The relationship of the geriatric nutritional risk index to mortality and length of stay in elderly patients with acute respiratory failure: A retrospective cohort study

Shi, Xiawei; Shen, Yueqian; Yang, Jia; Du, Wurong; Junchao, Yang

doi:10.1016/j.hrtlng.2021.07.012

Cited by 11 publications

(12 citation statements)

References 63 publications

(50 reference statements)

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“…The GNRI was first proposed by Bouillanne et al in 2005 10 and validated as a reliable prognostic nutritional index for elderly patients with various clinical conditions, such as those admitted to a geriatric rehabilitation care unit 10 , with acute ischemic stroke 38 , heart failure 39 , respiratory failure 40 , after emergency surgeries 41 . Further studies in oncology showed that GNRI may also be applied as an effective prognostic index in patients with various malignancies, which was also not limited to elderly patients 42 .…”

Section: Discussionmentioning

confidence: 99%

Geriatric Nutritional Risk Index as a Prognostic Factor of Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Yang

Liu

et al. 2022

Horm Metab Res

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Geriatric nutritional risk index (GNRI), a newly developed indicator of nutritional status retrieved by serum albumin concentration and ideal body weight, has been suggested as a prognostic factor for various malignancies. The aim of the study was to summarize the prognostic role of GNRI for patients with non-small cell lung cancer (NSCLC) in a meta-analysis. Cohort studies evaluating the relationship between GNRI at baseline and survival OF NSCLC were retrieved by search of PubMed, Embase, and Web of Science databases from inception to January 12, 2022. A conservative random-effect model incorporating the possible influence of between-study heterogeneity was used to pool the results. Eleven cohorts including 2865 patients with NSCLC were included. Compared to those with higher GNRI, NSCLC patients with lower GNRI were associated with poorer overall survival [OS, hazard ratio (HR): 2.39, 95% CI: 1.97–2.91, p<0.001; I2=29%), progression-free survival (HR: 1.94, 95% CI: 1.52–2.47, p<0.001; I2=29%), and cancer-specific survival (HR: 2.59, 95% CI: 1.55–4.35, p<0.001; I2=0%). Subgroup analyses showed that the significant association between lower GNRI and worse OS in patients with NSCLC was not affected by study characteristics including study location, design, cancer stage, treatment, or follow-up durations (p for subgroup effects all<0.001). In conclusion, a lower GNRI in patients with NSCLC may be a predictor of poor survival. Nutritional status indicated by GNRI may be important for the prognostic prediction of patients with NSCLC.

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Section: Discussionmentioning

confidence: 99%

Geriatric Nutritional Risk Index as a Prognostic Factor of Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Yang

Liu

et al. 2022

Horm Metab Res

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“…Other studies used nutrition screening tools that mainly relied on biochemical indices such as serum albumin (i.e. controlling nutritional status index [CONUT], 12 prognostic nutritional index [PNI], 12 geriatric nutritional risk index [GNRI], 10,11,14 and Onodera's prognostic nutritional index [OPNI]). 10 They reported 43.9-76.3% of older ICU patients had biochemical derangements.…”

Section: Methodsmentioning

confidence: 99%

Nutrition therapy in the older critically ill patients: A scoping review

Lee

Loh

Lew

et al. 2022

Ann Acad Med Singap

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Introduction: There is a lack of guidelines or formal systematic synthesis of evidence for nutrition therapy in older critically ill patients. This study is a scoping review to explore the state of evidence in this population. Method: MEDLINE and Embase were searched from inception until 9 February 2022 for studies that enrolled critically ill patients aged ≥60 years and investigated any area of nutrition therapy. No language or study design restrictions were applied. Results: Thirty-two studies (5 randomised controlled trials) with 6 topics were identified: (1) nutrition screening and assessments, (2) muscle mass assessment, (3) route or timing of nutrition therapy, (4) determination of energy and protein requirements, (5) energy and protein intake, and (6) pharmaconutrition. Topics (1), (3) and (6) had similar findings among general adult intensive care unit (ICU) patients. Skeletal muscle mass at ICU admission was significantly lower in older versus young patients. Among older ICU patients, low muscularity at ICU admission increased the risk of adverse outcomes. Predicted energy requirements using weight-based equations significantly deviated from indirect calorimetry measurements in older vs younger patients. Older ICU patients required higher protein intake (>1.5g/kg/day) than younger patients to achieve nitrogen balance. However, at similar protein intake, older patients had a higher risk of azotaemia. Conclusion: Based on limited evidence, assessment of muscle mass, indirect calorimetry and careful monitoring of urea level may be important to guide nutrition therapy in older ICU patients. Other nutrition recommendations for general ICU patients may be used for older patients with sound clinical discretion. Keywords: Critical care nutrition, geriatric patients, intensive care medicine, older adults, scoping review

