The relationship of morphometric changes of the brain with IL-6 levels, systemic inflammation and immune disturbances in the patients with schizophrenia

Malashenkova, I K; Ushakov, Vadim L.; Krynskiy, Sergey; Ogurtsov, Daniil; Khailov, N. A.; Zakharova, Natalia; Chekulaeva, Ekaterina; Orlov, Vyacheslav A.; Kartashov, Sergey; Andreyuk, D. S.; Didkovsky, Nikolay; Kostyuk, Georgiy

doi:10.1016/j.procs.2021.06.064

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…Отметим, что по данным наших предыдущих исследований [18,19], структурные изменения при МРТ, часть из которых по результатам данной работы ассоциирована с повышенным уровнем IL-17A, также связаны с наличием у больных выраженной негативной симптоматики. Это указывает на роль IL-17A не только в качестве показателя выраженной активации провоспалительных механизмов и дисрегуляции адаптивного иммунитета у больных шизофренией, но и как потенциального биомаркера клинически значи-Малашенкова И.К.…”

Section: Discussionunclassified

“…Описанные нарушения могут по-разному сочетаться у больных ШЗ, создавая многочисленные иммунные паттерны, и предполагают, что они могут нарушать сигнальные и метаболические пути на периферии и в головном мозге [23]. Ряд исследований указывают на связь характера и выраженности иммунологических расстройств с прогнозом шизофрении и характером симптоматики заболевания [9,18,27].…”

Section: Introductionunclassified

“…Ранее нами сообщалось об ассоциации уровня цитокинов врожденного иммунитета с изменениями показателей структурной МРТ при шизофрении. Очевидно, что в патогенезе шизофрении важную роль играет как врожденный, так и адаптивный иммунитет [17,18].…”

Section: Introductionunclassified

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Association of IL-17A levels with immuneinflammatory profile and structural MRI data in patients with schizophrenia

et al. 2022

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IL-17A is a proinflammatory cytokine involved in pathogenesis of some neuroinflammatory diseases of the brain. However, its role in schizophrenia is poorly understood. Currently, noninvasive neuroimaging techniques are widely used to assess abnormalities in brain morphology and interactions of neuronal networks in schizophrenia. The aim of this work was to study associations between IL-17A level and brain morphometric parameters in schizophrenia, in order to clarify immune factors of pathogenesis and search for biomarkers of unfavorable disease course. 45 patients with schizophrenia and 30 healthy volunteers were included into the study. The levels of cytokines (IL-5, IL-6, IL-8, IL-10, IL-17A) and inflammatory markers were determined by ELISA or multiplex analysis. MRI scans were performed with a Siemens Magnetom Verio 3T MRI scanner. We used Kruskal–Wallis test to assess significant differences in immunological parameters followed by Mann–Whitney paired comparison; Student test to assess the significance of differences in morphometric parameters of the brain; Fisher exact test to assess the differences in discrete variables, with the differences considered statistically significant at p < 0.05. IL-17A levels were found to be increased in schizophrenia. Its elevated content was associated with increased levels of C-reactive protein, IL-5, IL-6, IL-8, IL-10, and the presence of morphometric changes of frontal and temporal cortex in the patients. So far, the relationships between IL-17A levels, immunoinflammatory parameters and structural brain changes have not been studied in schizophrenia. In the present work, we found an association of elevated IL-17A levels with decreased cortical thickness in several brain regions, systemic inflammation and activation of Th2-link of adaptive immunity in the patients with schizophrenia. According to the literature, a number of brain areas, where cortical thickness was associated with IL-17A levels may be relevant to pathogenesis of the disease and, in particular, to the development of negative symptoms, including impoverishment of interests, speech, and emotions. The results are important for understanding the role of immune disorders in pathogenesis of schizophrenia, including structural changes of the brain, and suggest that IL-17A may be a biomarker of these disorders. Confirmation of associations between structural neuroimaging findings, laboratory markers of inflammation and immune disorders may provide the basis for new multidisciplinary approaches to the diagnosis and prognosis of schizophrenia.

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Section: Discussionunclassified

Section: Introductionunclassified

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Association of IL-17A levels with immuneinflammatory profile and structural MRI data in patients with schizophrenia

et al. 2022

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“…The level of IL-6 is closely related to inflammation, viral infection, and other autoimmune diseases. In the case of systemic infection, the increase of IL-6 will be more obvious ( Artaza-Irigaray et al, 2019 ; Malashenkova et al, 2021 ; Prairie et al, 2021 ). PGE2 is the primary inflammatory mediator of inflammatory diseases such as rheumatoid arthritis, osteoarthritis, hormone dermatitis, and allergic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of extracts from Acer truncatum leaves on SLS-induced HaCaT cells

Fan

Gu²,

Zhang³

et al. 2023

Front. Pharmacol.

