The relationship of serum uric acid with non-alcoholic fatty liver disease

Sertoğlu, Erdim; Erçin, Cemal Nuri; Çelebi, Gürkan; Gürel, Hasan; Kayadibi, Hüseyin; Genç, Halil; Kara, Muammer; Doğru, Teoman

doi:10.1016/j.clinbiochem.2014.01.029

Cited by 67 publications

(56 citation statements)

References 34 publications

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“…22 There are also several studies suggesting that SUA level is significantly associated with NAFLD. 12,13 However, few data are available about the relationship between SUA level and inflammation associated with NAFLD in non-obese adults. In 93 cases of non-obese biopsy-proven NAFLD we found that there were no significant differences between non-NASH and NASH groups, except for ALT and SUA levels.…”

Section: Discussionmentioning

confidence: 99%

“…Although numerous studies have reported that SUA level is associated with NAFLD, 12,13 no study has aimed to investigate the association of SUA level with NAFLD and its inflammation progression in non-obese adults. This study aimed to investigate the clinical and histopathologic characteristics of NAFLD, and then analyze the relationships between SUA, NAFLD, and degree of inflammation in non-obese adults.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of serum uric acid level with non‐alcoholic fatty liver disease and its inflammation progression in non‐obese adults

Liu

Ying

et al. 2016

Hepatology Research

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Aim: This study aimed to evaluate the relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) in non-obese adults.Methods: A cross-sectional study was carried out among 4098 adults, including 1936 non-obese and 2162 obese individuals. An additional 93 non-obese adults with biopsy-proven NAFLD were also included.Results: The overall prevalence of NAFLD was 39.51% in the study group, and 14.88% in non-obese adults. The NAFLD patients had significantly higher SUA levels than controls in both men and women. The non-obese group had a higher NAFLD risk with increased SUA levels than the obese group, with odd ratios (95% confidence interval) of 2.559 (1.870-3.503) and 1.692 (1.371-2.087), respectively. In 93 non-obese adults with biopsyproven NAFLD, SUA levels were significantly higher in those with non-alcoholic steatohepatitis. The prevalence of non-alcoholic steatohepatitis and lobule inflammation tended to increase to 57.58% and 66.67% as the SUA level increased to the fourth quartile. Subjects with hyperuricemia had significantly higher NAFLD activity scores and more serious lobule inflammation than the normal group.Conclusion: Non-obese adults have higher NAFLD risk with increased SUA levels than obese individuals, and the inflammation progression of NAFLD is associated with increased SUA level in non-obese subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship of serum uric acid level with non‐alcoholic fatty liver disease and its inflammation progression in non‐obese adults

Liu

Ying

et al. 2016

Hepatology Research

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“…Previous studies have shown close correlations between T2DM and NAFLD, and T2DM has been considered as one of the most common risk factor for NAFLD [2]. Recently, serum uric acid (SUA) has received increasing attention in the NAFLD field, which is now considered as an independent risk factor in NAFLD [3][4][5]. However, little is known about SUA in NAFLD in the Chinese population.…”

Section: Introductionmentioning

confidence: 98%

The Risk Factor Analysis for Type 2 Diabetes Mellitus Patients with Nonalcoholic Fatty Liver Disease and Positive Correlation with Serum Uric Acid

