The Relationship of Total Dust, Free Silica, and Trace Metal Concentrations to the Occupational Respiratory Disease of Bituminous Coal Miners

Sweet, D. V.; Crouse, William E.; Crable, John V.; Carlberg, John R.; Lainhart, William S.

doi:10.1080/0002889748507063

Cited by 21 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Irrespective of these variations, a somber realization arises from considering that the total accumulation of EC in the lungs of the coal miners in this study amounted to several grams in some cases. These values are similar to those reported for coal dust in the lungs of autopsied coal miners from the United States, using gravimetric analysis (Sweet et al, 1974).…”

Section: Discussionsupporting

confidence: 85%

Quantitative Assessment of Elemental Carbon In The Lungs of Never Smokers, Cigarette Smokers, and Coal Miners

Saxena

McClure

Hays

et al. 2011

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

Inhalation exposure to particulates such as cigarette smoke and coal dust is known to contribute to the development of chronic lung disease. The purpose of this study was to estimate the amount of elemental carbon (EC) deposits from autopsied lung samples from cigarette smokers, miners, and control subjects and explore the relationship between EC level, exposure history, and the extent of chronic lung disease. The samples comprised three subgroups representing never smokers (8), chronic cigarette smokers (26), and coal miners (6). Following the dissolution of lung tissue, the extracted EC residue was quantified using a thermal-optical transmission (TOT) carbon analyzer. Mean EC levels in the lungs of the control group were 56.68 ± 24.86 (SD) μg/g dry lung weight. Respective mean EC values in lung samples from the smokers and coal miners were 449.56 ± 320.3 μg/g and 6678.2 ± 6162 μg/g. These values were significantly higher than those obtained from the never-smoker group. EC levels in the lung and pack-years of cigarette smoking correlated significantly, as did EC levels and the severity of small airway disease. This study provides one of the first quantitative assessments of EC in human lungs from populations at high relative risk for the development of chronic lung disease.

show abstract

Section: Discussionsupporting

confidence: 85%

Quantitative Assessment of Elemental Carbon In The Lungs of Never Smokers, Cigarette Smokers, and Coal Miners

Saxena

McClure

Hays

et al. 2011

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

show abstract

“…For a subgroup of 141 miners, a 1.5-cm slice of lung adjacent to the whole lung section was analyzed gravimetrically for total dust, coal dust, total mineral dust, and free silica, as described previously (23,30,31). The percentage of dust (by weight) in 100 g of dry tissue was converted to mass of dust (g) per whole lung by assuming a ratio of 1/5 for dry/wet tissue and a mass of 1,000 g per human lung (left and right) at autopsy.…”

Section: Lung Dust Analysismentioning

confidence: 99%

Contributions of Dust Exposure and Cigarette Smoking to Emphysema Severity in Coal Miners in the United States

Kuempel¹,

Wheeler²,

Smith³

et al. 2009

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…Diseases due to inhalation of particulate matter encompass a wide spectrum of disorders including occupational lung diseases such as asbestosis and silicosis (2)(3)(4)(5) as well as nonoccupational disease states due to inhaled pollutants (6, 7). Diseases due to inhalation of particulate matter encompass a wide spectrum of disorders including occupational lung diseases such as asbestosis and silicosis (2)(3)(4)(5) as well as nonoccupational disease states due to inhaled pollutants (6, 7).…”

mentioning

confidence: 99%

Identification and Localization of Toxic Elements in Normal Human Lung Macrophages

Quan

Golde

1981

Experimental Biology and Medicine

View full text Add to dashboard Cite

Ahstract. The elemental content of pulmonary macrophages obtained by bronchopulmonary lavage from 13 healthy adult volunteers was assessed. Subcellular localization of elements was accomplished using energy-dispersive X-ray analysis in the scanning transmission microscope. Silicon, aluminum, iron, and sulfur were identified and localized to subcellular particles. These observations indicate that the elemental content of alveolar macrophages lavaged from living individuals can be determined by microanalysis and that the alveolar macrophages of normal persons retain potentially toxic elements. 175

show abstract

The Relationship of Total Dust, Free Silica, and Trace Metal Concentrations to the Occupational Respiratory Disease of Bituminous Coal Miners

Cited by 21 publications

References 8 publications

Quantitative Assessment of Elemental Carbon In The Lungs of Never Smokers, Cigarette Smokers, and Coal Miners

Quantitative Assessment of Elemental Carbon In The Lungs of Never Smokers, Cigarette Smokers, and Coal Miners

Contributions of Dust Exposure and Cigarette Smoking to Emphysema Severity in Coal Miners in the United States

Identification and Localization of Toxic Elements in Normal Human Lung Macrophages

Contact Info

Product

Resources

About