The relationship of systemic right ventricular function to ECG parameters and NT-proBNP levels in adults with transposition of the great arteries late after Senning or Mustard surgery

Plymen, Carla M.; Hughes, Marina; Picaut, Nathalie; Panoulas, Vasileios F.; MacDonald, Simon T.; Cullen, Seamus; Deanfield, John; Walker, Fiona; Taylor, Andrew M.; Lambiase, Pier D.; Bolger, Aidan P.

doi:10.1136/hrt.2010.198648

Cited by 47 publications

(27 citation statements)

References 29 publications

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“…A similar association was described previously in adults with congestive heart failure from acquired heart disease, 29,30 as well as in a general group of adults with CHD 22 and, most recently, in patients with TGA. 31, 32 Moreover, the present data are also in agreement with the results from a smaller group of younger patients after ASO or with congenitally corrected TGA. In that study, asymptomatic patients had normal BNP, while BNP increased after deterioration of clinical status or with decreasing exercise capacity.…”

Section: Study Limitationssupporting

confidence: 82%

Prognostic Value of Plasma B-Type Natriuretic Peptide in the Long-Term Follow-up of Patients With Transposition of the Great Arteries With Morphologic Right Systemic Ventricle After Atrial Switch Operation

Haberger

Hauser

Braun

et al. 2015

Circ J

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Section: Study Limitationssupporting

confidence: 82%

Prognostic Value of Plasma B-Type Natriuretic Peptide in the Long-Term Follow-up of Patients With Transposition of the Great Arteries With Morphologic Right Systemic Ventricle After Atrial Switch Operation

Haberger

Hauser

Braun

et al. 2015

Circ J

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“…A significant negative correlation between BNP levels and RV function measured by either CMR or echocardiography was found in 5 of 8 studies (correlation coefficients ranging from r ϭ Ϫ0.42 to r ϭ Ϫ0.54) ( Table 2) (24,25,29,33,34). Secondly, a weaker but still significant positive correlation between BNP and end-diastolic RV volume was observed (24,25,29,33). Furthermore, a positive correlation was found between the severity of tricuspid valve regurgitation (TR) and BNP (27,35).…”

Section: Resultsmentioning

confidence: 81%

“…In addition, an association between BNP levels and NYHA functional class was reported in 3 studies (Table 2) (27,29,33). A significant negative correlation between BNP levels and RV function measured by either CMR or echocardiography was found in 5 of 8 studies (correlation coefficients ranging from r ϭ Ϫ0.42 to r ϭ Ϫ0.54) ( Table 2) (24,25,29,33,34). Secondly, a weaker but still significant positive correlation between BNP and end-diastolic RV volume was observed (24,25,29,33).…”

Section: Resultsmentioning

confidence: 96%

The Usefulness of Brain Natriuretic Peptide in Complex Congenital Heart Disease

Eindhoven¹,

Bosch²,

Jansen³

et al. 2012

Journal of the American College of Cardiology

148

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Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are well-established markers for heart failure in the general population. However, the value of BNP as a diagnostic and prognostic marker for patients with structural congenital heart disease (CHD) is still unclear. Therefore, the purpose of this study was to evaluate the clinical utility of BNP in patients with CHD. We executed a PubMed literature search and included 49 articles that focused on complex congenital heart defects such as tetralogy of Fallot, systemic right ventricle, and univentricular hearts. Data on BNP measurements and cardiac function parameters were extracted. In all patients after correction for tetralogy of Fallot, BNP levels were elevated and correlated significantly with right ventricular end-diastolic dimensions and severity of pulmonary valve regurgitation. Patients with a systemic right ventricle had elevated BNP levels, and positive correlations between BNP and right ventricular function were seen. In patients with a univentricular heart, elevated BNP levels were observed before completion of the Fontan circulation or when patients were symptomatic; a clear association between BNP and New York Heart Association functional class was demonstrated. In conclusion, this review shows an overall increase in BNP values in complex CHD, although differences between types of congenital heart anomaly are present. As BNP values differ widely, conclusions for individual patients should be drawn with caution. Further investigation with sequential BNP measurement in a large, prospective study is warranted to elucidate the prognostic value of BNP assessment in patients with CHD.

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“…20 Natriuretic peptides and their relations to clinical and echocardiographic parameters have been recently studied in different particular congenital heart diseases. 16,[18][19][20][21][22][23][24][25][26][27][28] The neurohormonal activation in ACHD may persist many years after repair and it was found even in asymptomatic patients. 13,29 Residual lesions after repair may become more important In conclusion, our results show that NT-proBNP can be an extremely useful, quick and simple prognostic marker for identification of patients in high risk.…”

Section: Discussionmentioning

confidence: 98%

Usefulness of N-Terminal Pro-Brain Natriuretic Peptide to Predict Mortality in Adults With Congenital Heart Disease

Popelová

Kotaška

Tomková

et al. 2015

The American Journal of Cardiology

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Natriuretic peptides are often elevated in congenital heart disease (CHD); however, the clinical impact on mortality is unclear. The aim of our study was to evaluate the prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the prediction of all-cause mortality in adults with different CHD. In this prospective longitudinal mortality study, we evaluated NT-proBNP in 1,242 blood samples from 646 outpatient adults with stable CHD (mean age 35 ± 12 years; 345 women). Patients were followed up for 6 ± 3 (1 to 10) years. The mortality rate was 5% (35 patients, mean age 40 ± 14 years, 17 women). Median NT-proBNP (pg/ml) was 220 in the whole cohort, 203 in survivors, and 1,548 in deceased patients. The best discrimination value for mortality prediction was 630 pg/ml with 74% sensitivity and 84% specificity. During the follow-up, the survival rate was 65% for those with median NT-proBNP ≥630 pg/ml and 94% for NT-proBNP <630 pg/ml; p <0.0001. There was only 1% mortality among 388 patients with at least 1 NT-proBNP value ≤220 pg/ml compared with 41% mortality among 54 patients with at least 1 NT-proBNP value >1,548 pg/ml. Even the first (baseline) measurements of NT-proBNP were strongly associated with a high risk of death (log10 NT-proBNP had hazard ratio 7, p <0.0001). In conclusion, NT-proBNP assessment is a useful and simple tool for the prediction of mortality in long-term follow-up of adults with CHD.

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The relationship of systemic right ventricular function to ECG parameters and NT-proBNP levels in adults with transposition of the great arteries late after Senning or Mustard surgery

Cited by 47 publications

References 29 publications

Prognostic Value of Plasma B-Type Natriuretic Peptide in the Long-Term Follow-up of Patients With Transposition of the Great Arteries With Morphologic Right Systemic Ventricle After Atrial Switch Operation

Prognostic Value of Plasma B-Type Natriuretic Peptide in the Long-Term Follow-up of Patients With Transposition of the Great Arteries With Morphologic Right Systemic Ventricle After Atrial Switch Operation

The Usefulness of Brain Natriuretic Peptide in Complex Congenital Heart Disease

Usefulness of N-Terminal Pro-Brain Natriuretic Peptide to Predict Mortality in Adults With Congenital Heart Disease

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