Xie

Musha

et al. 2015

Cell Biochem Biophys

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Recent years, we has witnessed a sharp increase in the complications of Type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Here we aimed to determine the risk factors for T2DM patients with NAFLD and the relationship of serum uric acid (SUA) in these complications. We performed retrospective analysis of 300 T2DM patients admitted into our hospital from April 2010 to January 2014. We divided the T2DM patients into two groups based on whether the patients also had NAFLD or not, Group A (without NAFLD, 155 cases) and Group B (with NAFLD, 145 cases). General information of the patients was collected and analyzed statistically. Meanwhile, we detected and compared the blood biochemistry, glucose, and fasting insulin (FINS), and further performed Logistic regression analysis and determined the risk factors in T2DM patients with NAFLD. Significantly higher BMI, waist circumference, hip circumference, WHR, systolic, and diastolic blood pressure were observed in T2DM patients with NAFLD than the patients without NAFLD, which were statistically different (P < 0.05). There were also significant higher levels of TC, TG, ALT, AST, GGT, and SUA in T2DM patients with NAFLD than those in patients without NAFLD, which were statistically different (P < 0.05). Significantly higher levels of FPG, FINS, and HOMA-IR were observed in the T2DM patients with NAFLD than those without, which were statistically significant (P < 0.05). Logistic regression analysis also showed high BMI, WHR, TG, and SUA were independent risk factors in T2DM patients with NAFLD (P < 0.05). Meanwhile, SUA levels were positively correlated with BMI, W, H, WHR, hip circumference, waist circumference, TG, ALT, AST, GGT, FPG, FINS, and HOMA-IR, which were statistically significant (P < 0.05). The risk factors for T2DM patients with NAFLD are mainly BMI, WHR, TG, and SUA. Our findings provide clinical implications for the prevention and early diagnosis of T2DM patients with NAFLD.

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“…The significant association between uric acid and non-alcoholic fatty liver disease suggest that high uric acid levels may play an important role in the development of NALFD. Previous studies have shown that the increase serum uric acid levels were independently and positively associated with the risk for incident non-alcoholic fatty liver disease with obesity and with diabetes [41,42,43]. The injured liver cells released uric acid and induced inflammation [44,45] In the normal condition the liver can be exported and transformed of large crystals of uric acid.…”

Section: Discussionmentioning

confidence: 99%

Study of serum ferritin, serum uric acid and plasma malondialdehyde (MDA) levels in non-alcoholic fatty liver disease

Varma¹,

Makwane²,

Kare³

et al. 2016

Int J of Biomed & Adv Res

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Background: Non-alcoholic fatty liver disease (NAFLD) is one of most important cause of fatty liver that may lead to endstage liver disease. Various studies have reported that serum ferritin, serum uric acid and plasma malondialdehyde (MDA) levels are related to the development of NAFLD. Diabetes and obesity are the major risk factors which are associated with NAFLD. The aim of this study was estimation of serum ferritin, serum uric acid and plasma MDA levels in NAFLD patients with diabetes and with obesity. Materials and Methods:In the present study, total (n = 230) subjects were recruited for the study and divided in three groups. Group I; (n = 79) diagnosed cases of non-alcoholic fatty liver disease with diabetes, group II; (n = 71) diagnosed cases of nonalcoholic fatty liver disease with obesity patients and group III included (n = 80) healthy control subjects. Serum ferritin was measured by ELISA method. Estimation of serum uric acid was done by uricase peroxidase colorimetric method. Plasma MDA was estimated by spectrophotometric method. Results: The present study shown that serum ferritin, serum uric acid and plasma MDA levels were significantly increased (p<0.001) in NAFLD with diabetes mellitus patients (333.42±82.93, 14.29±1.87, 7.75±3.35, respectively) as compared with healthy controls (126.30±72.12, 5.19±1.72, 2.79±0.52, respectively), and also significantly increased (p < 0.001) in NAFLD with obesity patients (300.87±85.80, 12.08±2.81, 7.43±3.05, respectively) when they compared with healthy controls (126.30±72.12, 5.19±1.72, 2.79±0.52, respectively). Conclusion: Serum ferritin, serum uric acid and plasma MDA are associated with the increased risk for non-alcoholic fatty liver disease.

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The relationship of serum uric acid with non-alcoholic fatty liver disease

Cited by 67 publications

References 34 publications

Relationship of serum uric acid level with non‐alcoholic fatty liver disease and its inflammation progression in non‐obese adults

Relationship of serum uric acid level with non‐alcoholic fatty liver disease and its inflammation progression in non‐obese adults

The Risk Factor Analysis for Type 2 Diabetes Mellitus Patients with Nonalcoholic Fatty Liver Disease and Positive Correlation with Serum Uric Acid

Study of serum ferritin, serum uric acid and plasma malondialdehyde (MDA) levels in non-alcoholic fatty liver disease

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