The relationship of Prohepcidin levels with anemia and inflammatory markers in non-diabetic uremic patients: a controlled study

Aydın, Zeki; Gürsu, Meltem; Karadağ, Serhat; Uzun, Sami; Şumnu, Abdullah; Döventaş, Yasemin Erdoğan; Öztürk, Savaş; Kazancıoğlu, Rümeyza

doi:10.3109/0886022x.2014.937663

Cited by 10 publications

(12 citation statements)

References 13 publications

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“…We found that hepcidin was significantly correlated with creatinine, but with negative insignificant correlation with albumin. This is in agreement with Aydin et al [46] . However the correlation between hepcidin and albumin is significantly negative.The difference in albumin is due to the small size of our study.…”

Section: Discussionsupporting

confidence: 94%

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Elmenyawi¹,

Hassan²,

Said³

2017

Egyptian Journal of Hospital Medicine

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Objective: Uremia is a state of heightened inflammatory activation. This might have an impact on several parameters including those used in the management of anemia as ferritin, serum iron, transferrin saturation, C-reactive protein (CRP) and hepcidin levels. In spite of this complexity the existing data indicate that hepcidin has an advantage over ferritin in guiding treatment of anemia in patients with chronic kidney disease (CKD) as it directly reflects iron availability and the status of iron homeostasis. Aim of the study: was to determine serum hepcidin levels in maintenance haemodialysis (HD) patients and to investigate its relation to ferritin and markers of inflammation as C-reactive protein. Subjects and methods: This study was conducted on 40 maintenance haemodialysis patients and 20 agematched apparently healthy controls from October 2015 till February 2016 at the Haemodialysis Departement, National Institute of Urology and Nephrology (NIUN). Creatinine, albumin, hemoglobin, leucocytic count, CRP, hepcidin and ferritin were measured. Results: Serum ferritin and hepcidin levels were significantly higher in HD patients compared with controls (825.67 ± 956.52 ng/ml and 9.2 ± 4.2 ng/ml vs 85.1± 63.35 ng/ml and 0.75 ± 0.39 ng/ml respectively) (p< 0.001).There was significant difference in CRP in HD patients compared with controls (4.28 ± 3.7mg/L vs 1.35±1.04mg/L respectively)(p<0.05).There were insignificant positive weak correlations between serum levels of hepcidin and ferritin (r = 0.05, P = 0.74). Conclusion: Serum hepcidin levels are increased in HD patients and, hence, could be used in the evaluation of anemia in such patients. Serum hepcidin provides useful information about the level and availability of iron during inflammation as compared with traditional markers of iron status. Availability of the ELISA assay for serum hepcidin will facilitate the routine measurement of hepcidin in clinical practice.

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Section: Discussionsupporting

confidence: 94%

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Elmenyawi¹,

Hassan²,

Said³

2017

Egyptian Journal of Hospital Medicine

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“…Malyszko et al found a positive correlation between hepcidin and CRP levels, whereas others did not. [17][18][19][20][21] In the study by Caliskan et al, 20 serum prohepcidin levels were found to be significantly associated with serum IL-6 levels, however, no significant association was found between prohepcidin and CRP in HD patients. In addition, in our study, serum hepcidin levels were not related to serum CRP levels.…”

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confidence: 94%

C-reactive protein but not hepcidin, NGAL and transferrin determines the ESA resistance in hemodialysis patients

et al. 2015

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“…[12] , also a study on patients with combined heart, renal failure and anemia, hepcidin levels was increased in comparison to healthy reference populations. [18], [19], [20] In this study hepcidin was negatively correlated to serum hemoglobin, serum iron and total iron binding capacity (P<0.01). (Table 3), figure (3 increased interleukin-6, high sensitive CRP may contribute to this condition.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Role of Hepcidin in Predicting the Therapeutic Efficacy of Erythropoiesis-Stimulating Agent Treatment in Patients of Chronic Renal Failure

El-HadyAhmed

El-Maghraby

2016

Zagazig University Medical Journal

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Background: Chronic kidney disease is associated with increase serum hepcidin level which contributes to severity of anemia and to resistance of erythropoiesis stimulating agents and dysregulation of iron hemostasis. Serum hepcidin correlates positively with ferritin in patients on hemodialysis. Subjects and Methods: fifty patients of end stage renal disease(ESRD) on regular hemodialysis and on erythropoietin therapy, twenty seven males, twenty three females and twenty subjects as control. Group matched for age, gender were clinically assessed and laboratory investigations were done in the form of serum urea, creatinine, iron profile (serum iron, ferritin, total iron binding capacity), serum erythropoietin, serum hepcidin, and hemoglobin. Results: There is significant negative correlation between hepcidin and hemoglobin, iron, total iron binding capacity and erythropoietin (P<0.01) and positive significant correlation between serum hepcidin and serum ferritin (P<0.05) in both male and female groups. Hepcidin and serum ferritin are higher in patients groups than control but erythropoietin is lower in patients groups than control with statistical significance (P<0.01).

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The relationship of Prohepcidin levels with anemia and inflammatory markers in non-diabetic uremic patients: a controlled study

Cited by 10 publications

References 13 publications

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

C-reactive protein but not hepcidin, NGAL and transferrin determines the ESA resistance in hemodialysis patients

Evaluation of the Role of Hepcidin in Predicting the Therapeutic Efficacy of Erythropoiesis-Stimulating Agent Treatment in Patients of Chronic Renal Failure

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