“…Modification of these aforementioned surface properties can be utilized to trigger specific molecular reactions controlling the adhesion, proliferation, or differentiation behavior of the cells (Ventre et al, 2012;Barthes et al, 2014;Huo et al, 2017;Raines et al, 2019). For instance, microscale textured surfaces can regulate the expression of integrin, which is a transmembrane receptor protein enabling cell adhesion on the metal surface (Raines et al, 2019), or hydrophilic surfaces (contact angle <90 • ) can promote enhanced cell response via promoting the deposition of focal adhesion proteins (Ponsonnet et al, 2003;Ranella et al, 2010;Bauer et al, 2013;Rupp et al, 2014;Cicek et al, 2019). Surface properties obviously play a crucial role in cell adhesion, and in order to reveal their cumulative effects, more thorough analyses are required.…”