The Relationship of Seborrheic Keratosis and Basal‐Cell Carcinoma?

White, Stephen W.; Bescanceney, Charles F.

doi:10.1111/j.1524-4725.1983.tb00886.x

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…Some researchers have expressed doubt that malignant tumors can develop from seborrheic keratosis; they consider these transformations to be a pseudoepitheliomatous hyperplasia, irritated seborrheic keratosis, or an infringement of an adjacent malignant tumor (1). On the other hand, several researchers have presented compelling evidence that basal cell carcinoma can arise in seborrheic keratosis (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Besides basal cell carcinoma, isolated cases of squamous cell carcinoma (16), Bowen's disease and carcinoma in situ of epidermis (17)(18)(19), keratoacanthoma (20), and malignant melanoma (21) have all been reported to arise in seborrheic keratosis.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis

Akasaka

Kon

1997

The Journal of Dermatology

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The present study reports two cases of basal cell carcinoma arising in seborrheic keratosis. The first case is a seventy-three-year-old female who presented with a blackish nodule arising from a pigmented lesion on her chest. Histopathological analysis of the nodule and the pigmented lesion revealed a basal cell carcinoma with hair follicular differentiation and an acanthotic seborrheic keratosis, respectively. The second case is a seventy-year-old female with a blackish nodule arising from a pigmented lesion on her back. Histological analysis of the nodule revealed an atypical basaloid cell mass surrounded by a seborrheic keratosis lesion. In addition to the coexisting seborrheic keratosis with the basal cell carcinoma, a basaloid follicular hamartoma that showed multiple hamartomatous hair follicles or small cysts replaced by a branching cord or lace-like network of basaloid cells surrounded by fibrovascular stroma was identified. We concluded that both cases presented a rare combination of a seborrheic keratosis which underwent a malignant change to basal cell carcinoma. It appears that both basal cell carcinomas and seborrheic keratosis may derive from a similar source: pluripotential cells of either the epidermis or hair follicle epithelium.

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Section: Discussionmentioning

confidence: 99%

Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis

Akasaka

Kon

1997

The Journal of Dermatology

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“…Some researchers have expressed doubt about malignant transformation of seborrheic keratosis, and suggested that coexistences of seborrheic keratosis and malignant tumors were only a coincidence, an infringement of a malignant tumor onto seborrheic keratosis, a pseudoepitheliomatous hyperplasia, or irritated seborrheic keratosis (9). On the other hand, several researchers have insisted that malignant tumors that can arise in seborrheic keratosis include basal cell carcinoma (3)(4)(5), squamous cell carcinoma (8), Bowen's disease and in situ carcinoma (6,7,10), keratoacanthoma (11), and malignant melanoma (12). However, the development of a secondary malignant tumor is very rare.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor is thought to derive from normal epidermis (1) or hair follicule epithelium (2), and is not considered to present any risk of malignancy. However, a few cases with epidermal malignant transformation such as basal cell carcinoma (3)(4)(5), Bowen's disease (6,7) and squamous cell carcinoma (8) have been reported. To the best of our knowledge, transformation from seborrheic keratosis into a sweat duct tumor has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A Possible Case of Eccrine Poroma Arising in Seborrheic Keratosis with Partial Intermediate Malignancy and Tumor of the Follicular Infundibulum

Akasaka

Kon

1997

The Journal of Dermatology

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An eighty-year-old woman presented with a eccrine poroma that appeared to have arisen in a seborrheic keratosis lesion on the right side of her abdomen. The tumor consisted of a brownish, flat, elevated lesion with an eroded nodule at its periphery. Histopathological analysis of the flat, elevated lesion revealed benign basaloid and squamoid cells that showed acanthotic upward proliferation, suggesting a seborrheic keratosis. The eroded nodule showed irregular proliferation of slight atypical squamoid cells with, in parts, ductal structures in the upper dermis, suggesting that it was an eccrine poroma with partial intermediate malignancy. In addition to the eroded nodule, an occult tumor clinically accompanied the seborrheic keratosis. Histopathology of the occult tumor revealed fenestrated columns and cords of pale epithelial cells attached to the base of the seborrheic keratosis lesion, which was diagnosed as a tumor of the follicular infundibulum. Although reports of seborrheic keratosis transforming into a sweat gland tumor are rare, the present case suggests that seborrheic keratosis may develop into benign or malignant adnexal tumors, including sweat gland and follicular tumors. Thus, seborrheic keratosis should be considered as a possible precursor of adnexal tumor.

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“…While some authors deny this possibility altogether, 1, 2 others suggest that pseudoepithelioma‐tous hyperplasia, 3 irritated seborrheic keratosis, premalignant fibroepithelioma of Pinkus, 1 or infringement of an adjacent malignant tumor onto seborrheic keratosis 1, 3 may have been misinterpreted as tumors arising within seborrheic keratoses. Nevertheless, several authors present indubitable evidence of BCC arising in seborrheic keratoses 4–13 . Aside from BCC, other tumors, e.g., squamous cell carcinoma, 14, 15 keratoacanthoma, 16 malignant melanoma, 17 and Bowen's 18–20 disease have been observed to arise in seborrheic keratoses.…”

Section: Commentmentioning

confidence: 99%