The relationship of olfactory function and clinical traits in major depressive disorder

Wang, Fang; Wu, Xiaohui; Gao, Jerry; Li, Yongchao; Zhu, Yuncheng; Fang, Yiru

doi:10.1016/j.bbr.2020.112594

Cited by 15 publications

(19 citation statements)

References 81 publications

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“…Several studies have shown that olfactory impairment can affect QoL and may lead to depression [12]. Following that line, the improvement in sense of smell may be expected to be a potential antidepressant therapy [13].…”

Section: Loss Of Smell Etiologymentioning

confidence: 99%

Olfactory Dysfunction in the COVID-19 Outbreak

Izquierdo-Domínguez¹,

Rojas-Lechuga²,

Mullol³

et al. 2020

J Investig Allergol Clin Immunol

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The first cases of coronavirus 2019 (COVID-19) occurred in Wuhan, China, and rapidly become a public health emergency of international proportions. The disease may cause mild-to-severe acute respiratory syndrome (SARS) and is caused by a SARS-CoV-2 coronavirus infection. The clinical manifestations of COVID-19 include fever, dry cough, fatigue, sputum production, shortness of breath, sore throat, and headache. This article is a narrative review with the aim of analyzing the current literature on postviral olfactory dysfunction (OD) related to SARS-CoV-2 pandemics. Since the initial anecdotal reports from China, international reports on COVID-19 patients have been increasing, describing a 5% to 85% range of loss of smell. To date, the literature is widely heterogeneous regarding the loss of smell; therefore, we advise home isolation measures and/or social distancing, and to carry out diagnostic tests for SARS-CoV-2 when possible in those patients with sudden and severe loss of smell who cannot be promptly evaluated.neurons nor the olfactory bulb neurons express specific genes that are instead expressed in support cells, stem cells, and perivascular cells. These findings suggest that infection of non-neuronal cell types leads to anosmia and related disturbances in odour perception in patients [7,8]

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Section: Loss Of Smell Etiologymentioning

confidence: 99%

Olfactory Dysfunction in the COVID-19 Outbreak

Izquierdo-Domínguez¹,

Rojas-Lechuga²,

Mullol³

et al. 2020

J Investig Allergol Clin Immunol

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“…This was of great significance for early detection of potential cognitive decline and dementia in T2DM patients. Moreover, olfactory function was also found to be related to the pathogenesis of MDD ( 87 ). Olfactory sulcus structural abnormality might be a trait-related marker of vulnerability to MDD ( 88 ).…”

Section: Discussionmentioning

confidence: 99%

Altered White Matter Microstructures in Type 2 Diabetes Mellitus: A Coordinate‐Based Meta‐Analysis of Diffusion Tensor Imaging Studies

Zhou

Li²,

Dong

et al. 2021

Front. Endocrinol.

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ObjectiveType 2 diabetes mellitus (T2DM) is often accompanied by cognitive decline and depressive symptoms. Numerous diffusion tensor imaging (DTI) studies revealed microstructural white matter (WM) abnormalities in T2DM but the findings were inconsistent. The present study aimed to conduct a coordinate‐based meta‐analysis (CBMA) to identify statistical consensus of DTI studies in T2DM.MethodsWe performed a systematic search on relevant studies that reported fractional anisotropy (FA) differences between T2DM patients and healthy controls (HC). The anisotropic effect size seed‐based d mapping (AES-SDM) approach was used to explore WM alterations in T2DM. A meta‐regression was then used to analyze potential influences of sample characteristics on regional FA changes.ResultsA total of eight studies that comprised 245 patients and 200 HC, along with 52 coordinates were extracted. The meta‐analysis identified FA reductions in three clusters including the left inferior network, the corpus callosum (CC), and the left olfactory cortex. Besides, FA in the CC was negatively correlated with body mass index (BMI) in the patients group.ConclusionsT2DM could lead to subtle WM microstructural alterations, which might be associated with cognitive deficits or emotional distress symptoms. This provides a better understanding of the pathophysiology of neurodegeneration and complications in T2DM.Systematic Review RegistrationRegistered at PROSPERO (http://www.crd.york.ac.uk/PROSPERO), registration number: CRD42020218737.

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“…Many studies have shown that olfactory impairment is associated with depression in human adults ( Atanasova et al, 2008 ; Croy et al, 2014 ; Kohli et al, 2016 ; Croy and Hummel, 2017 ; Taalman et al, 2017 ; Rochet et al, 2018 ; Rottstaedt et al, 2018 ; Wegener et al, 2018 ; Pabel et al, 2020 ; Qazi et al, 2020 ; Wang et al, 2020 ; Athanassi et al, 2021 ; Kim and Bae, 2022 ; Liu et al, 2022 ; Sabiniewicz et al, 2022 ). Moreover, olfactory dysfunction precedes and predicts the development of depression in older adults ( Eliyan et al, 2021 ).…”

Section: Olfaction Is Associated With Depressionmentioning

confidence: 99%

Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression

Leon

Woo

2022

Front. Neurosci.

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The loss of olfactory stimulation correlates well with at least 68 widely differing neurological disorders, including depression, and we raise the possibility that this relationship may be causal. That is, it seems possible that olfactory loss makes the brain vulnerable to expressing the symptoms of these neurological disorders, while daily olfactory enrichment may decrease the risk of expressing these symptoms. This situation resembles the cognitive reserve that is thought to protect people with Alzheimer’s neuropathology from expressing the functional deficit in memory through the cumulative effect of intellectual stimulation. These relationships also resemble the functional response of animal models of human neurological disorders to environmental enrichment, wherein the animals continue to have the induced neuropathology, but do not express the symptoms as they do in a standard environment with restricted sensorimotor stimulation.

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The relationship of olfactory function and clinical traits in major depressive disorder

Cited by 15 publications

References 81 publications

Olfactory Dysfunction in the COVID-19 Outbreak

Olfactory Dysfunction in the COVID-19 Outbreak

Altered White Matter Microstructures in Type 2 Diabetes Mellitus: A Coordinate‐Based Meta‐Analysis of Diffusion Tensor Imaging Studies

Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression

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