The relationship of survival to staging and grading of colorectal carcinoma: A prospective study of 503 cases

Newland, R. C.; Chapuis, Pierre; Pheils, Murray T.; Chir, M.; Macpherson, J. G.

doi:10.1002/1097-0142(19810315)47:6<1424::aid-cncr2820470630>3.0.co;2-o

Cited by 227 publications

(105 citation statements)

References 11 publications

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“…Poorly differentiated adenocarcinomas show invasive spreading histologically, and have a significantly poorer prognosis than well and moderately differentiated carcinomas (29). It has been reported that there was a significant correlation between the grade of histological differentiation and collagenolytic activity (30).…”

Section: Discussionmentioning

confidence: 99%

Expression of the ets-1 Proto-Oncogene in Human Colorectal Carcinoma

et al. 2001

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The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes involved in extracellular matrix remodeling and has been postulated to play a role in cell migration and tumor invasion. To elucidate the involvement of ets-1 in human colorectal carcinomas, we examined 41 cases of colorectal adenoma and 122 cases of colorectal carcinoma by immunohistochemistry and compared the degree of Ets-1 expression with the depth of carcinoma invasion. In adenomas, 12 of 41 cases (29.3%) showed immunopositivity for Ets-1. 12 of 27 cases (44.4%) of adenoma with high grade dysplasia showed immunopositivity for Ets-1. However, there was no positive case in low or moderate dysplasia of adenoma. In contrast, 103 of 122 cases (84.4%) of colorectal adenocarcinoma showed immunoreactivity for Ets-1 in the carcinoma cells themselves. We investigated the relationship between pathological features in colorectal carcinoma and Ets-1 immunoreactivity of the tumor cells. Among the 122 cases of invasive carcinomas, Ets-1 immunoreactivity was significantly correlated with the depth grading of tumor invasion (P < .0001), the presence of lymph node metastasis (P < .05), lymphatic invasion (P < .01) and venous invasion (P < .05). However, Ets-1 expression did not correlate with histological differentiation. In situ hybridization also confirmed the presence of ets-1 mRNA in colorectal carcinomas.

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Section: Discussionmentioning

confidence: 99%

Expression of the ets-1 Proto-Oncogene in Human Colorectal Carcinoma

et al. 2001

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“…Since 1971, clinical, operative, pathological and follow-up information on consecutive patients having a resection for rectal adenocarcinoma has been recorded prospectively in a computer database maintained at Concord Hospital 10 . Operations performed at Strathfield Private Hospital by members of the Concord colorectal unit have been included in the database since 1989.…”

Section: Methodsmentioning

confidence: 99%

Local recurrence after curative resection for rectal cancer is associated with anterior position of the tumour

Chan

Bokey

Chapuis

et al. 2006

Journal of British Surgery

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Background: Mobilization of rectal cancer can be difficult if the tumour is located anteriorly and may result in a higher incidence of local recurrence. The aim of this study was to determine whether local recurrence and survival following curative resection of rectal cancer were associated with the position of the tumour. Conclusion:Anterior position is an independent negative prognostic factor for both local recurrence and survival after curative resection of rectal cancer.

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“…In addition to being the result of a subjective evaluation, histologic grade is known to be strongly correlated with stage in colorectal cancer (Newland et al, 1981), and its independent prognostic value is questionable. Nevertheless, Chapuis et al, (1985) (Jass et al, 1986).…”

Section: Methodsmentioning

confidence: 99%

A regression analysis of prognostic factors after resection of Dukes' B and C carcinoma of the rectum and rectosigmoid. Does post-operative radiotherapy change the prognosis?

Bentzen¹,

Balslev²,

Pedersen³

et al. 1988

Br J Cancer

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Summary The prognostic value of several clinical and histopathological characteristics has been evaluated in patients with Dukes' B and C carcinoma of the rectum and the rectosigmoid. Data on 260 Dukes' B and 208 Dukes' C tumours entered into a prospective, randomized clinical trial of post-operative radiotherapy (5OGy given with 2Gy/fraction in an overall time of 7 weeks) were analyzed by means of the Cox proportional hazards model. The Dukes' stages B and C were analyzed in two separate multivariate analyses. In patients with Dukes' B tumours, a poor prognosis was associated with age above 60, perineural and venous invasion, tumour located 3.2 ng ml-1). In patients with Dukes' C tumours, perineural and venous invasion, tumour located 80 years, non-radical surgery, bedridden more than 50% of day 20-25 days after surgery, post-operative complications, previous cancer within 5 years and previous radiotherapy. A detailed description of material and methods has been published in Balslev et al. (1982Balslev et al. ( , 1986 Table I.

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The relationship of survival to staging and grading of colorectal carcinoma: A prospective study of 503 cases

Cited by 227 publications

References 11 publications

Expression of the ets-1 Proto-Oncogene in Human Colorectal Carcinoma

Expression of the ets-1 Proto-Oncogene in Human Colorectal Carcinoma

Local recurrence after curative resection for rectal cancer is associated with anterior position of the tumour

A regression analysis of prognostic factors after resection of Dukes' B and C carcinoma of the rectum and rectosigmoid. Does post-operative radiotherapy change the prognosis?

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