The relationship of medical, demographic and psychosocial factors to direct and indirect health utility instruments in rheumatoid arthritis

Abstract

Demographic and psychosocial factors cannot completely explain either the significant differences between direct and indirect HUs in RA patients or the moderate correlations of direct HUs with health status. Characteristics of the SG and TTO may make them inappropriate for HU assessment and CEA among RA patients.

The time to trade-off method versus the EQ-5D index to determine health utility in patients with rheumatoid arthritis

“…Описанные прямые методи-ки не обладают достаточной надеж-ностью при использовании у боль-ных РА [9]. Доля больных РА, неаде-кватно воспринимающих представ-ленные альтернативы для выбора, достигает 50% [10].…”

Russian registry of patients receiving rituximab: results of pharmacoeconomic analysis

“…Сущностью метода "стандартного риска" явля-ется предоставление больному информации о воз- [4]. Для больных РА основной целью терапии явля-ется улучшение КЖ, которое можно оценить специ-фическим опросником HAQ и/или общими -SF-36 и EQ-5D.…”

Valuation of quality of life in rheumatoid arthritis

“…The SG also demonstrated reliability (77,134). The results regarding construct validity of the TTO and SG were generally poor, with both instruments showing poor to moderate correlations with disease-or healthrelated outcome measures (78)(79)(80)132,(134)(135)(136)(137)(138)(139). Poor results were also found regarding their responsiveness (77,(138)(139)(140)(141)(142).…”

“…Nevertheless, it has been argued that the term 'utility' can be used in a broader sense as an index of the strength of preference both under conditions of certainty or uncertainty (76). In literature, the term has been frequently used to indicate preferences obtained by SG as well as TTO (77)(78)(79)(80), thus irrespective of whether there was risk or probabilities involved in the measurement questions. In subsequent paragraphs of this introduction and in the other chapters of this thesis, this broader meaning of the term 'utility' will be used to indicate valuations of health states.…”

“…TTO, specifically in RA, it can be observed that only a few studies have examined the psychometric properties of the TTO. The few studies that examined construct validity showed poor correlations of the TTO with measures of HRQoL, functional status, disease activity and pain (78)(79)(80). Evidence for and against its discriminative ability was found (78)(79)(80).…”