The relationship of seizure focus with depression, anxiety, and health-related quality of life in children and adolescents with epilepsy

Executive Dysfunction and Depression in Pediatric Temporal Lobe Epilepsy: The Contribution of Hippocampal Sclerosis and Psychosocial Factors

“…Parent rated depression features on the BASC-2 fell in the At-risk range as a group (M = 60.55; SD = 14.38), and 21 children (33.9%) were rated as having Clinically Significant features of depression. These rates are consistent with previous research (Salpekar et al, 2013;Schraegle & Titus, 2017a;Titus et al, 2008).…”

Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy

“…Epilepsy is a chronic brain disorder characterized by recurrent seizures caused by abnormal neuronal activity; it has an incidence of 5-10 per 1000 people [1,2]. Patients with epilepsy display a wide range of devastating medical, social, and economic disadvantages, which result in a significant burden to both patients and family [3,4]. Although substantial progress has been made in the development of anti-epileptic drugs and understanding their underlying mechanisms, new anti-epilepsy approaches are still required.…”

Assessment and Management of Depression and Anxiety in Children and Adolescents with Epilepsy

“…There was no difference between temporal and frontal lobe epilepsy groups for measures of anxiety or withdrawal. Within the subset of children with partial epilepsy, there were no differences in affective symptoms based on seizure laterality, and, in the cohort as a whole, there was no difference in affective symptoms between those children with partial epilepsy and those with generalised epilepsy [8]. Another cohort of children with diagnoses of complex partial seizures and childhood absence epilepsy ( n = 171, age range: 5 to 16) reported that children with complex partial seizures—essentially the same patient population as those with temporal lobe epilepsy—have a higher rate of depression and comorbid depression and anxiety disorders and a lower rate of anxiety disorders ( p < 0.02), when compared to childhood absence epilepsy, a common generalised epilepsy of childhood.…”

“…The cornerstone of management is vigilant recognition and active monitoring for psychiatric morbidity in children and adolescents with epilepsy. This is particularly critical in patients at a possible higher risk for such morbidity, such as those with temporal lobe epilepsy [8, 9] and those receiving polytherapy [17]. As previously noted, the diagnosis of psychiatric morbidity in those patients with intellectual disability presents a particular difficulty.…”