The relationship of whole human vertebral body creep to geometric, microstructural, and material properties

Oravec, D; Kim, Woong; Flynn, Michael J.; Yeni, Yener N.

doi:10.1016/j.jbiomech.2018.03.021

Cited by 13 publications

(4 citation statements)

References 47 publications

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“…Furthermore, only studies on trabecular bone tissue were investigated, in total 27 publications. Therefore, studies on whole vertebrae, for example, Dall'Ara et al, 22 McBroom et al, 46 Oravec et al, 47 and Fields et al 48 were excluded. All studies in this review were performed at the thoracic‐lumbar region.…”

Section: Methodsmentioning

confidence: 99%

Density and mechanical properties of vertebral trabecular bone—A review

Öhman‐Mägi

Holub

et al. 2021

JOR Spine

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Being able to predict the mechanical properties of vertebrae in patients with osteoporosis and other relevant pathologies is essential to prevent fractures and to develop the most favorable fracture treatments. Furthermore, a reliable prediction is important for developing more patient-and pathology-specific biomaterials. A plethora of studies correlating bone density to mechanical properties has been reported; however, the results are variable, due to a variety of factors, including anatomical site and methodological differences. The aim of this study was to provide a comprehensive literature review on density and mechanical properties of human vertebral trabecular bone as well as relationships found between these properties. A literature search was performed to include studies, which investigated mechanical properties and bone density of trabecular bone. Only studies on vertebral trabecular bone tissue, reporting bone density or mechanical properties, were kept.A large variation in reported vertebral trabecular bone densities, mechanical properties, and relationships between the two was found, as exemplified by values varying between 0.09 and 0.35 g/cm 3 for the wet apparent density and from 0.1 to 976 MPa for the elastic modulus. The differences were found to reflect variations in experimental and analytical processes that had been used, including testing protocol and specimen geometry. The variability in the data decreased in studies where bone tissue testing occurred in a standardized manner (eg, the reported differences in average elastic modulus decreased from 400% to 10%). It is important to take this variability into account when analyzing the predictions found in the literature, for example, to calculate fracture risk, and it is recommended to use the models suggested in the present review to reduce data variability.

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Section: Methodsmentioning

confidence: 99%

Density and mechanical properties of vertebral trabecular bone—A review

Öhman‐Mägi

Holub

et al. 2021

JOR Spine

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“…Reasons can be attributed to the different structures of natural IVDs and the PVA-BC composite: the former consisted of upper and lower VBs, and the sandwiched IVD (upper right in Figure 4), while the latter only contained the PVA-BC composite, which functioned merely as the IVD. The compressive stiffness calculated based on the sandwich structures of natural IVDs took the stiffness of VBs into account, resulting in a higher value compared with the pure PVA-BC composite [67,68], and was not used as the decisive parameter for the optimal formulation.…”

Section: Discussionmentioning

confidence: 99%

An Artificial PVA-BC Composite That Mimics the Biomechanical Properties and Structure of a Natural Intervertebral Disc

et al. 2022

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Disc herniation is one of the most ubiquitous healthcare problems in modern cities—severe patients eventually require surgical intervention. However, the existing operations—spinal fusion and artificial disc replacement—alter the biomechanics of the spine, leaving much room for improvement. The appropriateness of polyvinyl alcohol (PVA) for biomedical applications has been recognised due to its high water content, excellent biocompatibility, and versatile mechanical properties in the area of artificial cartilage and knee meniscus. In this study, a newly-designed PVA–bacterial cellulose (PVA-BC) composite was assembled to mimic both the biomechanics and annular structure of natural intervertebral discs (IVDs). PVA-BC composites of various concentrations were fabricated and tested under unconfined compression and compressive creep in order to acquire the values of the normalised compressive stiffness and whole normalised deformation. The normalised compressive stiffness increased considerably with an increasing PVA concentration, spanning from 1.82 (±0.18) to 3.50 (±0.14) MPa, and the whole normalised deformation decreased from 0.25 to 0.13. Formulations of 40% PVA provided the most accurate mimicry of natural human IVDs in normalised whole deformation, and demonstrated higher dimensional stability. The biocompatible results further confirmed that the materials had excellent biocompatibility. The novel bionic structure and formulations of the PVA-BC materials mimicked the biomechanics and structure of natural IVDs, and ensured dimensional stability under prolonged compression, reducing the risk of impingement on the surrounding tissue. The PVA-BC composite is a promising material for third-generation artificial IVDs with integrated construction.

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“…31 Also some structural-related parameters contributed little to the class prediction, including Conn.Dn, BS/BV and DA. Interestingly, these parameters have been shown to be closely related to mechanical bone properties, [32][33][34] which may indicate that more sparse structures are not always associated with poor mechanical properties and vice-versa. This is in agreement with previous studies on in vivo and ex vivo jaw bone biopsies that found a dependency of bone quality on BV/TV, Tb.Pf, Tb.N Tb.Sp and SMI and a less influence from Tb.Th.…”

Section: Discussionmentioning

confidence: 99%