The relationships between hematogram and metabolic syndrome in elderly subgroups: A Taiwan cohort study

Chuang, Tsung-Ju; Liu, Jhih‐Syuan; Li, Pengfei; Chang, Hao‐Yu; Hsieh, Chang‐Hsun; Chang, Jia-Kan; Hung, Yi‐Jen; Pei, Dee; Liang, Yao-Jen; Chen, Yen‐Lin

doi:10.1016/j.archger.2015.11.006

Cited by 7 publications

(11 citation statements)

References 31 publications

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“…Due to the high association of diabetes with metabolic syndrome (MetS), the incidence of MetS increases with age and should be considered an important issue in the elderly individuals. Previous studies have reported high prevalence of MetS-related risk factors in elderly Taiwanese [14,15]. As such, the identification and treatment of patients with MetS would be an important approach to reduce morbidity and impairment in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese

Tang

Huang

et al. 2018

JCM

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Aging is a complex progression of biological processes and is the causal contributor to the development of diabetes mellitus (DM). DM is the most common degenerative disease and is the fifth leading cause of death in Taiwan, where the trend of DM mortality has been steadily increasing. Metabolomics, important branch of systems biology, has been mainly utilized to understand endogenous metabolites in biological systems and their dynamic changes as they relate to endogenous and exogenous factors. The purpose of this study was to elucidate the metabolomic profiles in elderly people and its relation to lipid disorder (LD). We collected 486 elderly individuals aged ≥65 years and performed untargeted and targeted metabolite analysis using nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography—mass spectrometry (LC/MS). Several metabolites, including branched-chain amino acids, alanine, glutamate and alpha-aminoadipic acid were elevated in LD compared to the control group. Based on multivariate analysis, four metabolites were selected in the best model to predict DM progression: phosphatidylcholine acyl-alkyl (PC ae) C34:3, PC ae C44:3, SM C24:1 and PCae C36:3. The combined area under the curve (AUC) of those metabolites (0.82) was better for DM classification than individual values. This study found that targeted metabolic signatures not only distinguish the LD within the control group but also differentiated DM from LD in elderly Taiwanese. These metabolites could indicate the nutritional status and act as potential metabolic biomarkers for the elderly in Taiwan.

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Section: Introductionmentioning

confidence: 99%

Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese

Tang

Huang

et al. 2018

JCM

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“…This reduction causes a tissue hypoxia, leading to metabolic changes, besides stimulating erythropoietin production and Hb synthesis (Chuang et al, 2016). In this sense, the Hb levels may be correlated to MetS and used to predict this syndrome in subjects (Chuang et al, 2016). Past studies showed that among various CVD risk factors associated with Hb levels are white blood cell counts, cigarette smoking, diastolic blood pressure, and serum albumin (Shimakawa & Bild, 1993).…”

Section: Parametersmentioning

confidence: 99%

“…Studies suggest a relationship between Hb levels and the risk of developing MetS (Chuang et al, 2016;Hu, Kuo, & Wu, 2016). It is important to emphasize that hypertrophy and hyperplasia are characteristic features of obesity and lead to a reduction in the blood supply to adipocytes, due to the adipocytes enlargement.…”

Section: Parametersmentioning

confidence: 99%

“…It is important to emphasize that hypertrophy and hyperplasia are characteristic features of obesity and lead to a reduction in the blood supply to adipocytes, due to the adipocytes enlargement. This reduction causes a tissue hypoxia, leading to metabolic changes, besides stimulating erythropoietin production and Hb synthesis (Chuang et al, 2016). In this sense, the Hb levels may be correlated to MetS and used to predict this syndrome in subjects (Chuang et al, 2016).…”

Section: Parametersmentioning

confidence: 99%

“…However, according to Li et al (2016), the process of colonization and establishment of microorganisms is complex and a function of the microorganism-microorganism and the microorganism-host relations. These researches stated that this process of colonization is so dynamic that not all bacteria are able to colonize an intestinal microbiota permanently.…”

Section: The Intestinal Microbiotamentioning

confidence: 99%

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Synbiotic aerated dessert: diet product development and evaluation of the intake effects in individuals with metabolic syndrome

Santos¹

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The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

Jialal

Adams‐Huet

2020

Diabetes Metabolism Res

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Aims The metabolic syndrome (MetS) is a major global problem, and inflammation and insulin resistance appear to be key underpinnings in this cardio‐metabolic cluster. MetS predisposes to an increased risk of diabetes and atherosclerotic cardiovascular disease (ASCVD). It has a procoagulant diathesis which included increased platelet activity and impaired fibrinolysis. High density lipoprotein (HDL) appears to be anti‐thrombotic. Accordingly, we examined the ratios between platelets to HDL‐cholesterol(C) and adiponectin (Adipo) in patients with nascent MetS without the confounding of diabetes, ASCVD and smoking to determine their validity as biomarkers of MetS. Methods Patients with nascent MetS (n = 58) and matched controls (n = 44) were recruited. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipids, insulin, and Adipo. Ratios of platelets to HDL‐C and Adipo were calculated. Results Following adjustment for adiposity, only the platelet: HDL ratio was significantly increased in MetS and increased with severity of MetS. Receiver operating characteristic curve analysis showed that the platelet: HDL‐C area under the curve (AUC) significantly added to both platelets and platelet lymphocyte ratio AUCs. Also the platelet: HDL‐C ratio correlated with all cardio‐metabolic features of MetS, high sensitivity C‐reactive protein, insulin resistance chemerin, and leptin. Conclusions The ratio of platelets: HDL‐C is significantly increased in patients with nascent MetS and appear to be a valid biomarker of MetS. It could also emerge as a biomarker for athero‐thrombotic risk. However, these preliminary findings need confirmation in large prospective studies.

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The relationships between hematogram and metabolic syndrome in elderly subgroups: A Taiwan cohort study

Cited by 7 publications

References 31 publications

Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese

Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese

Synbiotic aerated dessert: diet product development and evaluation of the intake effects in individuals with metabolic syndrome

The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

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