The relationship of the renin-angiotensin-aldosterone system to plasma gonadotropin, prolactin, and ovarian steroid patterns during the menstrual cycle

Kaulhausen, H.; Leyendecker, G.; Benker, G.; Breuer, H.

doi:10.1007/bf00667201

Cited by 15 publications

(3 citation statements)

References 29 publications

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“…A progressive increase in plasma REN concentrations before ovulation also happens in women (Kaulhausen et al 1978;Loret de Mola et al 1999), rats (De Vito et al 1989), and baboons (Harewood et al 1996). It has been attributed to the release of LH or to the stimulating effect of human chorionic gonadotropin (hCG).…”

Section: Discussionmentioning

confidence: 99%

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Satué¹,

Montesinos²,

Munos³

2017

CZECH J ANIM SCI

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Satué K., Montesinos P., Muños A. (2017): Activation of the renin-angiotensin-aldosterone system in mares around ovulation. Czech J. Anim. Sci., 62,[259][260][261][262][263][264][265][266][267] Many physiological events occurring during the estrous cycle, including folliculogenesis, oocyte maturation, ovulation, follicular atresia, corpus luteum development, luteolysis, steroidogenesis, and angiogenesis are associated with an increased expression of the renin-angiotensin-aldosterone system (RAAS) in uterus and ovarian follicles. This enhanced expression leads to a rise in plasma concentrations of these hormones in women and laboratory animals, and the same might happen in the mare. This study aims to assess if an activation of the RAAS occurs in mares around ovulation and if this activation is related to the diameter of the predominant follicle (DPF), packed cell volume (PCV), and electrolyte concentrations. Twenty-five healthy Spanish Purebred mares were sampled during the five days before ovulation, the day of ovulation, and the first five days after ovulation. Renin (REN) concentrations increased progressively during the five days before ovulation, achieving the highest values on the day of ovulation. Angiotensin (ANG) concentrations showed a sharp decrease after ovulation, with the lowest values the fifth day after it. Aldosterone (ALD) concentrations increased progressively, from the fifth day before ovulation until the fifth day after ovulation. The highest PCV values were found on the day of ovulation. There were no relevant correlations between the RAAS components and electrolytes concentrations. Before ovulation, there was a positive relationship between REN and ALD (r = 0.760) and after ovulation, a negative correlation between ANG and ALD (r = -0.660). The DPF was correlated with REN (r = 0.740) and with ALD (r = 0.800) concentrations. Ovulation in the mare is associated with high plasma REN concentrations, and therefore, with an activation of the RAAS. In addition, after ovulation, the sharp decrease in plasma REN and ANG concentrations might be a reflex of the modulation of the previously activated RAAS, although plasma ALD concentrations increased during this period.

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Section: Discussionmentioning

confidence: 99%

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Satué¹,

Montesinos²,

Munos³

2017

CZECH J ANIM SCI

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“…The origin of the preovulatory aldosterone peak is unknown, but it has been speculated that the increase in E2 could exert a stimulatory effect on angiotensinogen in the liver, and this, in turn, increases PRA and aldosterone [52,53,55]. Other researches, on the contrary, failed to find any relationship between angiotensinogen, PRA, and aldosterone in physiological cycles [11,17,19,57], ruling out some type of significant influence of endogenous E2 on PRA and AUE during the periovulatory period [9,10,41]. Despite these contradictory results, the hypothesis that the increase in angiotensinogen is the cause of PRA and aldosterone peaks is still commonly accepted.…”

Section: Changes In the Renin-angiotensin-aldosterone System During Tmentioning

confidence: 99%

Scientific Evidences Supporting the Activation of the Renin-Angiotensin-Aldosterone System during Estral Cycle and Pregnancy in Mares

Satué¹,

Muñoz²

2020

Selected Chapters From the Renin-Angiotensin System

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In women and laboratory animals, local and circulating components of the renin-angiotensin-aldosterone system (RAAS) are related to specific reproductive functions that occur during the estrous cycle, such as folliculogenesis, ovulation, corpus luteum development, and steroidogenesis. Also, in pregnant females of these species, maternal cardiovascular and renal systems undergo intense modifications, with the aim of matching the increased energy requirements of the fetus and fetoplacental unit. Some of these changes can be the origin, and others the consequence of a new endocrine environment. The fetus and the placenta induce endocrine changes, with modifications in the protein, lipid, carbohydrate, and mineral metabolism, together with simultaneous cardiovascular changes derived from the uterine growth and its content. The participation of RAAS during this period is of vital importance to regulate these cardiovascular, hemodynamic, hematological, and metabolic adjustments imposed by pregnancy because they will have a direct influence on the correct development and viability of the fetus. In mares, our research team has been investigating the changes of RAAS in mares during the estral cycle and during pregnancy, and these results are presented in the current chapter, comparing with the data previously reported for women and laboratory animals.

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“…1) during the preovulatory phase of the men¬ strual cycle, peaks of renin and aldosterone have been demonstrated which can not be explained by changes in progesterone or 17ct-hydroxyprogesterone concentrations (Kaulhausen et al 1978),…”

mentioning

confidence: 97%

Evidence for two independent effects of oestradiol benzoate on the renin-angiotensin-aldosterone system

Kaulhausen¹,

Weyand²

1982

Acta Endocrinologica

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Abstract. Plasma renin concentrations (PRC), plasma renin substrate concentration (PRS), plasma aldosterone and cortisol concentrations as well as plama renin activity (PRA) were measured in ovariectomized subjects after im administration of 10 mg oestradiol benzoate (EB). The esterified oestrogen exerts two independent effects on the renin-angiotensin-aldosterone system. 1) 48 h after EB administration, PRS was significantly increased. Similar results were obtained for total plasma cortisol, reflecting transcortin concentration. In both cases, the increase was quantitatively related to the basal concentrations. These observations are consistent with the well known oestrogen-induced protein synthesis in the liver. 2) The elevation of PRC preceded that of PRS and was already significant 11 h after EB injection. The early rise in plasma renin activity was essentially caused by the increase in PRC, whereas an influence of the activated substrate synthesis was found later, between the 2nd and the 4th day post injection. The time course of plasma aldosterone concentration correlated well with the increased PRA. The results provide evidence that EB has two different effects on the renin-aldosterone axis: an early one by elevating renin release and a delayed one by increasing renin substrate synthesis. Whereas the second mechanism can clearly be localized in the liver, extrarenal as well as direct renal effects of EB may be responsible for the renin stimulation.

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The relationship of the renin-angiotensin-aldosterone system to plasma gonadotropin, prolactin, and ovarian steroid patterns during the menstrual cycle

Cited by 15 publications

References 29 publications

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Scientific Evidences Supporting the Activation of the Renin-Angiotensin-Aldosterone System during Estral Cycle and Pregnancy in Mares

Evidence for two independent effects of oestradiol benzoate on the renin-angiotensin-aldosterone system

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