The relationship of oral health with general health and NCDs: a brief review

Abstract

Oral health is closely related to systemic health. Periodontitis, a chronic inflammatory disease which is highly prevalent worldwide, interacts with a variety of noncommunicable diseases (NCDs). It is a risk factor in the complex pathogenesis of diabetes mellitus and cardiovascular disease and plays a role in the development of endocarditis and recurrent pneumonia in elderly people. However, the available data may be interpreted in different ways, and more and better-designed studies are still needed to answer relevant questions about the causal role of periodontitis in NCDs. What is clear is that periodontitis contributes to the systemic inflammatory burden. As periodontitis shares many common risk factors with NCDs, close collaboration between physicians and dentists is needed to increase the chance of early detection and improve the prevention and control of these conditions.

Impaired glucose metabolism is associated with tooth loss in middle-aged adults: The Northern Finland Birth Cohort Study 1966

“…Tooth loss can substantially impair one's quality of life, causing limited chewing ability, poor dietary intake and functional disorders [1]. Research has shown diabetes and cardiovascular diseases to associate with oral health and tooth loss [2][3][4][5], and elevated glucose levels with common periodontal disease [6][7][8]. Similar finding has been reported between glucose concentration and the number of teeth [8].…”

Individualisierte Prävention – Implikation allgemeingesundheitlicher Faktoren

“…Das Zusammenwirken zwischen Allgemeinerkrankungen und der (dentalen als auch parodontalen) Mundgesundheit, insbesondere bezüglich der parodontalen Entzündungslast gilt heutzutage als nachgewiesen, wenngleich kausale Beziehungen schwierig zu beweisen sind [21,22]. Bidirektionale Beziehungen zwischen Mund-und Allgemeingesundheit sind dabei ebenso möglich wie eine…”

miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis

“…2 If not treated, periodontitis is a risk factor for prominent noncommunicable diseases, including pneumonia, gastritis, diabetes mellitus, and chronic renal disorders; also, the number of lost teeth is predictive of mortality by cardiovascular conditions. 3 As a multifactorial disease, genetic and inhibiting their translation. Approximately 50% of the microRNA genes are associated with CpG islands, and their expression may be regulated by DNA methylation pathways.…”