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“…Recently, the geriatric nutritional risk index (GNRI), a newly developed indicator of nutritional status retrieved by serum albumin concentration and ratio between actual and ideal body weight (21), has been associated with sarcopenia and frailty, two recognized risk factors of poor prognosis in older people (22,23). The GNRI was firstly developed by Bouillanne et al in 2005 (21) and validated as a reliable prognostic nutritional index for elderly patients with various clinical conditions, such as those admitted to a geriatric rehabilitation care unit (21), with acute ischemic stroke (24), heart failure (25), respiratory failure (26), after emergency surgeries (27). Compared with the above nutritional assessment parameters, such as MNA and NRS-2002, the GNRI is a simple, objective, and less time-consuming tool, which could also be readily determined from routinely collected laboratory data.…”

Section: Introductionmentioning

confidence: 99%

“…The GNRI was firstly developed by Bouillanne et al. in 2005 ( 21 ) and validated as a reliable prognostic nutritional index for elderly patients with various clinical conditions, such as those admitted to a geriatric rehabilitation care unit ( 21 ), with acute ischemic stroke ( 24 ), heart failure ( 25 ), respiratory failure ( 26 ), after emergency surgeries ( 27 ). Compared with the above nutritional assessment parameters, such as MNA and NRS-2002, the GNRI is a simple, objective, and less time-consuming tool, which could also be readily determined from routinely collected laboratory data.…”

Section: Introductionmentioning

confidence: 99%

Geriatric Nutritional Risk Index and Survival of Patients With Colorectal Cancer: A Meta-Analysis

et al. 2022

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BackgroundGeriatric nutritional risk index (GNRI) is an indicator of nutritional status derived by serum albumin level and ideal body weight, which has been proposed as a predictor of prognosis for elderly population with various clinical conditions. The objective of the meta-analysis was to comprehensively evaluate the association between baseline GNRI and survival of patients with colorectal cancer (CRC).MethodsCohort studies were identified by search of PubMed, Embase, and Web of Science databases from inception to January 05, 2022 according to the aim of the meta-analysis. A random-effect model incorporating the potential between-study heterogeneity was adopted to pool the results.ResultsNine studies including 3658 patients with CRC contributed to the meta-analysis. Results showed that CRC patients with lower GNRI at baseline had worse overall survival (OS, hazard ratio [HR] 2.39, 95% confidence interval [CI] 1.78-3.23, p<0.001; I2 = 60%) and progression-free survival (PFS, HR 1.77, 95% CI 1.38-2.26, p<0.001; I2 = 33%). The results were consistent in sensitivity analyses limited to elderly patients (HR for OS 2.25, p<0.001; HR for PFS 1.65, p=0.003). Subgroup analyses showed consistent results in patents with different cancer stages, and in studies with median follow-up < and ≥ 5 years (p for subgroup effects all < 0.05).ConclusionA lower GNRI at baseline may be independent associated with poor survival outcomes of patients with CRC. Evaluating the nutritional status using GNRI may be important for risk stratification of patients with CRC.

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The relationship of the geriatric nutritional risk index to mortality and length of stay in elderly patients with acute respiratory failure: A retrospective cohort study

Cited by 11 publications

References 63 publications

Geriatric Nutritional Risk Index as a Prognostic Factor of Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Geriatric Nutritional Risk Index as a Prognostic Factor of Patients with Non-Small Cell Lung Cancer: A Meta-Analysis

Nutrition therapy in the older critically ill patients: A scoping review

Geriatric Nutritional Risk Index and Survival of Patients With Colorectal Cancer: A Meta-Analysis

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