The relationship of serum visfatin levels with clinical parameters, flow-mediated  dilation, and carotid intima-media thickness in patients with ankylosing spondylitis

Baykara, Rabia Aydoğan; Küçük, Adem; Tuzcu, Ayca; Tuzcu, Göksel; Cüre, Erkan; Uslu, Ali Uğur; Omma, Ahmet

doi:10.3906/sag-2012-351

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…There was a positive association between visfatin value with BADAI and BASFI in both cases groups. These findings partially agree with Baykara et al (17) who found positive relationship between visfatin and BADAI and BASFI in AS cases. Also, partially agree with Hulejová et al (16) who showed that visfatin levels had positive correlation with BADAI in nr-axSpA cases not in AS cases, which can be explained by the different study design.…”

Section: Figure (1): Visfatin Levels Among Studied Groupssupporting

confidence: 93%

“…Our study revealed that, there were increased visfatin levels among cases with AS and nr-axSpA when compared to control persons (p < 0.001). This partially agrees with few studies that demonstrated significantly greater serum visfatin levels in AS cases than in healthy control (HC) (15,16,17) . On the other hand, only one study had measured visfatin serum level in nr-axSpA patients and reported that there were nonsignificant higher visfatin levels in nr-axSpA patients than in HC (16) .…”

Section: Figure (1): Visfatin Levels Among Studied Groupssupporting

confidence: 92%

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Serum Visfatin levels in Ankylosing Spondylitis: Correlation with Disease Activity

2024

The Egyptian Journal of Hospital Medicine

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Background: Ankylosing spondylitis (AS) is a form of spondyloarthropathy (SPA) that is featured by sacroiliac joints (SIJ), axial skeleton, entheses and peripheral joints inflammation. Non-radiographic axial spondyloarthropathy or nr-axSPA is a common early sign of AS before developing radiographic sacroiliitis. Visfatin is an adipokine produced in fat tissue mainly, as well as in skeletal muscle, brain, and hepatocytes. Visfatin has been demonstrated to contribute to bone homeostasis and it can induce pro-inflammatory responses in different cell types.Objective: This study aimed to investigate serum visfatin level among AS, nr-axSPA patients and controls and to elucidate its possible relationship with disease activity. Patients and methods: This was a case-control study, which comprised 26 AS cases, 26 nr-axSPA cases and 27 healthy volunteers age-and sex-matched with the patient groups. ELISA was used in measuring visfatin concentration in the serum of studied subjects. Results: Serum visfatin level was significantly higher in AS and nr-axSPA cases groups in comparison with control group (p<0.001). There was positive correlation between visfatin with Bath AS Disease Activity Index (BASDI) (P= 0.032) and (P=0.001), and Bath AS Functional Index (BASFI) (p=0.004) and (p=0.001) in AS and nr-axSPA groups respectively. There were significant positive correlations between modified Stoke AS Spinal Score (mSASSS) and visfatin values in AS group (p<0.001). Visfatin concentrations didn't correlate with age, BMI, disease duration, ESR, CRP and ASDAS-CRP. Conclusion: Serum visfatin concentration was elevated in cases with AS and nr-axSPA, and it was accompanied by disease activity, functional impairment and radiographic damage.

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Section: Figure (1): Visfatin Levels Among Studied Groupssupporting

confidence: 93%

Section: Figure (1): Visfatin Levels Among Studied Groupssupporting

confidence: 92%

Serum Visfatin levels in Ankylosing Spondylitis: Correlation with Disease Activity

2024

The Egyptian Journal of Hospital Medicine

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“…In addition, visfatin increases the expression of vascular endothelial growth factor (VEGF) by activating the PI3K/Akt, ERK1/2, p38 MAPK, and JNK1/2 signaling pathways, which induces endothelial angiogenesis [ 71 ]. It has been shown that an increase in the level of visfatin is associated with an increase in cIMT, so it can be considered a marker of subclinical atherosclerosis [ 72 ].…”

Section: Pro-inflammatory Adipokines In Obesity and Its Complicationsmentioning

confidence: 99%

The Role of Adipokines in Inflammatory Mechanisms of Obesity

Kirichenko

Markina

Bogatyreva

et al. 2022

IJMS

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Adipokines are currently widely studied cellular signaling proteins produced by adipose tissue and involved in various processes, including inflammation; energy and appetite modulation; lipid and glucose metabolism; insulin sensitivity; endothelial cell functioning; angiogenesis; the regulation of blood pressure; and hemostasis. The current review attempted to highlight the key functions of adipokines in the inflammatory mechanisms of obesity, its complications, and its associated diseases. An extensive search for materials on the role of adipokines in the pathogenesis of obesity was conducted online using the PubMed and Scopus databases until October 2022.

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“…Although spine involvement is more frequent, joint, extra-articular regions, and entheses are also affected. In individuals with AS, an increase in disability level and a decrease in quality of life are observed [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Validation and cross-cultural adaptation of the Turkish version of the revised Leeds Disability Questionnaire in patients with ankylosing spondylitis

Özkeskin¹,

Özden²,

Aktan³

et al. 2022

Turkish Journal of Medical Sciences

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Background/aim The revised Leeds Disability Questionnaire (RLDQ) is a unique assessment tool for patients with ankylosing spondylitis (AS); its comprehensive structure includes posture and neck flexibility parameters. The aim of the study was to determine the psychometric properties of the Turkish RLDQ in patients with AS. Materials and methods A total of 100 AS patients were enrolled in the study. In the first evaluation, patients filled out the Dougados Functional Index (DFI) and Bath Ankylosing Spondylitis Functional Index (BASFI), Stanford Health Assessment Questionnaire (HAQ) in addition to RLDQ. Then, patients were refilled the revised RLDQ in the second assessment. Results The mean age of the patients (40 women, 60 men) was 48.3 ± 12.6 years. The test-retest reliability and internal consistency of the RLDQ total score were excellent. ICC score and Cronbach’s alpha score were calculated as 0.853 and 0.905, respectively. The SEM and MDC values calculated for the RLDQ total score were 2.74 and 7.60, respectively. RLDQ had degrees of correlation with DFI, HAQ, and BASFI of 0.814, 0.742, and 0.852, respectively. Construct validity was excellent (r > 0.50, p < 0.01). Conclusion The Turkish version of the RLDQ was found to be valid and reliable in patients with AS. It should be emphasized that the RLDQ is a distinctive and valuable tool that focuses separately on neck, posture, or other mobility parameters in the clinical assessment of AS.

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The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis

Cited by 6 publications

References 37 publications

Serum Visfatin levels in Ankylosing Spondylitis: Correlation with Disease Activity

Serum Visfatin levels in Ankylosing Spondylitis: Correlation with Disease Activity

The Role of Adipokines in Inflammatory Mechanisms of Obesity

Validation and cross-cultural adaptation of the Turkish version of the revised Leeds Disability Questionnaire in patients with ankylosing spondylitis

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