The Relationship of Iron Metabolism and Hepcidin in Childhood

Semercioglu, Elif Almila; Solgun, Huseyin Avni; Kılınç, Yurdanur

doi:10.5152/cjm.2020.20022

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In iron de ciency, hepcidin decreases and iron absorption increases, which leads to iron release from deposits (15). In a study conducted by Semercioglu et al, hepcidin levels were found to be signi cantly lower in children with iron de ciency anemia compared to the children without iron de ciency anemia (17). In parallel with the said study and the literature, in the present study, hepcidin level was found to be signi cantly lower in the iron de ciency group in comparison to the control group.…”

Section: Discussionsupporting

confidence: 85%

Erythroferrone and Hepcidin Levels in Children with Iron Deficiency Anemia

Dulkadir

Turna

Güneş

2023

Preprint

View full text Add to dashboard Cite

Purpose: In the study, it was aimed to determine the correlation between erythroferrone (ERFE) and hepcidin levels in patients with iron deficiency anemia and laboratory parametersused in diagnosing iron deficiency anemia, and to investigate whether the drugs that may lead to an increase in EFTE or will suppress hepcidin could be new treatmentmodalities in iron deficiency anemia. Method: 26 cases who presented to the pediatrics clinic with a diagnosis of iron deficiency anemia and did not have a concomitant disease and 26 healthy children were included in the study. In the study conducted with a case-control design, normal hemoglobin and hematocrit lower limits according to age and gender and red cell indices based on normal age and gender determined by the World Health Organization were used for the diagnosis of anemia. In order to evaluate iron status, serum iron, total iron binding capacity (TIBC), and ferritin levels were analyzed. Serum hepcidin and erythroferrone levels in children diagnosed with iron deficiency before the start of the iron treatment and at the end of first month of their treatment and in the control group were measured with ELISA method. Findings: Compared to the control group, hemoglobin (p < 0,001), MCV (p = 0,001), MCH (p < 0,001), MCHC (p < 0,001), iron (p < 0,001), ferritin (p < 0.001) and hepcidin (p = 0.001) levels in Group I were found to be significantly lower. Besides, RDW value was significantly higher in the iron deficiency group compared to the control group (p=0.001). When Group I and Group II values were compared, significant increases were determined in erythrocyte count (p=0.034), hemoglobin, hematocrit, MCV (p<0.001 for each), MCHC (p=0.002), iron (p<0.001), ferritin (p=0.015) and hepcidin levels (p<0.001). A significant decrease was found in iron binding capacity after the treatment (p=0.004). In Group I, hepcidin levels had a significant and strong correlation with initial ferritin levels (r = 0.829, p < 0.001). When erythrocyte levels of Group I and Group II were compared, there was a decrease in the erythrocyte levels of Group II, but this decrease was not statistically significant. However, hepcidin levels displayed moderate or weak correlation with neutrophil count (r = -0.429, p = 0.037), eosinophil count (r = -0.447, p = 0.029) and iron level (r = 0.594, p = 0.002). Conclusion: In the study, a strong and positive correlation was determined between ferritin and hepcidin levels in individuals with iron deficiency. This may suggest that hepcidin is largely regulated by iron deposit level. In addition, following the iron treatment, an increase was found in ferritin and hepcidin levels. In the study, no significant difference was found between theiron deficiency group and the control group in terms of erythroferrone levels.

show abstract

Section: Discussionsupporting

confidence: 85%

Erythroferrone and Hepcidin Levels in Children with Iron Deficiency Anemia

Dulkadir

Turna

Güneş

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Dallalio et al (26) showed a positive correlation between hepcidin and ferritin in patients with anemia. In a study where 94 patients with IDA and 91 control groups were included, it was found that hepcidin level was lower in the patient group with IDA compared to the control group (27). The largest studies performed with hepcidin to date are two large studies including 2998 patients in the Netherlands and 1577 patients in Italy.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Treatment on Weight Gain in Iron Deficiency Anemia and Its Association with Ghrelin and Hepcidin Levels

KILINÇ,

ÖNEÇ,

ONEC

et al. 2023

Düzce Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Aim: Although loss of appetite in iron deficiency anemia (IDA) and weight gain during treatment are common complaints, there are very few studies in adults. This study aimed to determine the levels of ghrelin, one of the appetite-related hormones, and hepcidin, one of the main regulators of iron metabolism, in IDA, and to examine the effects of treatment on weight gain and the levels of these hormones. Material and Methods: Eighty-seven adult patients with IDA and a control group of 50 healthy volunteers were included in the study. Anthropometric measurements and blood samples were obtained from the patient and control groups before treatment, and repeated after treatment in the IDA group. Results: No significant difference was found in terms of weight, body mass index (BMI), and waist-to-hip ratio between groups but there was a significant increase in weight and BMI, in the patient group after treatment (both p

show abstract

Erythroferrone and hepcidin levels in children with iron deficiency anemia

Dulkadir,

Turna Saltoğlu,

Güneş

2024

BMC Pediatr

View full text Add to dashboard Cite

Background Iron deficiency anemia remains a significant public health issue in developing countries. The regulation of iron metabolism is primarily controlled by hepcidin, a key regulatory protein. During erythropoiesis, erythroferrone (ERFE), a hormone produced by erythroblasts in response to erythropoietin (EPO) synthesis, mediates the suppression of hepcidin. In this study, it was aimed to determine the correlation between erythroferrone (ERFE) and hepcidin levels in children with iron deficiency anemia. Methods This is a case-control study conducted at Kırşehir Ahi Evran University Training and Research Hospital Pediatrics Clinic between 1 and 31 September 2020. The study included 26 healthy children and 26 children with iron deficiency anemia. In order to evaluate iron status,whole blood count, serum iron, total iron binding capacity (TIBC), and ferritin levels were analyzed. The study measured the levels of hepcidin and erythroferrone in the serum of children diagnosed with iron deficiency before and after one month of iron treatment, as well as in a control group, using the ELISA method. Correlation between whole blood count, initial ferritin, hepcidin, ERFE and ferritin in the iron deficiency group was evaluated. Results Compared with healthy controls, the iron-deficient group had significantly lower haemoglobin (p < 0.001), MCV (p = 0.001), MCH (p < 0.001), MCHC (p < 0.001), iron (p < 0.001), ferritin (p < 0.001) and hepcidin (p = 0.001). Ferritin and hepcidin levels increased while erythroferrone levels remained unchanged after iron deficiency treatment. There was no correlation between hepcidin and ferritin levels in treatment group. Conclusions The study found a strong and positive correlation between ferritin and hepcidin levels in iron-deficient children, but not between ERFE levels, suggesting that hepcidin is largely regulated by iron deposition levels. In addition, there was an increase in ferritin and hepcidin levels after iron treatment. The study found no significant difference in erythroferrone levels between the iron-deficient group and the control group. It is thought that this may be due to the short duration of iron treatment given to the patients with iron deficiency anemia included in the study.

show abstract

The Relationship of Iron Metabolism and Hepcidin in Childhood

Cited by 3 publications

References 0 publications

Erythroferrone and Hepcidin Levels in Children with Iron Deficiency Anemia

Erythroferrone and Hepcidin Levels in Children with Iron Deficiency Anemia

The Effect of Treatment on Weight Gain in Iron Deficiency Anemia and Its Association with Ghrelin and Hepcidin Levels

Erythroferrone and hepcidin levels in children with iron deficiency anemia

Contact Info

Product

Resources

About