The Relationship of Wound Healing with Psoriasis and Multiple Sclerosis

Abstract

Better understanding of wound healing could lead to improved treatment(s) of multiple sclerosis (MS) and psoriasis (Pso). New concepts in the events of wound healing, such as the roles of the innate and adaptive immune systems, have generated targets for treating these debilitating diseases. That in MS and Pso defective wound healing is responsible for the diseases' progression has not been hypothesized to date. Impaired initiation of wound repair by oligodendrocyte precursor cells or oligodendrocytes may play a role in MS, and a lack of inhibition of the proliferative phase in wound healing may explain the pathophysiology involved in Pso.

Integrated bioinformatic analysis of differentially expressed genes and signaling pathways in plaque psoriasis

“…Our GO biological process enrichment results, especially with regard to upregulated genes, included immune responses, keratinization, inflammatory responses and keratinocyte differentiation, all of which are commonly accepted components of the pathogenesis and pathological changes of psoriasis. In addition, the enrichment in defense responses and responses to wound healing processes indicates two important psoriatic precipitating factors: infection (18) and trauma (Koebner phenomena) (19), respectively, both of which are associated with the activation of innate immunity involved in the initial pathogenesis of psoriasis (20). Additional reported risk factors include smoking (21), alcohol (22) and obesity (23).…”

Nano Medicine in Healing Chronic Wounds: Opportunities and Challenges

“…These properties enable tailored interactions within the wound microenvironment, influencing cellular responses and fostering an environment conducive to healing. [6] By exploring the mechanisms of these distinct types of nanoparticles, we gain insights into how nanotechnology can be precisely tailored to address the complexities of chronic wounds. The subsequent sections will further delve into the clinical applications, opportunities, challenges, and future directions in the integration of nanotechnology into chronic wound care.…”

“…Chronic wounds often exhibit impaired cellular functions, hindering the natural healing process . Nanoparticles, with their small size and high surface area, facilitate enhanced cellular uptake, ensuring a more efficient delivery of therapeutic agents to key cells involved in wound repair [10].. This enhanced cellular uptake addresses a critical aspect of chronic wounds, promoting the activation of cellular processes necessary for an accelerated healing response.…”