The Relationships of Onset and Exacerbation of Pustulosis Palmaris et Plantaris to Smoking and Focal Infections

Abstract

Clinical data, including focal infection and habitual cigarette smoking, were obtained from 203 male patients with pustulosis palmaris et plantaris (PPP) (age: 43.3 +/- 13.4) and 266 female patients (age: 44.0 +/- 13.7) for the 20 years from 1975 through 1994 to evaluate the relationship between the onset or severity of PPP and smoking. Seasonal incidences of onset were also studied. The incidence of onset of PPP symptoms was highest in June, when it is the most humid in Japan, and lowest in December. The most common infectious disease associated with PPP was tonsillitis. The percentages of heavy smoking (more than 20 cigarettes per day) were 74.7% and 32.9% for male and female patients, while those in the normal control population in Japan were 37.2% and 9.8% for males and females. These results suggest that heavy smoking, tonsillitis, and seasonal factors such as high humidity and high temperature may be related to the onset and exacerbation of PPP.

Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis

“…In PPP, a focal infection such as tonsillitis is considered a major factor in the occurrence and persistence of PPP [29]. We confirmed the normal bacterial flora in their throat but no pathogenic bacterium such as Staphylococcus aureus or β-streptococcus.…”

An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway

“…Considering that BaP is present in tabacco smoke and in the surrounding environment, and that smoking is an aggravating factor in inflammatory skin diseases such as psoriasis [9][10][11][12], acne [13], and palmoplantar pustulosis [14][15][16], which are associated with neutrophil infiltration, we hypothesized that BaP might be capable of inducing interleukin (IL)-8 (a potent neutrophil chemoattractant) and other proinflammatory cyto/chemokines from normal human epidermal keratinocytes (NHEKs). The aim of the present study was to clarify whether or not BaP was able to activate AhR signaling pathways in NHEKs leading to ROS and proinflammatory cyto/chemokines production, which, to our knowledge, was previously unreported.…”

Dermatoses neutrofílicas: parte II

“…74 Tonsillectomy and eradication of Helicobacter pylori. 61,75,76 lead to improvement of the dermatosis and osteo-articular symptoms, if present. 75,76,77 The mechanism involved in the stimulation of cutaneous lesions in chronic infections is unknown.…”

“…In general, the disease is persistent and painful, causing the functional impairment of patients. [59][60][61][62] Because PPP shares some common features with pustular psoriasis, some authors consider it a localized form of this disease.…”

“…It is more common in places with hot and humid climate. [59][60][61] The prevalence of patients with PPP and classic psoriasis is about 10% . 50 Lesions are characterized by the presence of sterile pustules in the palmoplantar region, over apparently normal skin or skin with erythema and desquamation (Figure 3).…”