The Relationship of Macular Thickness to Clinically Graded Diabetic Retinopathy Severity in Eyes without Clinically Detected Diabetic Macular Edema

Browning, David J.; Fraser, Christina M.; Clark, Stephen

doi:10.1016/j.ophtha.2007.06.042

Cited by 80 publications

(68 citation statements)

References 25 publications

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“…As the severity of the retinopathy rises, the retinal thickness in creases as well. Browning et al emphasize that a single initial individualized study for future longitudinal comparisons is important, as the individual variation is wide, with a large standard deviation in the normal population (21) . This work has found that the greater the severity of retinopathy, greater is the CST, and the greater the thickness, the greater is macular volume.…”

Section: Discussionmentioning

confidence: 99%

“…assessment and the OCT can detect the progression of DME, once the slit lamp evaluation alone can result in errors (21) . However, there is no way to predict in which patients the DR will progress.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest applying OCT in either eye with DR that will undergo panretinal photocoagulation, once the OCT result may influence the use of adjuvant therapy (21) . Virgilli et al suggest that, in cases of clinical uncertainty about the existence of central EMD, the macular photocoagulation should not be indicated if central retinal thickness is below 250 μm, while values above 300 μm or more are strongly indicative of the need to treatment.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between central subfield thickness, visual acuity and structural changes in diabetic macular edema

Hannouche¹,

Ávila²,

Isaac³

et al. 2012

Arq. Bras. Oftalmol.

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Purpose: To correlate the central subfield thickness (CST) measured by Cirrus TM SD-OCT with best-corrected visual acuity (BCVA) and structural changes in diabetic macular edema (DME). Methods: The transversal study evaluated 200 patients with non-proliferative dia betic retinopathy (NPDR) and selected 55 eyes with DME between January, 2010 and April, 2011. Spectral domain OCT was performed in patients with type 2 diabetes and DME. CST and BCVA were correlated with the edema morphology and the ELM (external limiting membrane) integrity. Statistical tests were applied to validate the results. Results: There was no difference between genders in the NPDR classification. 47.3% of the patients showed moderate NPDR. The CST average for male was of 393.58 µm and 434.16 µm for female, with no statistically significant difference. The patients with continuous ELM showed lower CST average (368.73 µm) than those with disrupted ELM (521.43 µm). There was a strong correlation between the macular volume and CST (59.63%), but poor correlation between age and CST (2.9%). Also, there was a significant difference between the average CST and the type of macular edema. Patients with serous detachment showed higher CST average (488.71 µm) than those with cystoid macular edema (CME) and diffuse edema. Patients with severe NPDR showed higher CST average (491.45 µm), if compared to mild and moderate NPDR. Cystoid macular edema was the most common type of edema (49.1%) and showed the worse VA. Patients with disrupted ELM showed worse BCVA. Patients with higher CST showed worse BCVA. There was a significant difference between the CST average of the case group (407.6 ± 113,1 µm) and the control group (diabetic patients without DME: 252 ± 12.5 µm). There was also a significant difference in the BCVA variables and macular volume between case and control groups. Conclusion: The study suggests that the CST of diabetic patients with edema is higher than the control group, the increase in CST of diabetic patients with edema leads to worsening of BCVA and macular volume. Continuous ELM showed lower CST average, and the serous detachment showed higher CST average. Cirrus TM proved to be an important tool in the DME evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Correlation between central subfield thickness, visual acuity and structural changes in diabetic macular edema

Hannouche¹,

Ávila²,

Isaac³

et al. 2012

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

show abstract

“…According to the criteria from Early Treatment Diabetic Retinopathy Study, non-proliferative diabetic retinopathy was classified in mild, moderate and severe (2) . The control group was formed with 30 individuals, without diabetes mellitus, from 30 to 65 years of age, best-corrected visual acuity 20/40 or better, and refractometry between -3.00 and +3.00 dioptries.…”

Section: Methodsmentioning

confidence: 99%

“…A CFT of 200 µm was considered as normal, as in most referenced studies (2)(3) . All variables in this study presented statistic normal distribution, from Kolmogorov-Smirnov test (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Retinal thickness measurement and evaluation of natural history of the diabetic macular edema through optical coherence tomography

Hannouche¹,

Ávila

2009

Arq. Bras. Oftalmol.

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Disorganization of Inner Retina and Outer Retinal Morphology in Diabetic Macular Edema

et al. 2018

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IMPORTANCE In diabetic macular edema (DME), identification of baseline markers on spectral-domain optical coherence tomography (SD-OCT) and their association with severity of diabetic retinopathy (DR) might aid in disease management and the design of future trials. OBJECTIVE To examine associations between DR severity, retinal morphology on SD-OCT, and visual acuity in participants with DME. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional observational case series was conducted at a single tertiary care referral center. Demographics, visual acuity, SD-OCT, and color fundus photographs of 80 individuals with DME (102 eyes) seen between December 28, 2013, and April 30, 2014, were analyzed between May 1 and July 31, 2016. MAIN OUTCOMES AND MEASURES Features captured on SD-OCT and thickness metrics. On SD-OCT we graded type and shape of DME, shape and presence of septae within the intraretinal cystoid abnormalities, presence of hyperreflective dots and foci, integrity of the external limiting membrane and ellipsoid zone, presence and extent of disorganization of the inner retinal layers (DRIL), and the status of the vitreomacular interface and epiretinal membrane. We measured retinal thickness at the fovea and at the site of maximum pathology, choroidal thickness at the fovea, and 1000 μm temporal and nasal to the fovea. Color photographs were graded to derive a DR severity stage. RESULTS The mean (SD) age was 63 (11) years, and 30 participants (37.5%) were women.

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The Relationship of Macular Thickness to Clinically Graded Diabetic Retinopathy Severity in Eyes without Clinically Detected Diabetic Macular Edema

Cited by 80 publications

References 25 publications

Correlation between central subfield thickness, visual acuity and structural changes in diabetic macular edema

Correlation between central subfield thickness, visual acuity and structural changes in diabetic macular edema

Retinal thickness measurement and evaluation of natural history of the diabetic macular edema through optical coherence tomography

Disorganization of Inner Retina and Outer Retinal Morphology in Diabetic Macular Edema

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