The relationship of serum alkaline phosphatase concentrations to sex maturity ratings in adolescents

Bennett, David; Ward, Michael S.; Daniel, William A.

doi:10.1016/s0022-3476(76)80025-x

Cited by 35 publications

(11 citation statements)

References 11 publications

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“…The findings of increased mean plasma concentrations of alkaline phosphatase at different ages and stages of sexual maturation of peak growth velocity are in agreement with earlier reports (23,24,49,50) and, conceivably, reflect increased osteoblastic bone formation (3).…”

Section: Discussionsupporting

confidence: 92%

Plasma Concentrations of Vitamin D Metabolites in Puberty: Effect of Sexual Maturation and Implications for Growth*

Aksnes

Aarskog

1982

The Journal of Clinical Endocrinology & Metabolism

130

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To relate the vitamin D metabolism in puberty to sex, sexual maturation, and, indirectly, to growth velocity and cessation of growth, the plasma level of 25-hydroxy vitamin D, 1,25-dihydroxyvitamin D [1,25-(OH)2D], 24,25-dihydroxyvitamin D [24,25-(OH)2D], and 25,26-(OH)2D were measured in 191 adolescents representing all stages of puberty. In girls, 1,25-(OH)2D3 increased from age 11 yr to a peak at 12 yr of age (P less than 0.0005) and then decreased. In boys, the increase occurred between 13--14 yr of age (P less than 0.005), with a subsequent decline. When the 1,25-(OH)2D concentrations were related to the stage of puberty, the girls showed a maximal increase between stages 1 and 2 (P less than 0.0005), with a peak at stage 3, whereas the boys had a significant increase from stage 2 to a peak at stage 3 (P less than 0.01). In both sexes, there were subsequent significantly decreasing values to stage 4 through stage 5. The ratio of 24,25-(OH)2D to 25-hydroxyvitamin D varied inversely with the 1,25-(OH)2D concentration, with the lowest value at age 12 yr in both sexes, followed by a gradual increase to a plateau at age 15 yr in girls and 17 yr in boys. It appears that the hormones of the vitamin D system add another dimension to the endocrinology of growth and puberty.

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Section: Discussionsupporting

confidence: 92%

Plasma Concentrations of Vitamin D Metabolites in Puberty: Effect of Sexual Maturation and Implications for Growth*

Aksnes

Aarskog

1982

The Journal of Clinical Endocrinology & Metabolism

130

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“…A correlation between osteocalcin levels and alkaline phosphatase activities has also been reported in childhood (33). It is now well established that there is a link between alkaline phosphatase activity and sexual maturity (34,35,36,37,38), which was also confirmed by our results.…”

Section: Discussionsupporting

confidence: 91%

Osteocalcin. A biochemical marker of bone turnover during puberty

Kanbur¹,

Derman²,

Şen³

et al. 2002

International Journal of Adolescent Medicine and Health

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During bone remodelling, osteocalcin is produced by osteoblasts and its level increases during the events characterized by rapid bone turnover. Osteocalcin is a bone matrix protein, which is specific for bone metabolism and it is not influenced by metabolic bone disorders. Osteocalcin is an important marker of bone turnover in physiological and pathological conditions. Physiologically, serum osteocalcin was increased in children, particularly during the first year of life and during puberty, when evolution of the concentration was related to rapidity of physical growth. Evidence of a correlation with growth rates comes from the observation that serum osteocalcin levels parallel the height velocity curve, with higher values in childhood and during adolescence, that later fall to adult values. There are previous studies reporting that there is age-and sex-dependent change in serum osteocalcin levels in children and adolescents with a pattern resembling height velocity curves for children and serum osteocalcin elevation coincides with the pubertal growth spurt. These findings demonstrate that pubertal development and sex should be taken into account rather than chronological age when serum levels of osteocalcin are evaluated. In most of the studies relationships among osteocalcin and chronological age and bone age, but not pubertal developmental stage (sexual maturation stage) were investigated. The aim of our study was to determine whether osteocalcin is a useful marker for the pubertal growth spurt period. In this study, osteocalcin levels in male adolescents were examined in relation to their sexual maturation stage and age. According to our findings, the follow up of osteocalcin levels in relation to sexual maturation stages could be a new method to determine the phase of the pubertal growth spurt. An increase or decrease in osteocalcin levels on consecutive measurements may indicate the child's entering accelerated or decelerated stages of the growth spurt, respectively. We emphasize that the follow up of adolescent growth is made by determination of the sexual maturation stage, and not by age. Osteocalcin is a highly specific, reliable and useful marker for evaluation of the growth spurt and is not influenced by nonosseous disorders.

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“…This effect will be most marked at low excretion values, but will not alter the overall picture of a rise and fall in total hydroxyproline excretion during the adolescent growth spurt. The alkaline phosphatase results are similar to those reported by de Wijn (1966) and Bennett et al (1976).…”

Section: Discussionsupporting

confidence: 91%

“…Most of the studies in this field are cross-sectional and examine a single biochemical variable wkh respect to age (Stearns and Warweg 1933, Muley and H urwitz 1938, Hare 1950, Clarke and Beck 1950, Greenberg et al 1960, Dunnigan and Garden 1965, Zorab 1969, Zorab et al 1970, Arnaud et al 1973, Salz et al 1973, Round 1973. Observations on the progress of sexual maturation together with biochemical data are rare (De Wijn 1966, Bennett et al 1976). Since the milestones of sexual maturation and the occurrence of the adolescent growth spurt are to some extent related, in that increasing testosterone levels in boys and adrenal androgens in girls during puberty are important in increasing the rate of bone and muscle growth (Tanner 1975), this study analyses some biochemical changes during sexual development in boys and girls.…”

Section: Introductionmentioning

confidence: 99%

Changes in plasma urate, creatinine, alkaline phosphatase and the 24 hour excretion of hydroxyproline during sexual maturation in adolescents

Jm¹

1980

Annals of Human Biology

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The relative concentrations of plasma uric acid and creatinine, the alkaline phosphatase activities and the 24 hour urinary excretion of hydroxyproline together with sexual maturity ratings are reported in a population of normal British schoolchildren studied longitudinally over a three-year period. The children were all of European origin and their ages ranged from 7 to 17 years. Plasma urate rose sharply during puberty in the boys but not in the girls. Plasma creatinine rose in both sexes during maturation. Plasma alkaline phosphatase activity rose to a peak at genital maturity 3(G3) in boys and breast maturity 2(B2) in girls and subsequently fell rapidly in both sexes. The 24-hour urinary secretion of hydroxyproline was high in young boys and rose to a peak during G3 and G4 and then fell rapidly. In girls there was no significant peak in concentrations, although there was a fall during B4 and B5, and levels were higher throughout puberty than those reported for adult females.

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The relationship of serum alkaline phosphatase concentrations to sex maturity ratings in adolescents

Cited by 35 publications

References 11 publications

Plasma Concentrations of Vitamin D Metabolites in Puberty: Effect of Sexual Maturation and Implications for Growth*

Plasma Concentrations of Vitamin D Metabolites in Puberty: Effect of Sexual Maturation and Implications for Growth*

Osteocalcin. A biochemical marker of bone turnover during puberty

Changes in plasma urate, creatinine, alkaline phosphatase and the 24 hour excretion of hydroxyproline during sexual maturation in adolescents

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