The relationship of oxygen consumption to cerebral functional activity

Garfunkel, Joseph M.; Baird, Henry W.; Ziegler, Joseph

doi:10.1016/s0022-3476(54)80093-x

Cited by 53 publications

(10 citation statements)

References 27 publications

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“…In patients with chronic degenerative cerebral diseases, such a relationship was first noted by Freyhan, Woodford and Kety in their study of aged psychotic patients (2). This finding has since been confirmed by many investigators studying related clinical problems (3)(4)(5)(6)(7). In general, a reduction of CMRO2 was found to be associated with a proportionate reduction of the cerebral blood flow (CBF).…”

mentioning

confidence: 75%

Bilateral Studies of Cerebral Oxygen Uptake in Young and Aged Normal Subjects and in Patients With Organic Dementia

Lassen¹,

Feinberg²,

Lane³

1960

J. Clin. Invest.

161

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mentioning

confidence: 75%

Bilateral Studies of Cerebral Oxygen Uptake in Young and Aged Normal Subjects and in Patients With Organic Dementia

Lassen¹,

Feinberg²,

Lane³

1960

J. Clin. Invest.

161

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“…In vitro measurements of the rate of oxygen consumption and glucose utilization in the brain as a whole have shown that the cerebral metabolic rate is low at birth and increases with maturity (Fazekas et al, 194 1;Himwich and Fazekas, 194 1;Garfunkel et al, 1954;Duffy et al, 1975;Gregoire et al, 1978;Hernandez et al, 1978). Applications of the 2-%-deoxyglucose autoradiographic method to newborn animals have demonstrated that LCMRglu are also heterogeneous throughout the brain of immature animals, but the values are lower and distributed over a smaller range than those obtained in the mature rat or monkey brain (Gregoire et al, 198 1;Duffy et al, 1982;Kennedy et al, 1982;Abrams et al, 1984).…”

Section: Inserm U272 54013 Nancy Cedex Francementioning

confidence: 99%

Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development

1988

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The quantitative 2–14C-deoxyglucose autoradiographic method of Sokoloff et al. (1977) was used to measure local cerebral glucose utilization in freely moving developing rats. The animals were studied at 10, 14, 17, 21, and 35 d and at the adult stage. Glucose utilization was very low and quite uniform in 10- and 14-d-old rats, ranging from 20 to 30 mumol/100 gm/min, except in a few posterior areas. Between these 2 stages, rates of glucose utilization significantly increased in 6 areas, among which 4 were belonging to the auditory system. Between 14 and 17 d, glucose utilization significantly changed in 9 structures out of the 68 studied, mainly auditory, visual, parietal, and thalamic areas. Between the stages of 17 and 21 d, glucose utilization was increased by 50 or 100% in all brain structures studied, except in the medial habenula and white matter areas. After weaning time, rates of glucose utilization still significantly changed in 50 areas, widely distributed through all studied systems. Between 35 d and the adult stage, the average rate of glucose utilization did not change and rates of energy metabolism significantly increased in 13 brain areas. In one structure, the medial habenula, glucose utilization was already high 10 d after birth and did not change over the whole studied period. These increases in the rates of glucose utilization are consistent with the behavioral, anatomical, and functional changes known to occur during this period of development in the rat.

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“…Close correlations were documented between cerebral O 2 consumptions and mental function, including depression and dementia [17,18]. It is unknown if our finding of slower lymphocyte respiration in trisomy 21 children is applicable to other organs.…”

Section: Discussionmentioning

confidence: 84%