The Relationship of the Antigenic Determinants Expressed by Rat Lymphoid Cells to Their Participation in Graft‐versus‐host Reactions

McCullagh, Peter

doi:10.1038/icb.1985.66

Cited by 1 publication

(2 citation statements)

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“…The relationship of the target antigens examined in these experiments to MHS determinants can be established only by demonstrating correlation between the presence of an antigen and the capacity of cells expressing it to engage in MHS-regulated activities. The accompanying paper reports relationships between possession of target antigens and the ability of lymphocytesto initiate and respond in graft-versus-host reactions which suggest that these antigens are closely related to MHS determinants (McCullagh, 1985).…”

Section: Discussionmentioning

confidence: 99%

“…Class 1 major histocompatibility system (MHS) antigens have generally been assumed to be uniformly expressed on the lymphocytes of any individual despite reports suggesting that the level of expression of MHS determinants on Fl hybrids' lymphocytes may be less than on parental strain cells (Galfre et al, 1977). This and the succeeding paper (McCullagh, 1985) present data which suggest that MHS determinants are not expressed equally on all of a rat's lymphocytes.…”

Section: Introductionmentioning

confidence: 87%

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Heterogeneous Expression of Antigenic Determinants by Rat Lymphocytes

McCullagh¹

1985

Aust J Exp Biol Med

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Summary. Exposure of lymphocytes from F2 hybrid and backcross rats of the PVG and DA strains to inter-parental strain alloantisera and complement frequently and unexpectedly revealed incomplete susceptibility within a population of cells. This heterogeneity did not appear to result from variable susceptibility to cytotoxic mechanisms. A more likely explanation was that variation occurred in the expression of the target determinants within the lymphocyte population. A similar heterogeneity was also demonstrable in populations of lymphocytes from rats of the inbred DA strain, provided appropriate alloantisera were used. Antisera raised in PVG rats against individual (PVGxF,) backcross rats frequently effected intermediate levels of DA cell destruction in the presence of complement, although exposure of DA lymphocytes to PVG anti-DA serum plus complement resulted in their uniform destruction. The nature of the target antigens that were subject to variable expression was not established, but it seemed likely that they were related to histocompatibility determinants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%