The Relationship of the Male Preputial Gland to the Acceleration of Oestrus in the Laboratory Mouse

Chipman, Robert K.; Albrecht, Eugene D.

doi:10.1530/jrf.0.0380091

Cited by 34 publications

(6 citation statements)

References 8 publications

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“…Sexual behavior could be affected in Mab21l1 -/-mice for either of the following reasons. First, the preputial gland in male mice has been shown to contribute to pheromonal function: generating chemosignals that attract females and accelerating oestrus (Bronson and Caroom, 1971;Chipman and Albrecht, 1974). Second, the localization of Mab21l1 transcripts within the CNS is consistent with studies that link reproductive behavior to specific regions of the brain, collectively known as the vomeronasal system (VNS) (Segovia Mab21l1 in lens placode development and Guillamon, 1993).…”

Section: Male and Female Sterility In Mab21l1 Mutantsmentioning

confidence: 65%

Cell-autonomous involvement ofMab21l1is essential for lens placode development

et al. 2003

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The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologs, Mab21l1 andMab21l2, have been identified in many species. We describe the generation of Mab21l1-deficient mice with defects in eye and preputial gland formation. The mutant mouse eye has a rudimentary lens resulting from insufficient invagination of the lens placode caused by deficient proliferation. Chimera analyses suggest that the lens placode is affected in a cell-autonomous manner, although Mab21l1 is expressed in both the lens placode and the optic vesicle. The defects in lens placode development correlate with delayed and insufficient expression ofFoxe3, which is also required for lens development, while Maf,Sox2, Six3 and PAX6 levels are not significantly affected. Significant reduction of Mab21l1 expression in the optic vesicle and overlying surface ectoderm in Sey homozygotes indicates that Mab21l1expression in the developing eye is dependent upon the functions ofPax6 gene products. We conclude that Mab21l1 expression dependent on PAX6 is essential for lens placode growth and for formation of the lens vesicle; lack of Mab21l1 expression causes reduced expression of Foxe3 in a cell-autonomous manner.

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Section: Male and Female Sterility In Mab21l1 Mutantsmentioning

confidence: 65%

Cell-autonomous involvement ofMab21l1is essential for lens placode development

et al. 2003

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“…Whether or not the farnesene^MUP complex is assembled already in the preputial secretion or in the voided urine is currently unknown. Importantly, the fact that both the farnesenes and the bladder-originated volatile ligands are active in puberty acceleration could help resolve yet another long-term controversy in the literature pertaining to a source of the oestrus-inducing chemosignal (Chipman & Albrecht 1974;). We have previously found that a mixture of BT with DB in water (Jemiolo et al 1986) and a mixture of a-and b-farnesene (Ma et al 1999) are both active in oestrus induction.…”

Section: Discussionmentioning

confidence: 99%

Positive identification of the puberty-accelerating pheromone of the house mouse: the volatile ligands associating with the major urinary protein

Novotný

Wiesler

et al. 1999

Proc. R. Soc. Lond. B

208

133

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Five structurally diverse small ligands, all binding to the major urinary protein (MUP) of the male house mouse, show individually puberty-accelerating pheromonal activity in the recipient females. A recombinant MUP (identical structurally to the natural protein) has shown no biological activity. While four of these ligands were previously implicated in oestrus synchronization (Whitten e¡ect), the same chemosignals now appear responsible for both sexual maturation and cycling in adult females.

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“…C hipman and Albrecht [1974] have suggested that the secretion can accel erate the estrous cycle in the mouse.…”

Section: Discussionmentioning

confidence: 99%

Effect of testosterone propionate on the ultrastructure of the preputial gland in the rat

Nickerson¹,

Freeman²,

Brownie³

1976

Cells Tissues Organs

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Testosterone propionate accelerates the maturation of acinar cells in the preputial gland of female rats. The weight of the preputial gland was increased significantly and the gland contained a large amount of secretory material. Various stages of maturation of acinar cells were observed. In an early stage, cells contained predominantly rough endoplasmic reticulum. In a second stage, lipid accumulated in association with focal areas of smooth endoplasmic reticulum. Membrane-bound dense bodies similar to lysosomes and secondary lysosomes predominated in a late stage. In the final stage, acini fused with a duct, thereby liberating the cells into the ductal lumen. Cell structure then became unrecognizable.

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The Relationship of the Male Preputial Gland to the Acceleration of Oestrus in the Laboratory Mouse

Cited by 34 publications

References 8 publications

Cell-autonomous involvement ofMab21l1is essential for lens placode development

Cell-autonomous involvement ofMab21l1is essential for lens placode development

Positive identification of the puberty-accelerating pheromone of the house mouse: the volatile ligands associating with the major urinary protein

Effect of testosterone propionate on the ultrastructure of the preputial gland in the rat

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