The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale

Norman, Ross; Malla, Ashok; McLean, Terry; Voruganti, Lakshmi P.; Cortese, Leonard; McIntosh, Elizabeth; Cheng, Stephen; Rickwood, Ann

doi:10.1034/j.1600-0447.2000.102004303.x

Cited by 202 publications

(132 citation statements)

References 13 publications

(21 reference statements)

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“…Lower everyday functioning capacity and greater severity of positive, negative, and depressive symptoms have been associated with worse QOL (Hofer et al, 2005b;Norman et al, 2000;Palmer et al, 2002;Sciolla et al, 2003;Corrigan & Buican, 1995;Jin et al, 2001;Ruggeri et al, 2005;Twamley et al, 2002). Although such psychiatric symptoms have been associated with subjective measures of QOL (Hofer et al, 2005b;Ruggeri et al, 2005;Norman et al, 2000;Corrigan and Buican, 1995), symptom reductions alone often do not result in meaningful improvements in QOL because other problems remain (e.g., difficulty with everyday functioning, lack of social contacts, unemployment, and stigmatization).…”

Section: Predictors Of Subjective Qolmentioning

confidence: 99%

“…Although such psychiatric symptoms have been associated with subjective measures of QOL (Hofer et al, 2005b;Ruggeri et al, 2005;Norman et al, 2000;Corrigan and Buican, 1995), symptom reductions alone often do not result in meaningful improvements in QOL because other problems remain (e.g., difficulty with everyday functioning, lack of social contacts, unemployment, and stigmatization).…”

Section: Predictors Of Subjective Qolmentioning

confidence: 99%

“…Poorer cognitive performance and self-reported functional status (e.g., unmarried, lower social functioning, smaller social support network) are correlated with lower subjective QOL (Corrigan and Buican, 1995;Norman et al, 2000;Lehman et al, 1983a). On the other hand, better cognitive abilities may translate into better insight, more depression, and lower subjective well-being.…”

Section: Predictors Of Subjective Qolmentioning

confidence: 99%

“…However, the predictors of QOL in schizophrenia are not well understood. Although no universal definition of QOL exists, the construct usually includes subjective well-being and objective mental and physical functioning indicators (Lehman, 1983b;Norman et al, 2000;Bow-Thomas et al, 1999;Voruganti et al, 1998;Russo et al, 1997;Lambert and Naber, 2004). Subjective QOL focuses on life satisfaction, whereas "objective" QOL focuses on participation in activities and interpersonal relationships.…”

Section: Introductionmentioning

confidence: 99%

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Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

191

138

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Objective-Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually defined as participation in activities and relationships). We examined separately the clinical, functional, and cognitive predictors of subjective and objective QOL in outpatients with schizophrenia. We hypothesized that better subjective QOL would be associated with less severe negative and depressive symptoms, better objective QOL, and greater everyday functioning capacity, and that better objective QOL would be associated with less severe negative and depressive symptoms, better cognitive performance, and greater functional capacity.Method-Participants included 88 outpatients with schizophrenia or schizoaffective disorder who completed a comprehensive series of assessments, including measures of positive, negative, and depressive symptoms; performance-based functional skills; a neuropsychological battery; and an interview measure of subjective and objective QOL.Results-In the context of multiple predictor variables, more severe depressive symptoms and better neuropsychological functioning were independent predictors of worse subjective QOL. More severe negative symptoms predicted worse objective QOL. Functional capacity variables were not associated with subjective or objective QOL.Conclusion-Treatments to improve QOL in schizophrenia should focus on negative symptoms and depressive symptoms.

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Section: Predictors Of Subjective Qolmentioning

confidence: 99%

Section: Predictors Of Subjective Qolmentioning

confidence: 99%

Section: Predictors Of Subjective Qolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

191

138

View full text Add to dashboard Cite

show abstract

“…In the past years, QOL has become an important outcome measure for those patients, although the associations between predictors and QOL are rather unclear. Several cross-sectional studies have investigated the relationship between the subjective QOL of people with severe mental disorders and socio-demographic and clinical characteristics (Norman et al, 2000;Fitzgerald et al, 2001;Becchi et al, 2004;Caron et al, 2005aCaron et al, , 2005bHofer et al, 2006;Narvaez et al, 2008;Hsiao et al, 2012;Fujimaki et al, 2012). In addition, some studies have explored the mediating role of self-related factors, such as lower self-esteem, lack of perceived social support and low self-efficacy in QOL appraisal (Bechdolf et al, 2003;Ritsner et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The effect of service satisfaction and spiritual well-being on the quality of life of patients with schizophrenia

Lanfredi

Candini

Buizza

et al. 2014

Psychiatry Research

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a b s t r a c tQuality of life (QOL) has been considered an important outcome measure in psychiatric research and determinants of QOL have been widely investigated. We aimed at detecting predictors of QOL at baseline and at testing the longitudinal interrelations of the baseline predictors with QOL scores at a 1-year follow-up in a sample of patients living in Residential Facilities (RFs). Logistic regression models were adopted to evaluate the association between WHOQoL-Bref scores and potential determinants of QOL. In addition, all variables significantly associated with QOL domains in the final logistic regression model were included by using the Structural Equation Modeling (SEM). We included 139 patients with a diagnosis of schizophrenia spectrum. In the final logistic regression model level of activity, social support, age, service satisfaction, spiritual well-being and symptoms' severity were identified as predictors of QOL scores at baseline. Longitudinal analyses carried out by SEM showed that 40% of QOL follow-up variability was explained by QOL at baseline, and significant indirect effects toward QOL at follow-up were found for satisfaction with services and for social support. Rehabilitation plans for people with schizophrenia living in RFs should also consider mediators of change in subjective QOL such as satisfaction with mental health services.

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Quetiapine has a direct effect on the negative symptoms of schizophrenia

Tandon

2004

Human Psychopharmacology

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Second-generation 'atypical' antipsychotics appear to be more effective than first-generation 'typical' antipsychotics in improving negative symptoms in schizophrenia; it is unclear, however, if this greater improvement represents a direct beneficial effect or is mediated indirectly by an antidepressant effect or the absence of extrapyramidal symptoms (EPS). To address this issue with reference to quetiapine ('Seroquel'), data were evaluated from four randomized, controlled clinical studies involving 1106 patients employing a path analysis model. The total effect of quetiapine on negative symptoms was measured using the Scale for Assessment of Negative Symptoms (SANS) total score. Indirect effects on negative symptoms via positive, depressive and EPS were assessed using appropriate instruments. Effect sizes were calculated by path analysis for the difference between treatment groups in change from baseline to endpoint in SANS total score. Analysis confirmed that quetiapine produced a greater overall improvement in negative symptoms than placebo (effect size 1.96); this was explained by a significant direct effect (p = 0.001; 44.2% of total improvement), and a secondary effect of improved positive symptoms (p < 0.001; 47.5% of total improvement), but was not a consequence of changes in depressive symptoms or EPS. Within the constraints of the path analysis methodology, these results indicate that quetiapine has a substantial direct effect on improving the negative symptoms of schizophrenia.

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The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale

Abstract: The results highlight the importance of recognizing the complex nature of the concept of quality of life. They demonstrate that varying indices of quality of life are likely to have different predictors.

Cited by 202 publications

References 13 publications

Subjective and objective quality of life in schizophrenia

Subjective and objective quality of life in schizophrenia

The effect of service satisfaction and spiritual well-being on the quality of life of patients with schizophrenia

Quetiapine has a direct effect on the negative symptoms of schizophrenia

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