The Relationship of Stress, Coping, Effect Expectancies and Craving

Grüsser, Sabine M.; Mörsen, Chantal; Wölfling, Klaus; Flor, Herta

doi:10.1159/000095813

Cited by 30 publications

(20 citation statements)

References 81 publications

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“…These findings are consistent with previous non-EMA studies conducted in laboratory (Cooney et al, 1997; and clinical settings (Grusser et al, 2007;Niaura et al, 2002). One study highlighted the time-varying effect of such intra-individual variables on craving (Shiyko et al, 2012).…”

Section: Discussionsupporting

confidence: 90%

Ecological momentary assessment in the investigation of craving and substance use in daily life: A systematic review

Serre

Fatséas

Swendsen

et al. 2015

Drug and Alcohol Dependence

307

222

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Section: Discussionsupporting

confidence: 90%

Ecological momentary assessment in the investigation of craving and substance use in daily life: A systematic review

Serre

Fatséas

Swendsen

et al. 2015

Drug and Alcohol Dependence

307

222

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“…While social drinkers report increases in cue-induced alcohol craving, findings on behavioral and physiological responses to cues in social drinkers are weak and quite mixed in the literature (Carter and Tiffany 1999b;Litt and Cooney 1999). In other evidence, severity of alcohol use has been shown to affect the magnitude of cue reactivity, compulsive alcohol seeking and stressrelated changes, including alcohol-related morbidity (Fox et al 2005;Grusser et al 2006Grusser et al , 2007Rosenberg and Mazzola 2007;Sinha 2008a, b;Yoon et al 2006). These data are consistent with large population-based studies indicating that with greater amounts of weekly or daily alcohol and drug use, there is greater risk of alcohol-related problems, addiction and chronic diseases (Dawson et al 2005;Rehm et al 2009;Room et al 2005).…”

Section: Studying Stress Cues and Alcohol Craving In The Laboratorysupporting

confidence: 69%

Modeling Relapse Situations in the Human Laboratory

Sinha

2011

Current Topics in Behavioral Neurosciences

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It is well known that alcoholism is a chronic relapsing illness. While stress significantly impacts alcoholism risk, there is also evidence that increasing levels of alcohol use affect peripheral and central stress and reward pathways thereby setting up a reciprocal relationship among the effects of alcohol consumption of the development, course of and recovery from alcoholism. This chapter reviews our efforts in assessing the integrity of stress pathways in alcoholism by examining whether altered responses of the stress pathways play a role in relapse risk. Using validated human laboratory procedures to model two of the most common situations that contribute to relapse risk, we review how such models in the laboratory can predict subsequent alcohol relapse. Empirical findings from human laboratory and brain imaging studies are reviewed to show that specific stress-related dysregulation accompanies the alcohol craving state in alcohol-dependent individuals, and such dysregulation along with increases in alcohol seeking are predictive of increased alcohol relapse risk. Finally, the significant implications of these findings for the development of novel treatment interventions that target stress processes and alcohol craving to improve alcoholism relapse outcomes are discussed.

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“…Moreover, these increases in negative emotion and anxiety were positively associated with sustained increases in alcohol craving only in alcoholics. Greater severity of alcohol abuse is associated with higher levels of distress and craving (Fox et al, 2005;Grusser et al, 2006Grusser et al, , 2007Yoon et al, 2006;Rosenberg and Mazzola, 2007). Preclinical studies and human positron emission tomography (PET) studies indicate chronic alcohol-related changes in mesolimbic dopamine transmission.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals

Sinha

Fox

Hong

et al. 2008

Neuropsychopharmacol

402

383

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Chronic alcohol abuse is associated with changes in stress and reward pathways that could alter vulnerability to emotional stress and alcohol craving. This study examines whether chronic alcohol abuse is associated with altered stress and alcohol craving responses. Treatment-engaged, 28-day abstinent alcohol-dependent individuals (ADs; 6F/22M), and social drinkers (SDs; 10F/18M) were exposed to a brief guided imagery of a personalized stressful, alcohol-related and neutral-relaxing situation, one imagery condition per session, presented in random order across 3 days. Alcohol craving, anxiety and emotion ratings, behavioral distress responses, heart rate, blood pressure, and salivary cortisol measures were assessed. Alcohol patients showed significantly elevated basal heart rate and salivary cortisol levels. Stress and alcohol cue exposure each produced a significantly enhanced and persistent craving state in alcohol patients that was marked by increased anxiety, negative emotion, systolic blood pressure responses, and, in the case of alcohol cue, behavioral distress responses, as compared to SDs. Blunted stress-induced cortisol responses were observed in the AD compared to the SD group. These data are the first to document that stress and cue exposure induce a persistent negative emotion-related alcohol craving state in abstinent alcoholics accompanied by dysregulated HPA and physiological arousal responses. As laboratory models of stress and negative mood-induced alcohol craving are predictive of relapse outcomes, one implication of the current data is that treatments targeting decreases in stress and alcohol cue-induced craving and regulation of stress responses could be of benefit in improving alcohol relapse outcomes.

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The Relationship of Stress, Coping, Effect Expectancies and Craving

Cited by 30 publications

References 81 publications

Ecological momentary assessment in the investigation of craving and substance use in daily life: A systematic review

Ecological momentary assessment in the investigation of craving and substance use in daily life: A systematic review

Modeling Relapse Situations in the Human Laboratory

Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals

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