The Relationship of Flowability, Hygroscopicity and Compressibility Properties between Microcrystalline Cellulose, Sarcandrae Extract Powder, and the Mixture of the Two Materials

Abstract

Microcrystalline Cellulose and Sarcandrae extract powder were used to study the relationships of pharmaceutical properties of powders before and after mixing operation. The theoretical values of the physical quantities of the binary mixture were calculated based on the random mixing theory. The measured values of angle of repose, hygroscopicity of binary mixture were larger than that of theoretical calculations. The effective Kawakita a and b for the MCC had changed by mixing operation. The parameters of blend powder reduced compared with MCC except D-1. The results suggested that the mixing behavior was not a complete random or simple superposition operation for the rough and sticky particles. The mixing process would create novel particles and the physical quantities of novel particles would changes regularly.

Flowability Properties of Binary Powder Mixtures Containing Dates Powder (Pheonix Dactylifera) Mixed With Lactose Monohydrate and Microcrystalline Cellulose Based Excipients

“…Combination of DP-Lac gave the lowest moisture when compared to DP-PH and DP-CE. Both Avicel® PH 102 and Avicel® CE15 are microcrystalline cellulose base excipients, and they have good hygroscopicity [44,45]. This explains higher reading of moisture content in the binary mixtures.…”