The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome

Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.

doi:10.1016/j.metop.2021.100079

Cited by 10 publications

(11 citation statements)

References 23 publications

(21 reference statements)

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“…This proves that NRP-1 facilitates SARS-CoV-2 entry into host cells. Hence, cells and tissues enriched for NRP1 receptors exhibit enhanced viral infectivity risk [19,23,24]. Furthermore, some authors have suggested that NRP-1 is a cofactor of ACE2 and S protein binding, but without the presence of ACE2, SARS-CoV-2 has very low infectivity.…”

Section: Resultsmentioning

confidence: 99%

“…It should also be pointed out that SARS-CoV-2 does not infect cells that are NRP1-positive but ACE2-negative. On the contrary, SARS-CoV-2 infects ACE2positive cells in which NRP1 is knocked out [23,24]. Cantuti-Castelvetri et al generated lentiviral particles pseudotyped with S protein found in SARS-CoV-2.…”

Section: Resultsmentioning

confidence: 99%

“…It is well established that heart diseases, hypertension, or diabetes are high-risk conditions for severe COVID-19 disease. Therefore, taking into consideration the fact that polycystic ovary syndrome (PCOS) is very commonly associated with the metabolic syndrome, obesity and insulin resistance, and that enhanced activity of the renin-angiotensin system (RAS) is observed in the metabolic syndrome, Moin ASM et al suggest that PCOS may correlate with the circulating soluble NRP-1 (sNRP-1) level [24]. The authors examined the levels of NRP1, RAS-related proteins (ACE2, Renin, Angiotensinogen (AGT)) and VEGF in 146 PCOS patients and almost 100 controls using the Slow Off-rate Modified Aptamer-scan plasma protein measurement.…”

Section: Resultsmentioning

confidence: 99%

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The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review

Gudowska-Sawczuk

Mroczko

2021

JCM

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in 2019, is responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein that interacts with the host cell receptor is the Spike-1 (S1) subunit of the coronavirus. This subunit binds with receptors present on the host cell membrane. It has been identified from several studies that neuropilin-1 (NRP-1) is one of the co-receptors for SARS-CoV-2 entry. Therefore, in this review, we focus on the significance of NRP-1 in SARS-CoV-2 infection. MEDLINE/PubMed database was used for a search of available literature. In the current review, we report that NRP-1 plays many important functions, including angiogenesis, neuronal development, and the regulation of immune responses. Additionally, the presence of this glycoprotein on the host cell membrane significantly augments the infection and spread of SARS-CoV-2. Literature data suggest that NRP-1 facilitates entry of the virus into the central nervous system through the olfactory epithelium of the nasal cavity. Moreover, published findings show that interfering with VEGF-A/NRP-1 using NRP-1 inhibitors may produce an analgesic effect. The review describes an association between NRP-1, SARS-CoV-2 and, inter alia, pathological changes in the retina. Based on the published findings, we suggest that NRP-1 is a very important mediator implicated in, inter alia, neurological manifestations of SARS-CoV-2 infection. Additionally, it appears that the use of NRP-1 inhibitors is a promising therapeutic strategy for the treatment of SARS-CoV-2 infection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review

Gudowska-Sawczuk

Mroczko

2021

JCM

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“…More recently, however, a contrasting result was documented in PCOS women by Moin et al and indicated a lowered level of soluble NRP1 and increased level of RAS-related proteins in PCOS women, suggesting that lower plasma soluble NRP1 levels may indicate increased risk of COVID-19 disease. 49 Though the NRP1 isoform in this study was soluble NRP1, to reconcile these contrasting findings and to arrive at a conclusion, further extensive studies need to conductand demonstrate whether the up-regulation and participation of NRP-1 in COVID-19 could transform into long-term complication.…”

Section: Neuropilin 1 and Covid-19mentioning

confidence: 73%

“…The morbidity and mortality rate of COVID-19 is highest among elderly and those patients with comorbidities including obesity, diabetes, cardiovascular diseases, and polycystic ovarian syndrome (PCOS). 48 , 49 These high morbidity and mortality levels of COVID-19 in comorbid conditions are suggested to be associated with NRP1 expression level.…”

Section: Neuropilin 1 and Covid-19mentioning

confidence: 99%