132 postcode sectors across mainland Britain during 1997. Subjects: Blood samples from c. 1000 subjects of both sexes in each survey permitted measurements of plasma PLP and PA. There were also measurements of EAATAC in the young people's survey. Results: According to published limits of normality, only 5% or less of the young people had unacceptable vitamin B 6 status as measured by plasma PLP. About half had apparently unacceptable status by EAATAC, but this observation is difficult to interpret. The young people had considerably higher plasma concentrations of PLP and lower concentrations of PA than the older people. In both surveys, plasma PLP was strongly correlated with plasma PA and in the young persons' survey it was also correlated, although much less strongly, with the basal activity and activation coefficient of aspartate aminotransferase. Both plasma PLP and EAATAC (but not PA nor basal aspartate aminotransferase activity) were influenced by acute phase status in young people, as indicated by significant correlations with a 1 -antichymotrypsin. In people aged 65 years and over, PA (but not PLP) was correlated with renal function, as indicated by its relation with plasma creatinine; however PLP (but not PA) was correlated with plasma alkaline phosphatase activity.

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Section: Discussionmentioning

confidence: 99%

An appraisal of vitamin B₆status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

Bates

Pentieva

Prentice

1999

Public Health Nutr.

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“…Plasma urea and creatinine were measured on a Roche Cobas Bio centrifugal analyser with Roche kit reagents 10 ; plasma a 1 -antichymotrypsin were measured on the same analyser, with Dako Ltd (High Wycombe, Bucks, UK) reagents 10 . The choice of a 1 -antichymotrypsin as an acute phase marker has been validated 14 . Diet records were coded at SCPR and were used to calculate individual daily nutrient intakes from tables, using a specially developed nutrient databank, based on standard food composition tables.…”

Section: Methodsmentioning

confidence: 99%

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Bates

Walmsley

Prentice

et al. 1999

Public Health Nutr.

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Objective: To describe the extent of use of medicines by older people living in Britain, and to explore relationships with vitamin status indices. Design: The National Diet and Nutrition Survey of people aged 65 years and over collected data from a British sample during 1994-95. The present study has made novel use of it, to relate medicine use with biochemical indices of vitamin status. Setting: Eighty postcode areas, selected randomly from mainland Britain. Subjects: 1506 people, 65 years and over gave information about use of medication, and a 4-day weighed food record. Three-quarters gave blood for status indices. Results: 78% of those living in the community and 93% of those in institutions were using medication. Certain vitamin status indices: plasma retinol, erythrocyte folate and riboflavin, paradoxically suggested better status in users than in non-users of antihypertensive, gastrointestinal, central nervous system, corticosteroid or diabetic drugs. There was evidence of a link with renal insufficiency, especially for plasma retinol, but neither this nor increased nutrient intake, acute phase effects or haemoconcentration could explain the paradoxical associations. Conclusions: Caution is needed in interpreting certain vitamin status indices, especially in older people who are extensively using medicines. New vitamin indices are needed, to avoid confounding interferences.

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“…Albumin was assayed by using antibodies from Incstar (Winnersh, Buckinghamshire, United Kingdom) and Seronorm standards (Nycomed, Birmingham, United Kingdom). ACT is a marker of the acute phase reaction that can indicate acute, chronic, and subclinical infections (35,36). ACT was measured by using Dako (High Wycombe, Buckinghamshire, United Kingdom) antibodies with Serotec (Kidlington, Oxon, United Kingdom) calibrators according to the method of Calvin and Price (35).…”

Section: Plasma Proteinsmentioning

confidence: 99%

Anthelmintic treatment of rural Bangladeshi children: effect on host physiology, growth, and biochemical status

Northrop-Clewes

Rousham²,

Mascie‐Taylor³

et al. 2001

The American Journal of Clinical Nutrition

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Background:The effect of helminth infestation on the nutrition, growth, and physiology of the host is still poorly understood. Anthelmintic treatment of children in developing countries has had varying success in terms of growth improvements. Objective: The objective of this study was to assess the effect of regular deworming on child growth, physiology, and biochemical status. Design:The study was a 12-mo longitudinal intervention in 123 Bangladeshi children aged 2-5 y. Treatment (mebendazole) or placebo tablets were administered every 2 mo for 8 mo and again at 12 mo. Weight, height, midupper arm circumference, intestinal permeability, plasma albumin, ␣ 1 -antichymotrypsin, and total protein concentration were assessed every 2 mo. Results: Treatment with mebendazole reduced the prevalence of Ascaris lumbricoides from 78% to 8%, of Trichuris trichiura from 65% to 9%, and of hookworm from 4% to 0%. There was no significant difference in the growth of treated children compared with those given placebo tablets. No changes in intestinal permeability or plasma albumin were observed after deworming. Significant decreases in total protein (P < 0.001) and ␣ 1 -antichymotrypsin (P < 0.001) were observed in the treatment group, indicating possible reductions in inflammation and immunoglobulin concentration after deworming. A significant increase in the prevalence of Giardia intestinalis (from 4% to 49%) in the treatment group was associated with a short-term reduction in weight (P = 0.02) and higher intestinal permeability (P < 0.001) in infected subjects. No long-term effects of G. intestinalis on growth were observed. Conclusion: Low-intensity helminth infections, predominantly of A. lumbricoides and T. trichiura, do not contribute significantly to the poor growth and biochemical status of rural Bangladeshi children.Am J Clin Nutr 2001;73:53-60.

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The Relative Merits of Acute Phase Proteins in the Recognition of Inflammatory Conditions

Cited by 51 publications

References 21 publications

An appraisal of vitamin B₆status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

An appraisal of vitamin B₆status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Anthelmintic treatment of rural Bangladeshi children: effect on host physiology, growth, and biochemical status

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The Relative Merits of Acute Phase Proteins in the Recognition of Inflammatory Conditions

Cited by 51 publications

References 21 publications

An appraisal of vitamin B6status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

An appraisal of vitamin B6status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Anthelmintic treatment of rural Bangladeshi children: effect on host physiology, growth, and biochemical status

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An appraisal of vitamin B₆status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys

An appraisal of vitamin B₆status indices and associated confounders, in young people aged 4–18 years and in people aged 65 years and over, in two national British surveys