The relationship of parathyroid activity to pyrophosphate excretion.

Avioli, Louis V.; McDonald, Joseph E.; Henneman, Philip H.; Lee, S W

doi:10.1172/jci105415

Cited by 24 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The finding of normal urinary PP, levels in hyperparathyroidism similarly concurs with previous studies by Russell and Hodgkinson (40) and Lewis et a1 (48), but contrasts with the elevated levels reported by Avioli et a1 (38,39). The reason for this discordance is uncertain, but may relate to differences in assay technique, correction of values to creatinine, or the severity of associated bone or joint disease (40).…”

Section: Discussionsupporting

confidence: 88%

Inorganic Pyrophosphate in Metabolic Diseases Predisposing to Calcium Pyrophosphate Dihydrate Crystal Deposition

Doherty

Chuck

Hosking

et al. 1991

Arthritis & Rheumatism

View full text Add to dashboard Cite

Inorganic pyrophosphate (PP,) levels were estimated by radiometric assay in urine and in synovial fluid (SF) froim asymptomatic, nonarthritic knees of patients with iuntreated metabolic disease and normal controls. SF F'P, was significantly elevated in patients with hyperparathyroidism (mean f SEM 19 k 3 pM; n = 9), hemochromatosis (23 f 5 pM; n = 6), and hypomagnesemia (27 f 0.1 pM; n = 2) compared with normal subjec1.s (10 f 0.5 pM, n = 50), and was low in patients with hypothyroidism (4.2 f 2.3 pM; n = 11) (P < 0.05 all comparisons). Urinary PP, was elevated only in those with hypophosphatasia. Local elevation of ionic PP, may be relevant to the mechanism of crystal formation in metabolic diseases predisposing to calcium pyrophosphate dihydrate (CPPD) crystal deposition. The finding of low SF PP, levels in patients with hypothyroidism further questions the association between this condition and CPPD.Factors recognized as predisposing to chondrocalcinosis due to calcium pyrophosphate dihydrate (CPPD) crystal deposition include aging (M), the osteoarthritis process (2-7), a familial predisposition (1,7-12), and associated metabolic disease (I ,7,13). In

show abstract

Section: Discussionsupporting

confidence: 88%

Inorganic Pyrophosphate in Metabolic Diseases Predisposing to Calcium Pyrophosphate Dihydrate Crystal Deposition

Doherty

Chuck

Hosking

et al. 1991

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…4 These effects of PTE on hydroxyproline excretion probably cannot be explained by any changes in renal clearance produced by the hormone. Peptides containing hydroxyproline are rapidly cleared by the kidneys under normal conditions (27), and it has recently been demonstrated (28) that injection of PTE into the renal artery of dogs does not increase the excretion of hydroxyproline peptides until after the PTE has increased the resorption of bone.…”

Section: Discussionmentioning

confidence: 99%

Collagen Degradation and the Response to Parathyroid Extract in the Intact Rhesus Monkey*

Avioli¹,

Prockop²

1967

J. Clin. Invest.

View full text Add to dashboard Cite

Summary. Proline-14C was administered to five adult rhesus monkeys, and the degradation of collagen was followed by the excretion of hydroxyproline-14C. The results suggested the presence of at least three separate pools of collagen with half-lives of 1 to 2, 2 to 3, and 50 to 70 days. The monkeys were killed after 44 days; at that time the specific activity of the hydroxyproline-14C in urine was found to be four to five times that of the hydroxyproline in soluble collagen and 81 to 93% that of hydroxyproline in insoluble collagen. The relationships between urinary hydroxyproline and the degradation of collagen were similar to those previously demonstrated in rats.Parathyroid hormone was administered daily to two of the monkeys from the 27th to the 44th day of the study. The parathyroid hormone increased the amount of hydroxyproline-'4C excreted, but there was no significant change in the specific activity of the urinary hydroxyproline-14C. Since under the conditions of the experiment insoluble collagen was the only possible source of hydroxyproline-14C of relatively high specific activity, the results indicated that parathyroid hormone directly or indirectly increased the degradation of insoluble collagen. The results also suggested that parathyroid hormone increased the degradation of soluble collagen, but the relative magnitude of this effect was not clearly established. Introduction Hydroxyproline accounts for approximately

show abstract

“…Studies on the disappearance of small amounts of ["'PIPPI injected intravenously in dogs have shown that plasma PPI is subject to a high rate of metabolic turnover and confirm that urinary excretion constitutes only a minor route for the disappearance of PPI fromplasma (Jung et al, 1970). In view of this high turnover, it is unlikely that the small amounts of PPI that could be derived from resorption of bone could comprise a major portion of the PPI excreted daily in urine, as was at one time thought (Avioli, McDonald & Singer, 1965;Avioli, McDonald, Henneman & Lee, 1966). The major part of the PPI in body fluids is more likely to arise as a by-product of the many biosynthetic reactions that produce PPI during pyrophosphorylysis of nucleotide triphosphates (Kornberg, 1962).…”

Section: Discussionmentioning

confidence: 73%

The Influence of Orthophosphate on the Renal Handling of Inorganic Pyrophosphate in Man and Dog

1976

View full text Add to dashboard Cite

1. The urinary excretion of inorganic pyrophosphate (PPi), a known inhibitor of the growth and aggregation of crystals of calcium phosphate and calcium oxalate, increases after ingestion of orthophosphate (Pi). This effect may contribute to the apparent ability of oral phosphate to reduce the formation of urinary stones in man. This paper is a study of the mechanism by which Pi increases PPi excretion, investigated by renal clearance techniques in man and renal arterial infusion in dogs. PPi in plasma was measured by an isotope-dilution method after ion-exchange chromatography. 2. The mean renal clearance of endogenous PPi in ten men was 7-9 +/- 1-7 (SE) ml/min, and the mean ratio of PPi clearance to creatinine clearance was 0-08 +/- 0-02 (SE). The oral ingestion of Pi increased the urinary excretion and renal clearance of PPi about threefold, without significantly changing its concentration in plasma. 3. In dogs, the infusion of Pi into one renal artery caused a greater increase in urinary PPi from the infused than from the non-infused kidney, an effect that could be accentuated by simultaneous intravenous infusion of PPi. In dogs, only 1-3% of an injected or infused dose of PPi appeared intact in the urine, regardless of whether it was infused into the systemic or renal circulation. 4. These results suggest that Pi has a direct affect on the kidney to increase the excretion of PPi. It is possible that Pi either interferes with tubular reabsorption of PPi, perhaps by competing for a common tubular transport mechanism, or that Pi diminishes the intrarenal hydrolysis of PPi.

show abstract

The relationship of parathyroid activity to pyrophosphate excretion.

Cited by 24 publications

References 22 publications

Inorganic Pyrophosphate in Metabolic Diseases Predisposing to Calcium Pyrophosphate Dihydrate Crystal Deposition

Inorganic Pyrophosphate in Metabolic Diseases Predisposing to Calcium Pyrophosphate Dihydrate Crystal Deposition

Collagen Degradation and the Response to Parathyroid Extract in the Intact Rhesus Monkey*

The Influence of Orthophosphate on the Renal Handling of Inorganic Pyrophosphate in Man and Dog

Contact Info

Product

Resources

About