The Relative Antihypertensive Potency of Propranolol, Oxprenolol, Atenolol, and Metoprolol Given Once Daily

We conducted a population-based, case-control study to determine whether beta-blockers, used for the treatment of hypertension, prevent first events of coronary heart disease. Cases were patients who had high blood pressure treated with medicines and who presented in 1982 to 1984 with angina or fatal or nonfatal myocardial infarction. Controls were a probability sample of health maintenance organization patients with pharmacologically treated hypertension and free of coronary heart disease. Blinded to case-control status, we reviewed the medical records of the 248 cases and 737 controls. The health maintenance organization's computerized pharmacy database was used to ascertain the use of beta-blockers. Fewer cases than controls were taking beta-blockers. This difference was confined to those with nonfatal infarctions. After adjustment for confounding, the estimated relative risk was 0.62 (95% confidence interval, 0.39 to 0.99). Higher doses of beta-blockers conferred greater protection. We conclude that beta-blockers may prevent first events of nonfatal myocardial infarction in patients with high blood pressure.

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Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension

Wong

Boyda

Wright

2016

Cochrane Database of Systematic Reviews

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This review provides low quality evidence that in people with mild to moderate hypertension, beta-1 selective blockers lowered BP by an average of -10/-8 mmHg and reduced heart rate by 11 beats per minute as compared to placebo. The effect of beta-1 blockers at peak hours, -12/-9 mmHg, was greater than the reduction at trough hours, -8/-7 mmHg. Beta-1 selective blockers lowered BP by a greater magnitude than dual receptor beta-blockers and partial agonist beta-blockers, lowered BP similarly to nonselective beta-blockers. Beta-1 selective blockers lowered SBP by a similar degree and lowered DBP by a greater degree than diuretics, angiotensin converting enzyme inhibitors and angiotensin receptor blockers. Because DBP is lowered by a similar extent to SBP, beta-1 selective blockers do not reduce pulse pressure.

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The Relative Antihypertensive Potency of Propranolol, Oxprenolol, Atenolol, and Metoprolol Given Once Daily

Cited by 11 publications

References 10 publications

Lipid-soluble and water-soluble beta-blockers. Comparison of the central nervous system depressant effect

Lipid-soluble and water-soluble beta-blockers. Comparison of the central nervous system depressant effect

β-Blockers and Primary Prevention of Coronary Heart Disease in Patients With High Blood Pressure

Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension

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