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Introduction:A. truncatum Bunge (Sapindaceae or formerly Aceraceae) is a tall deciduous tree native to China. Traditionally, the leaves of A. truncatum are decocted and used by Chinese Mongolians, Koreans, and Tibetans to treat skin itching, dry cracks, and other skin ailments, which indicates A. truncatum leaves may have a potential inhibitory effect on various skin inflammations.Methods: To examine the protective effect against skin inflammations of A. truncatum leaf extract (ATLE), an in vitro dermatitis model was established using sodium dodecyl sulfate (SLS)-induced HaCaT cells. The anti-inflammatory effect of ATLE was evaluated by analyzing cell viability, apoptosis, reactive oxygen species (ROS), interleukin 6 (IL-6), and prostaglandin E2 (PGE2) levels.Results: Orthogonal experiments showed that the pretreatment with ATLE can reduce the IL-6 levels, PGE2 levels, and apoptosis increased in SLS-stimulated HaCaT cells, which indicates that ATLE has positive efficacy for dermatitis. Furthermore, three flavonoid compounds kaempferol-3-O-α-L-rhamnoside, quercetin-3-O-α-L-rhamnopyranoside, kaempferol-3,7-di-O-α-L-rhamnoside, and 1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose (PGG) were isolated and identified. Among them, kaempferol-3,7-di-O-α-L-rhamnoside was isolated from this plant for the first time. These compounds have been proven to have an anti-inflammatory effect. They may contribute to the efficacy of A. truncatumin treating skin inflammation.Discussion: The results revealed that ATLE has the potential to be used as an additive in various skin care products to prevent skin inflammations and may be incorporated in formulations for topical application as a therapeutic approach against dermatitis.

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“…Сравнительная частота психопатологических симптомов и синдромов при COVID-19-ассоциированных психозах (% от абс. числа пациентов) психопатологических проявлений следствием нейровоспаления [38][39][40][41][42]. Признается также действие механизма «бредовых вспышек» (bouffée délirante) в условиях тяжелой сенсорной депривации, изоляции и жестких ограничительных мер [43].…”

Section: Introductionunclassified

COVID-19-Associated Schizophrenia-Like Psychosis

Bravve¹,

Zakharova²

2023

Psychiatry

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Background: COVID-19-associated psychoses are psychotic disorders that have developed during a new coronavirus infection. Criteria of these psychoses are the manifestation of psychosis simultaneously with infection with the SARS-CoV-2 virus and the presence of documented COVID-19 disease. Information about these diseases appears as brief reports of mental services or with rare clusters. The need to study COVID-19-associated psychoses is due to the relatively high risk of their development, reaching 2.8%. The aim of study was to analyse the identified cases of COVID-19-associated psychosis in comparison with the results presented in the scientific literature. Patients and methods: 50 cases of COVID-19-associated psychosis were analyzed using a clinical method, taking into account the results of physical examination from April 2020 to September 2021. Results: 27 women and 23 men aged 20 to 57 were examined. Common symptoms were revealed: simultaneously or immediately after infection and identification of the virus against the background of growing anxiety and dissomnia, delusional ideas were formed, which quickly turned into fantastic delusion with disturbing agitation and hallucinations and subsequent marked disorganization of behavior with possible confusion of consciousness at the peak of psychosis. Perceptual deceptions were the most common, auditory hallucinations were the most prevalent, and catatonia was relatively common. The cupping therapy led to reduction of psychotic symptoms, and returned patients to a pre-morbid level of functioning. In most cases, there was a critical resolution of the attack, which probably indicates a favorable outcome of the disorder. Such dynamics is consistent with scientific literature data. Conclusion: the question of the primary or secondary nature of COVID-19-associated psychoses remains unresolved. It is necessary to continue the study of COVID-19-associated psychosis with the identification of risk factors for the development of psychosis, manifestation features, psychopathological picture, outcome options to determine the optimal rehabilitation program.

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The relationship of morphometric changes of the brain with IL-6 levels, systemic inflammation and immune disturbances in the patients with schizophrenia

Cited by 5 publications

References 21 publications

Association of IL-17A levels with immuneinflammatory profile and structural MRI data in patients with schizophrenia

Association of IL-17A levels with immuneinflammatory profile and structural MRI data in patients with schizophrenia

Protective effects of extracts from Acer truncatum leaves on SLS-induced HaCaT cells

COVID-19-Associated Schizophrenia-Like Psychosis

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